Project 1: "Role of KAP1 and KRAB-ZNFs in breast cancer"
Eukaryotic genomes are, in general, in a default state of repression, where the vast majority of genes are turned off or silenced. This repression is accomplished largely through packaging DNA into tightly coiled DNA-protein fibers called chromatin by association with histones and other proteins.
Project 2: "Molecular mechanisms of Snail/ZEB-induced EMT"
"Cancer is a disease of gene expression". Through studies of breast cancer we are trying to understand general principles of gene regulation in normal versus cancer cells with particular emphasis on gene transcription and microRNAs.