Dr. Du’s research is focused on molecular analysis of abnormal hematopoiesis, primarily on the molecular pathogenesis of bone marrow failure and leukemia. Her laboratory takes a multi-disciplinary approach including the development of preclinical murine models, genetics, genomics, molecular immunology, and biochemistry. Her research has been published in over 30 peer-reviewed articles and has contributed to the understanding of the pathophysiology of cancer-prone diseases, including Fanconi anemia.
The laboratory is funded through grants from Leukemia Research Foundation, American Cancer Society, WVU School of Pharmacy, WVU Health Science Center and NIH/NIGMS WV CTSI. We have teamed up with Drs. Laura Gibson from WVU Cancer Institute, Williams Petros and Lori Hazlehurst from WVU Cancer Institute and WVU School of Pharmacy to study the underlying mechanisms of hematological disease development. Other collaborative projects with Dr. Werner Geldenhuys from WVU School of Pharmacy in screening small molecules for refractory acute lymphoblastic leukemia treatment and improving hematopoietic stem cell function are also ongoing. The core facility usage in our investigations include the use of WVU Animal Model & Imaging Facility (AMIF), Flow Cytometry & Single Cell Core Facility, Transgenic Animal Core Facility, Genomics Core Facility and WVU Shared Research Facilities.