Publications of Alexey Ivanov, PhD

KAP1 promotes proliferation and metastatic progression of breast cancer cells. Addison JB, Koontz C, Fugett JH, Creighton CJ, Chen D, Farrugia MK, Padon RR, Voronkova MA, McLaughlin SL, Livengood RH, Lin CC, Ruppert JM, Pugacheva EN, Ivanov AV. Cancer Res. 2015;75(2):344-355. PMC4297582.

NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer. Loskutov YV, Kozyulina PY, Kozyreva VK, Ice RJ, Jones BC, Roston TJ, Smolkin MB, Ivanov AV, Wysolmerski RB, Pugacheva EN. Oncogene. 2014; [Epub ahead of print]

NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis. McLaughlin SL, Ice RJ, Rajulapati A, Kozyulina PY, Livengood RH, Kozyreva VK, Loskutov YV, Culp M, Weed SA, Ivanov AV, Pugacheva EN. Mol Cancer Res. 2014;12(1):69-81 PMC3946989.

NEDD9 depletion destabilizes Aurora A kinase and heightens the efficacy of Aurora A inhibitors: implications for treatment of metastatic solid tumors. Ice RJ, McLaughlin SL, Livengood RH, Culp M, Eddy ER, Ivanov AV, Pugacheva EN. Cancer Res. 2013;73(10):3168-3180. PMC3667743.

The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells. Pacurari M, Addison JB, Bondalapati N, Wan YW, Luo D, Qian Y, Castranova V, Ivanov AV, Guo NL. Int J Oncol. 2013;43(2):548-560. PMC3775564.

Suppression of the epithelial-mesenchymal transition by Grainyhead-like-2. Cieply B, Riley P, Pifer PM, Widmeyer J, Addison JB, Ivanov AV, Denvir J, Frisch SM.
Cancer Res. 2012;72(9):2440-2453

The ATM substrate KAP1 controls DNA repair in heterochromatin: regulation by HP1 proteins and serine 473/824 phosphorylation. White D, Rafalska-Metcalf IU, Ivanov AV, Corsinotti A, Peng H, Lee SC, Trono D, Janicki SM, Rauscher FJ, III. Mol Cancer Res. 2012;10(3):401-414.

Functional Analysis of KAP1 Genomic Recruitment. Iyengar S, Ivanov AV, Jin VX, Rauscher FJ, III, Farnham PJ. Mol Cell Biol. 2011;31(9):1833-1847 PMC3133220.

A KLF4-miRNA-206 autoregulatory feedback loop can promote or inhibit protein translation depending upon cell context. Lin CC, Liu LZ, Addison JB, Wonderlin WF, Ivanov AV, Ruppert JM. Mol Cell Biol. 2011;31(12):2513-2527 PMC3133414.

Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery. Peng HZ, Ivanov AV, Oh HJ, Lau YF, Rauscher FJ, III. J Biol Chem. 2009;284(51):35670-35680. PMC2790998.

Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Sarma K, Margueron R, Ivanov AV, Pirrotta V, Reinberg D. Mol Cell Biol. 2008;28(8):2718-2731.

Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing. Zeng L, Yap KL, Ivanov AV, Wang X, Mujtaba S, Plotnikova OV, Rauscher FJ, Zhou MM. Nat Struct Mol Biol. 2008;15(6):626-633 PMC3331790.

Regulation of protein tyrosine phosphatase 1B by sumoylation.Dadke S, Cotteret S, Yip SC, Jaffer ZM, Haj F, Ivanov AV, Rauscher FJ, III, Shuai K, Ng T, Neel BG, Chernoff J. Nat Cell Biol. 2007;9(1):80-85.

PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing. Ivanov AV, Peng H, Yurchenko V, Yap KL, Negorev DG, Schultz DC, Psulkowski E, Fredericks WJ, White DE, Maul GG, Sadofsky MJ, Zhou MM, Rauscher FJ, III Mol Cell. 2007;28(5):823-837.

Methylation-acetylation interplay activates p53 in response to DNA damage. Ivanov GS, Ivanova T, Kurash J, Ivanov AV, Chuikov S, Gizatullin F, Herrera-Medina EM, Rauscher FJ, III, Reinberg D, Barlev NA. Mol Cell Biol. 2007;27(19):6756-6769 PMC2099237.

Differential role of Sp100 isoforms in interferon-mediated repression of herpes simplex virus type 1 immediate-early protein expression. Negorev DG, Vladimirova OV, Ivanov AV, Rauscher FJ, III, Maul GG. J Virol. 2006;80(16):8019-8029. PMC1563809.

KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions. White DE, Negorev DG, Peng H, Ivanov AV, Maul GG, Rauscher FJ, III. Cancer Res. 2006;66(24):11594-11599.

[Retroviral reporter systems for the assessment of activity of stress-induced signal transduction pathways controlled by p53, HIF-1 and HSF-1 transcription factors]. Razorenova OV, Agapova LS, Budanov AV, Ivanov AV, Strunina SM, Chumakov PM. Mol Biol (Mosk). 2005;39(2):286-293. PMC2774898.

Virus-based reporter systems for monitoring transcriptional activity of hypoxia-inducible factor 1. Razorenova OV, Ivanov AV, Budanov AV, Chumakov PM. Gene. 2005;350(1):89-98. PMC2773277.

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. Wang C, Ivanov AV, Chen L, Fredericks WJ, Seto E, Rauscher FJ, III, Chen J. EMBO J. 2005;24(18):3279-3290. PMC1224681.

Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil. Pugacheva EN, Ivanov AV, Kravchenko JE, Kopnin BP, Levine AJ, Chumakov PM. Oncogene. 2002;21(30):4595-4600.

High constitutive level of NF-kappaB is crucial for viability of adenocarcinoma cells. Smirnov AS, Ruzov AS, Budanov AV, Prokhortchouk AV, Ivanov AV, Prokhortchouk EB. Cell Death Differ. 2001;8(6):621-630.

[Mutation of p53 is necessary for stable transformation of REF52 cells by myc+ras oncogenes]. Ivanov AV, Kopnin BP, Kondratov RV, Ossovskaya VS, Kopnin BP, Chumakov PM. Mol Biol (Mosk). 2000;34(2):316-325.

Treatment by methyl methanesulfonate induces up-regulation of cytomegalovirus immediate/early promoter. Nabirochkina EN, Ivanov AV. Biotechniques. 2000;29(4):732-4, 736.

[Identification of genes activated by mutant forms of p53]. Pugacheva EN, Ivanov AV, Snegur IE, Kopnin BP, Chumakov PM. Mol Biol (Mosk). 2000;34(1):143-151.

P53-dependent effects of RAS oncogene on chromosome stability and cell cycle checkpoints. Agapova LS, Ivanov AV, Sablina AA, Kopnin BP, Sokova OI, Chumakov PM, Kopnin BP. Oncogene. 1999;18(20):3135-3142.

[Induction of hyperdiploidy and chromosome breaks in LIM1215 cells expressing the exogenous mutant p53]. Agapova LS, Turovets NA, Ivanov AV, Il'inskaia GV, Chumakov PM. Genetika. 1996;32(8):1080-1087.

Park J, Schlederer M, Schreiber M, Ice R, Merkel O, Bilban M, Hofbauer S, Kim S, Addison J, Zou J, Ji C, Bunting ST, Wang Z, Shoham M, Huang G, Bago-Horvath Z, Gibson LF, Rojanasakul Y, Remick S, Ivanov A, Pugacheva E, Bunting KD, Moriggl R, Kenner L, Tse W. AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis. Oncotarget. 2015 Aug 21;6(24):20697-710.