Project Leader Anna Kiseleva is studying interaction between ErbB2 (HER2) receptor and NEDD9 scaffolding protein. The overexpression of HER2 receptor is associated with breast tumors and poor clinical outcome. NEDD9 plays an important role in cell cycle progression, migration, adhesion and invasion. Due to its ability to assemble different important oncogenic kinases, such as Aurora-A, focal adhesion kinase and SRC, NEDD9 was also found as a promising target against cancer progression.
The mail goal of my study is to determine a role of NEDD9 in HER2 -dependent breast tumorigenesis and metastasis using transgenic mouse and patient-derived models.