Publications of John B. Barnett, PhD.

Suppression of arthritis-induced bone erosion by a CRAC channel antagonist.
Blair HC, Soboloff J, Robinson LJ, Tourkova IL, Larrouture QC, Witt MR, Holaskova I, Schafer R, Elliott M, Hirsch R, Barnett JB.
RMD Open. 2016;2(1):e000093

PMC4716559.

Improving the risk assessment of lipophilic persistent environmental chemicals in breast milk.
Lehmann GM, Verner MA, Luukinen B, Henning C, Assimon SA, LaKind JS, McLanahan ED, Phillips LJ, Davis MH, Powers CM, Hines EP, Haddad S, Longnecker MP, Poulsen MT, Farrer DG, Marchitti SA, Tan YM, Swartout JC, Sagiv SK, Welsh C, Campbell JL, Jr., Foster WG, Yang RS, Fenton SE, Tornero-Velez R, Francis BM, Barnett JB, El-Masri HA, Simmons JE.
Crit Rev Toxicol. 2014;44(7):600-617.

PMC4115797.

The toxicity of the N-hydroxy and 6-hydroxy metabolites of 3,4-dichloropropionanilide does not depend on calcium release-activated calcium channel inhibition.
Lewis TL, Holaskova I, Barnett JB.
Toxicol Sci. 2013;131(2):395-405.

PMC3551424.

Additive effects of exogenous IL-12 supplementation and antibiotic treatment in infection prophylaxis.
Boyce BM, Lindsey BA, Clovis NB, Smith ES, Hobbs GR, Hubbard DF, Emery SE, Barnett JB, Li BY.
J Orthop Res. 2012;30(2):196-202.

PMC3699881.

Prenatal cadmium exposure alters postnatal immune cell development and function.
Hanson ML, Holaskova I, Elliott M, Brundage KM, Schafer R, Barnett JB.
Toxicol Appl Pharmacol. 2012;261(2):196-203.

PMC3358511.

Prenatal cadmium exposure produces persistent changes to thymus and spleen cell phenotypic repertoire as well as the acquired immune response.
Holaskova I, Elliott M, Hanson ML, Schafer R, Barnett JB.
Toxicol Appl Pharmacol. 2012;265(2):181-189.

PMC3508345.

Cadmium increases HIF-1 and VEGF expression through ROS, ERK, and AKT signaling pathways and induces malignant transformation of human bronchial epithelial cells.
Jing Y, Liu LZ, Jiang Y, Zhu Y, Guo NL, Barnett JB, Rojanasakul Y, Agani FH, Jiang BH.
Toxicol Sci. 2012;125(1):10-19.

PMC3243743.

Multifunctional role of Bcl-2 in malignant transformation and tumorigenesis of Cr(VI)-transformed lung cells.
Medan D, Luanpitpong S, Azad N, Wang LY, Jiang BH, Davis ME, Barnett JB, Guo NL, Rojanasakul Y.
PLoS One. 2012;7(5):e37045

PMC3362580.

Gene disruption of the calcium channel Orai1 results in inhibition of osteoclast and osteoblast differentiation and impairs skeletal development.
Robinson LJ, Mancarella S, Songsawad D, Tourkova IL, Barnett JB, Gill DL, Soboloff J, Blair HC.
Lab Invest. 2012;92(7):1071-1083.

PMC3387291.

Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells.
Stueckle TA, Lu Y, Davis ME, Wang LY, Jiang BH, Holaskova I, Schafer R, Barnett JB, Rojanasakul Y.
Toxicol Appl Pharmacol. 2012;261(2):204-216.

PMC3358533.

The role of calcium release activated calcium channels in osteoclast differentiation.
Zhou Y, Lewis TL, Robinson LJ, Brundage KM, Schafer R, Martin KH, Blair HC, Soboloff J, Barnett JB.
J Cell Physiol. 2011;226(4):1082-1089.

PMC4020518.

Evaluating macrophages in immunotoxicity testing.
Barnett JB, Brundage KM.
Methods Mol Biol. 2010;598:75-94.


Interleukin 12 a key immunoregulatory cytokine in infection applications.
Hamza T, Barnett JB, Li BY.
Int J Mol Sci. 2010;11(3):789-806.

PMC2869233.

Subcellular localization of the amide class herbicide 3,4-dichloropropionanilide (DCPA) in T cells and hepatocytes.
Hanson ML, Peer CJ, Brundage RA, Callery PS, Brundage KM, Schafer R, Eremin S, Barnett JB.
J Toxicol Environ Health A. 2010;73(1):1-4.

PMC2888467.

Prenatal cadmium exposure dysregulates sonic hedgehog and Wnt/beta-catenin signaling in the thymus resulting in altered thymocyte development.
Hanson ML, Brundage KM, Schafer R, Tou JC, Barnett JB.
Toxicol Appl Pharmacol. 2010;242(2):136-145.

PMC2789900.

Regulation of bone turnover by calcium-regulated calcium channels.
Robinson LJ, Blair HC, Barnett JB, Zaidi M, Huang CL.
Ann NY Acad Sci. 2010;1192:351-357.


Modulating temporal control of NF-kappaB activation: implications for therapeutic and assay selection.
Klinke DJ, Ustyugova IV, Brundage KM, Barnett JB.
Biophys J. 2008;94(11):4249-4259.

PMC2480691.

3,4-Dichloropropionanilide (DCPA) inhibits T-cell activation by altering the intracellular calcium concentration following store depletion.
Lewis TL, Brundage KM, Brundage RA, Barnett JB.
Toxicol Sci. 2008;103(1):97-107.


In vitro nephrotoxicity induced by propanil.
Rankin GO, Racine C, Sweeney A, Kraynie A, Anestis DK, Barnett JB.
Environ Toxicol. 2008;23(4):435-442.


Developmental immunotoxicity of atrazine in rodents.
Rowe AM, Brundage KM, Barnett JB.
Basic Clin Pharmacol Toxicol. 2008;102(2):139-145.


A review of the immunotoxicity of the pesticide 3,4-dichloropropionanalide.
Salazar KD, Ustyugova IV, Brundage KM, Barnett JB, Schafer R.
J Toxicol Environ Health B Crit Rev. 2008;11(8):630-645.


In vitro atrazine-exposure inhibits human natural killer cell lytic granule release.
Rowe AM, Brundage KM, Barnett JB.
Toxicol Appl Pharmacol. 2007;221(2):179-188.

PMC1950779.

3,4-dichloropropionaniline suppresses normal macrophage function.
Ustyugova IV, Frost LL, Van Dyke K, Brundage KM, Schafer R, Barnett JB.
Toxicol Sci. 2007;97(2):364-374.


A novel role for 3, 4-dichloropropionanilide (DCPA) in the inhibition of prostate cancer cell migration, proliferation, and hypoxia-inducible factor 1alpha expression.
Jiang BH, Liu LZ, Schafer R, Flynn DC, Barnett JB.
BMC Cancer. 2006;6:204

PMC1555598.

Immunomodulatory effects of maternal atrazine exposure on male Balb/c mice.
Rowe AM, Brundage KM, Schafer R, Barnett JB.
Toxicol Appl Pharmacol. 2006;214(1):69-77.

PMC2034295.

Evidence for a novel endocrine disruptor: the pesticide propanil requires the ovaries and steroid synthesis to enhance humoral immunity.
Salazar KD, Miller MR, Barnett JB, Schafer R.
Toxicol Sci. 2006;93(1):62-74.


Propanil exposure induces delayed but sustained abrogation of cell-mediated immunity through direct interference with cytotoxic T-lymphocyte effectors.
Sheil JM, Frankenberry MA, Schell TD, Brundage KM, Barnett JB.
Environ Health Perspect. 2006;114(7):1059-1064.

PMC1513295.

Characterization of thymic atrophy and the mechanism of thymocyte depletion after in vivo exposure to a mixture of herbicides.
de la Rosa P, Barnett JB, Schafer R.
J Toxicol Environ Health A. 2005;68(2):81-98.


The polysaccharide antibody response after Streptococcus pneumoniae vaccination is differentially enhanced or suppressed by 3,4-dichloropropionanilide and 2,4-dichlorophenoxyacetic acid.
Salazar KD, de la Rosa P, Barnett JB, Schafer R.
Toxicol Sci. 2005;87(1):123-133.


Altered AP-1 (activating protein-1) activity and c-jun activation in T cells exposed to the amide class herbicide 3,4-dichloropropionanilide (DCPA).
Brundage KM, Schafer R, Barnett JB.
Toxicol Sci. 2004;79(1):98-105.


Production of macrophage IL-1beta was inhibited both at the levels of transcription and maturation by caspase-1 following inhalation exposure to isobutyl nitrite.
Soderberg LS, Ponnappan U, Roy A, Schafer R, Barnett JB.
Toxicol Lett. 2004;152(1):47-56.


The amide class herbicide 3,4-dichloropropionanilide (DCPA) alters the mobility of hydrocarbon chains in T-lymphocyte but not macrophage membranes.
Brundage KM, Barnett JB, Mahaney JE.
J Toxicol Environ Health A. 2003;66(23):2253-2265.


Loss of pre-B and IgM(+) B cells in the bone marrow after exposure to a mixture of herbicides.
de la Rosa P, Barnett JB, Schafer R.
J Toxicol Environ Health A. 2003;66(24):2299-2313.


Propanil inhibits tumor necrosis factor-alpha production by reducing nuclear levels of the transcription factor nuclear factor-kappab in the macrophage cell line ic-21.
Frost LL, Neeley YX, Schafer R, Gibson LF, Barnett JB.
Toxicol Appl Pharmacol. 2001;172(3):186-193.


Acute exposure to the abused inhalant, isobutyl nitrite, reduced T cell responsiveness and spleen cellularity.
Guo GL, Rose D, Flick JT, Barnett JB, Soderberg LS.
Toxicol Lett. 2000;116(1-2):151-158.


Nitrite inhalants spontaneously liberate nitric oxide, which is not responsible for the immunotoxicity in C57BL/6 mice.
Soderberg LS, Roy A, Flick JT, Barnett JB.
Int J Immunopharmacol. 2000;22(2):151-157.


In vivo cytokine production and resistance to infection after acute exposure to 3,4-dichloropropionaniline.
Watson VA, Barnett JB, Schafer R.
J Toxicol Environ Health A. 2000;60(6):391-406.


Propanil affects transcriptional and posttranscriptional regulation of IL-2 expression in activated EL-4 cells.
Zhao W, Schafer R, Barnett JB.
Toxicol Appl Pharmacol. 1999;154(2):153-159.


Enteric reovirus infection as a probe to study immunotoxicity of the gastrointestinal tract.
Cuff CF, Fulton JR, Barnett JB, Boyce CS.
Toxicol Sci. 1998;42(2):99-108.


Isobutyl nitrite liberates nitric oxide which is not responsible for the immunotoxicity of the inhalant.
Soderberg LS, Roy A, Barnett JB.
Adv Exp Med Biol. 1998;437:265-268.


Cytokine production by C57BL/6 mouse spleen cells is selectively reduced by exposure to propanil.
Zhao W, Schafer R, Barnett JB.
J Toxicol Environ Health A. 1998;55(2):107-120.


Inhibitory effect of 3,4-dichloro-propionaniline on cytokine production by macrophages is associated with LPS-mediated signal transduction.
Xie YC, Schafer R, Barnett JB.
J Leukoc Biol. 1997;61(6):745-752.


The immunomodulatory effects of the herbicide propanil on murine macrophage interleukin-6 and tumor necrosis factor-alpha production.
Xie YC, Schafer R, Barnett JB.
Toxicol Appl Pharmacol. 1997;145(1):184-191.


3,4-Dichloropropionanilide-induced atrophy of the thymus: mechanisms of toxicity and recovery.
Cuff CF, Zhao W, Nukui T, Schafer R, Barnett JB.
Fundam Appl Toxicol. 1996;33(1):83-90.


Inhaled isobutyl nitrite produced lung inflammation with increased macrophage TNF-alpha and nitric oxide production.
Soderberg LS, Chang LW, Barnett JB.
Adv Exp Med Biol. 1996;402:187-189.


Elevated TNF-alpha and inducible nitric oxide production by alveolar macrophages after exposure to a nitrite inhalant.
Soderberg LS, Chang LW, Barnett JB.
J Leukoc Biol. 1996;60(4):459-464.


Leukopenia and altered hematopoietic activity in mice exposed to the abused inhalant, isobutyl nitrite.
Soderberg LS, Flick JT, Barnett JB.
Exp Hematol. 1996;24(7):848-853.


Acute inhalation exposure to isobutyl nitrite causes nonspecific blood cell destruction.
Soderberg LS, Flick JT, Barnett JB.
Exp Hematol. 1996;24(5):592-596.


Inhalation exposure to isobutyl nitrite inhibits macrophage tumoricidal activity and modulates inducible nitric oxide.
Soderberg LS, Barnett JB.
J Leukoc Biol. 1995;57(1):135-140.


Possible mechanisms of immunotoxicity following in vivo exposure to the inhalant, isobutyl nitrite.
Soderberg LS, Barnett JB.
Adv Exp Med Biol. 1995;373:189-192.


Changes in primary and secondary lymphoid organ T-cell subpopulations resulting from acute in vivo exposure to propanil.
Zhao W, Schafer R, Cuff CF, Gandy J, Barnett JB.
J Toxicol Environ Health. 1995;46(2):171-181.


Gender-specific effects of prenatal chlordane exposure on myeloid cell development.
Blyler G, Landreth KS, Barnett JB.
Fundam Appl Toxicol. 1994;23(2):188-193.


Selective myelotoxicity of propanil.
Blyler G, Landreth KS, Lillis T, Schafer R, Theus SA, Gandy J, Barnett JB.
Fundam Appl Toxicol. 1994;22(4):505-510.


Inhaled isobutyl nitrite compromises T-dependent, but not T-independent, antibody induction.
Soderberg LS, Barnett JB.
Int J Immunopharmacol. 1993;15(7):821-827.


Exposure to the abused inhalant, isobutyl nitrite, compromises both antibody and cell-mediated immunity.
Soderberg LS, Barnett JB.
Adv Exp Med Biol. 1993;335:265-268.


Alteration of macrophage cytotoxicity through endogenous interferon and tumor necrosis factor alpha induction by propanil.
Theus SA, Tabor DR, Gandy J, Barnett JB.
Toxicol Appl Pharmacol. 1993;118(1):46-52.


Comparison of the immunotoxicity of propanil and its metabolite, 3,4-dichloroaniline, in C57Bl/6 mice.
Barnett JB, Gandy J, Wilbourn D, Theus SA.
Fundam Appl Toxicol. 1992;18(4):628-631.


Cytokine regulation of bone marrow natural suppressor cell activity in the suppression of lymphocyte function.
Moore SC, Theus SA, Barnett JB, Soderberg LS.
Cell Immunol. 1992;141(2):398-408.


Bone marrow natural suppressor cells inhibit the growth of myeloid progenitor cells and the synthesis of colony-stimulating factors.
Moore SC, Theus SA, Barnett JB, Soderberg LS.
Exp Hematol. 1992;20(10):1178-1183.


Macrophage tumoricidal mechanisms are selectively altered by prenatal chlordane exposure.
Theus SA, Tabor DR, Soderberg LS, Barnett JB.
Agents Actions. 1992;37(1-2):140-146.


In vivo prenatal chlordane exposure induces development of endogenous inflammatory macrophages.
Theus SA, Lau KA, Tabor DR, Soderberg LS, Barnett JB.
J Leukoc Biol. 1992;51(4):366-372.


Exposure to inhaled isobutyl nitrite reduces T cell blastogenesis and antibody responsiveness.
Soderberg LS, Barnett JB.
Fundam Appl Toxicol. 1991;17(4):821-824.


Inhaled isobutyl nitrite impairs T cell reactivity.
Soderberg LS, Barnett JB, Chang LW.
Adv Exp Med Biol. 1991;288:265-268.


Alteration of fetal liver colony formation by prenatal chlordane exposure.
Barnett JB, Blaylock BL, Gandy J, Menna JH, Denton R, Soderberg LS.
Fundam Appl Toxicol. 1990;15(4):820-822.


Long-term alteration of adult bone marrow colony formation by prenatal chlordane exposure.
Barnett JB, Blaylock BL, Gandy J, Menna JH, Denton R, Soderberg LS.
Fundam Appl Toxicol. 1990;14(4):688-695.


Cytotoxic T-lymphocyte and NK responses in mice treated prenatally with chlordane.
Blaylock BL, Soderberg LS, Gandy J, Menna JH, Denton R, Barnett JB.
Toxicol Lett. 1990;51(1):41-49.


Postirradiation treatment with copper(II)2(3,5-diisopropylsalicylate)4 enhances radiation recovery and hemopoietic regeneration.
Soderberg LS, Barnett JB, Baker ML, Salari H, Sorenson JR.
Exp Hematol. 1990;18(7):801-805.


Radiation recovery agents: Cu(II), Mn(II), Zn(II), or Fe(III) 3,5-diisopropylsalicylate complexes facilitate recovery from ionizing radiation induced radical mediated tissue damage.
Sorenson JJ, Soderberg LS, Baker ML, Barnett JB, Chang LW, Salari H, Willingham WM.
Adv Exp Med Biol. 1990;264:69-77.


Effect of acute propanil exposure on the immune response of C57Bl/6 mice.
Barnett JB, Gandy J.
Fundam Appl Toxicol. 1989;12(4):757-764.


Copper complexes stimulate hemopoiesis and lymphopoiesis.
Soderberg LS, Barnett JB, Sorenson JR.
Adv Exp Med Biol. 1989;258:209-217.


Copper(II)2(3,5-diisopropylsalicylate)4 stimulates hemopoiesis in normal and irradiated mice.
Soderberg LS, Barnett JB, Baker ML, Chang LW, Salari H, Sorenson JR.
Exp Hematol. 1988;16(7):577-580.


The effect of in utero exposure to hexachlorobenzene on the developing immune response of BALB/c mice.
Barnett JB, Barfield L, Walls R, Joyner R, Owens R, Soderberg LS.
Toxicol Lett. 1987;39(2-3):263-274.


Copper(II)(3,5-diisopropylsalicylate)2 accelerates recovery of B and T cell reactivity following irradiation.
Soderberg LS, Barnett JB, Baker ML, Salari H, Sorenson RJ.
Scand J Immunol. 1987;26(5):495-502.


The effect of prenatal chlordane exposure on specific anti-influenza cell-mediated immunity.
Barnett JB, Holcomb D, Menna JH, Soderberg LS.
Toxicol Lett. 1985;25(3):229-238.


The effect of prenatal chlordane exposure on the delayed hypersensitivity response of BALB/c mice.
Barnett JB, Soderberg LS, Menna JH.
Toxicol Lett. 1985;25(2):173-183.


Influenza type A virus infection of mice exposed in utero to chlordane; survival and antibody studies.
Menna JH, Barnett JB, Soderberg LS.
Toxicol Lett. 1985;24(1):45-52.