Publications of Yehenew Agazie PhD.

SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal-like and triple-negative breast cancer.
Matalkah F, Martin E, Zhao H, Agazie YM.
Breast Cancer Res. 2016;18(1):2


Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer.
Farrugia MK, Sharma SB, Lin CC, McLaughlin SL, Vanderbilt DB, Ammer AG, Salkeni MA, Stoilov P, Agazie YM, Creighton CJ, Ruppert JM.
Cell Death Dis. 2015;6:e1699


Inhibition of SHP2 in basal-like and triple-negative breast cells induces basal-to-luminal transition, hormone dependency, and sensitivity to anti-hormone treatment.
Zhao H, Agazie YM.
BMC Cancer. 2015;15(1):1131


HER2 stabilizes EGFR and itself by altering autophosphorylation patterns in a manner that overcomes regulatory mechanisms and promotes proliferative and transformation signaling.
Hartman ZR, Zhao H, Agazie YM.
Oncogene. 2013;32(35):4169-4180.


The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migration.
Hartman ZR, Schaller MD, Agazie YM.
Mol Cancer Res. 2013;11(6):651-664.


The signaling and transformation potency of the overexpressed HER2 protein is dependent on the normally-expressed EGFR.
Zhou XD, Agazie YM.
Cell Signal. 2012;24(1):140-150.


Molecular mechanism for SHP2 in promoting HER2-induced signaling and transformation.
Zhou XD, Agazie YM.
J Biol Chem. 2009;284(18):12226-12234.


Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells.
Zhou XD, Agazie YM.
Cell Death Differ. 2008;15(6):988-996.

SHP2 is up-regulated in breast cancer cells and in infiltrating ductal carcinoma of the breast, implying its involvement in breast oncogenesis.
Zhou XD, Coad JE, Ducatman BS, Agazie YM.
Histopathology. 2008;53(4):389-402.

Modulation of alpha-catenin Tyr phosphorylation by SHP2 positively effects cell transformation induced by the constitutively active FGFR3.
Burks J, Agazie YM.
Oncogene. 2006;25(54):7166-7179.

Mutation of Thr466 in SHP2 abolishes its phosphatase activity, but provides a new substrate-trapping mutant.
Merritt R, Hayman MJ, Agazie YM.
Biochim Biophys Acta. 2006;1763(1):45-56.

Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling.
Agazie YM, Hayman MJ.
Mol Cell Biol. 2003;23(21):7875-7886.


The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3.
Agazie YM, Movilla N, Ischenko I, Hayman MJ.
Oncogene. 2003;22(44):6909-6918.

Development of an efficient "substrate-trapping" mutant of Src homology phosphotyrosine phosphatase 2 and identification of the epidermal growth factor receptor, Gab1, and three other proteins as target substrates.
Agazie YM, Hayman MJ.
J Biol Chem. 2003;278(16):13952-13958.

Concomitant activation of the PI3K-Akt and the Ras-ERK signaling pathways is essential for transformation by the V-SEA tyrosine kinase oncogene.
Agazie YM, Ischenko I, Hayman MJ.
Oncogene. 2002;21(5):697-707.

Molecular mechanisms of ATP and insulin synergistic stimulation of coronary artery smooth muscle growth.
Agazie YM, Bagot JC, Trickey E, Halenda SP, Wilden PA.
Am J Physiol Heart Circ Physiol. 2001;280(2):H795-H801.

RHO-associated protein kinase alpha potentiates insulin-induced MAP kinase activation in Xenopus oocytes.
Ohan N, Agazie YM, Cummings C, Booth R, Bayaa M, Liu XJ.
J Cell Sci. 1999;112 ( Pt 13):2177-2184.

A rho-associated protein kinase, ROKalpha, binds insulin receptor substrate-1 and modulates insulin signaling.
Farah S, Agazie YM, Ohan N, Ngsee JK, Liu XJ.
J Biol Chem. 1998;273(8):4740-4746.

ATP-stimulated smooth muscle cell proliferation requires independent ERK and PI3K signaling pathways.
Wilden PA, Agazie YM, Kaufman R, Halenda SP.
Am J Physiol. 1998;275(4 Pt 2):H1209-H1215.

Molecular cloning and characterization of Xenopus insulin-like growth factor-1 receptor: its role in mediating insulin-induced Xenopus oocyte maturation and expression during embryogenesis.
Zhu L, Ohan N, Agazie YM, Cummings C, Farah S, Liu XJ.
Endocrinology. 1998;139(3):949-954.