Publications of Vincent Castranova, PhD.

Effects of laser printer-emitted engineered nanoparticles on cytotoxicity, chemokine expression, reactive oxygen species, DNA methylation, and DNA damage: a comprehensive in vitro analysis in human small airway epithelial cells, macrophages, and lymphoblasts.
Pirela SV, Miousse IR, Lu X, Castranova V, Thomas T, Qian Y, Bello D, Kobzik L, Koturbash I, Demokritou P.
Environ Health Perspect. 2016;124(2):210-219.

PMC4749083.

mRNAs and miRNAs in whole blood associated with lung hyperplasia, fibrosis, and bronchiolo-alveolar adenoma and adenocarcinoma after multi-walled carbon nanotube inhalation exposure in mice.
Snyder-Talkington BN, Dong C, Sargent LM, Porter DW, Staska LM, Hubbs AF, Raese R, McKinney W, Chen BT, Battelli L, Lowry DT, Reynolds SH, Castranova V, Qian Y, Guo NL.
J Appl Toxicol. 2016;36(1):161-174.

PMC4418205.

mRNA and miRNA regulatory networks reflective of multi-walled carbon nanotube-induced lung inflammatory and fibrotic pathologies in mice.
Dymacek J, Snyder-Talkington BN, Porter DW, Mercer RR, Wolfarth MG, Castranova V, Qian Y, Guo NL.
Toxicol Sci. 2015;144(1):51-64.

PMC4349139.

Silica coating influences the corona and biokinetics of cerium oxide nanoparticles.
Konduru NV, Jimenez RJ, Swami A, Friend S, Castranova V, Demokritou P, Brain JD, Molina RM.
Part Fibre Toxicol. 2015;12(1):31

PMC4603643.

Effects of amorphous silica coating on cerium oxide nanoparticles induced pulmonary responses.
Ma J, Mercer RR, Barger M, Schwegler-Berry D, Cohen JM, Demokritou P, Castranova V.
Toxicol Appl Pharmacol. 2015;288(1):63-73.

PMC4579046.

Effects of nitrogen-doped multi-walled carbon nanotubes compared to pristine multi-walled carbon nanotubes on human small airway epithelial cells.
Mihalchik AL, Ding W, Porter DW, McLoughlin C, Schwegler-Berry D, Sisler JD, Stefaniak AB, Snyder-Talkington BN, Cruz-Silva R, Terrones M, Tsuruoka S, Endo M, Castranova V, Qian Y.
Toxicology. 2015;333:25-36.


Identification of TGF-beta receptor-1 as a key regulator of carbon nanotube-induced fibrogenesis.
Mishra A, Stueckle TA, Mercer RR, Derk R, Rojanasakul Y, Castranova V, Wang L.
Am J Physiol Lung Cell Mol Physiol. 2015;309(8):L821-L833.

PMC4609943.

Inhalation exposure to carbon nanotubes (CNT) and carbon nanofibers (CNF): methodology and dosimetry.
Oberdorster G, Castranova V, Asgharian B, Sayre P.
J Toxicol Environ Health B Crit Rev. 2015;18(3-4):121-212.

PMC4706753.

Consumer exposures to laser printer-emitted engineered nanoparticles: A case study of life-cycle implications from nano-enabled products.
Pirela SV, Sotiriou GA, Bello D, Shafer M, Bunker KL, Castranova V, Thomas T, Demokritou P.
Nanotoxicology. 2015;9(6):760-768.

PMC4671491.

Effects of laser printer-emitted engineered nanoparticles on cytotoxicity, chemokine expression, reactive oxygen species, DNA methylation, and DNA damage: a comprehensive analysis in human small airway epithelial cells, macrophages, and lymphoblasts.
Pirela SV, Miousse IR, Lu X, Castranova V, Thomas T, Qian Y, Bello D, Kobzik L, Koturbash I, Demokritou P.
Environ Health Perspect. 2015;


Evaluation of the pulmonary toxicity of ambient particulate matter from Camp Victory, Iraq.
Porter KL, Green FH, Harley RA, Vallyathan V, Castranova V, Waldron NR, Leonard SS, Nelson DE, Lewis JA, Jackson DA.
J Toxicol Environ Health A. 2015;78(23-24):1385-1408.

PMC4714599.

Effects of nickel-oxide nanoparticle pre-exposure dispersion status on bioactivity in the mouse lung.
Sager T, Wolfarth M, Keane M, Porter D, Castranova V, Holian A.
Nanotoxicology. 2015;1-11.


Small airway epithelial cells exposure to printer-emitted engineered nanoparticles induces cellular effects on human microvascular endothelial cells in an alveolar-capillary co-culture model.
Sisler JD, Pirela SV, Friend S, Farcas M, Schwegler-Berry D, Shvedova A, Castranova V, Demokritou P, Qian Y.
Nanotoxicology. 2015;9(6):769-779.


Multi-walled carbon nanotube-induced gene expression in vitro: concordance with in vivo studies.
Snyder-Talkington BN, Dong C, Zhao X, Dymacek J, Porter DW, Wolfarth MG, Castranova V, Qian Y, Guo NL.
Toxicology. 2015;328:66-74.

PMC4308557.

Differentiation of chemical reaction activity of various carbon nanotubes using redox potential: Classification by physical and chemical structures.
Tsuruoka S, Matsumoto H, Castranova V, Porter DW, Yanagisawa T, Saito N, Kobayashi S, Endo M.
Carbon. 2015;95:302-308.


Radical scavenging reaction kinetics with multiwalled carbon nanotubes.
Tsuruoka S, Matsumoto H, Koyama K, Akiba E, Yanagisawa T, Cassee FR, Saito N, Usui Y, Kobayashi S, Porter DW, Castranova V, Endo M.
Carbon. 2015;83:232-239.


Cardiovascular effects in rats after intratracheal instillation of metal welding particles.
Zheng W, Antonini JM, Lin YC, Roberts JR, Kashon ML, Castranova V, Kan H.
Inhal Toxicol. 2015;27(1):45-53.


The role of nodose ganglia in the regulation of cardiovascular function following pulmonary exposure to ultrafine titanium dioxide.
Kan H, Wu Z, Lin YC, Chen TH, Cumpston JL, Kashon ML, Leonard S, Munson AE, Castranova V.
Nanotoxicology. 2014;8:447-454.


Induction of stem-like cells with malignant properties by chronic exposure of human lung epithelial cells to single-walled carbon nanotubes.
Luanpitpong S, Wang LY, Castranova V, Rojanasakul Y.
Part Fibre Toxicol. 2014;11(1):22

PMC4040122.

Induction of stem-like cells with fibrogenic properties by carbon nanotubes and its role in fibrogenesis.
Luanpitpong S, Wang LY, Manke A, Castranova V, Yang Y, Martin KH, Ammer AG, Rojanasakul Y.
Nano Lett. 2014;14(6):3110-3116.

PMC4055043.

Interactive effects of cerium oxide and diesel exhaust nanoparticles on inducing pulmonary fibrosis.
Ma JY, Young SH, Mercer RR, Barger MW, Schwegler-Berry D, Ma JK, Castranova V.
Toxicol Appl Pharmacol. 2014;278(2):135-147.


Metallic nickel nanoparticles may exhibit higher carcinogenic potential than fine particles in JB6 cells.
Magaye R, Zhou Q, Bowman L, Zou B, Mao G, Xu J, Castranova V, Zhao J, Ding M.
PLoS One. 2014;9(4):e92418

PMC3972196.

Development and characterization of an exposure platform suitable for physico-chemical, morphological and toxicological characterization of printer-emitted particles (PEPs).
Pirela SV, Pyrgiotakis G, Bello D, Thomas T, Castranova V, Demokritou P.
Inhal Toxicol. 2014;26(7):400-408.

PMC4383100.

Alterations in cardiomyocyte function after pulmonary treatment with stainless steel welding fume in rats.
Popstojanov R, Antonini JM, Salmen R, Ye M, Zheng W, Castranova V, Fekedulegn DB, Kan H.
J Toxicol Environ Health A. 2014;77(12):705-715.


Promotion of lung adenocarcinoma following inhalation exposure to multi-walled carbon nanotubes.
Sargent LM, Porter DW, Staska LM, Hubbs AF, Lowry DT, Battelli LA, Siegrist KJ, Kashon ML, Mercer RR, Bauer AK, Chen BT, Salisbury JL, Frazer D, McKinney W, Andrew ME, Tsuruoka S, Endo M, Fluharty KL, Castranova V, Reynolds SH.
Part Fibre Toxicol. 2014;11(1):3

PMC3895742.

Occupational safety and health criteria for responsible development of nanotechnology.
Schulte PA, Geraci CL, Murashov V, Kuempel ED, Zumwalde RD, Castranova V, Hoover MD, Hodson L, Martinez KF.
J Nanopart Res. 2014;16:2153

PMC3890581.

Long-term effects of carbon containing engineered nanomaterials and asbestos in the lung: one year post exposure comparisons.
Shvedova AA, Yanamala N, Kisin ER, Tkach AV, Murray AR, Hubbs A, Chirila MM, Keohavong P, Sycheva LP, Kagan VE, Castranova V.
Am J Physiol Lung Cell Mol Physiol. 2014;306(2):L170-82.

PMC3920208.

Neoplastic-like transformation effect of single-walled and multi-walled carbon nanotubes compared to asbestos on human lung small airway epithelial cells.
Wang LY, Stueckle TA, Mishra A, Derk R, Meighan T, Castranova V, Rojanasakul Y.
Nanotoxicology. 2014;8(5):485-507.

PMC4599578.

Dispersion method for safety research on manufactured nanomaterials.
Wu W, Ichihara G, Suzuki Y, Izuoka K, Oikawa-Tada S, Chang J, Sakai K, Miyazawa K, Porter D, Castranova V, Kawaguchi M, Ichihara S.
Ind Health. 2014;52(1):54-65.

PMC4202770.

The Yin: An adverse health perspective of nanoceria: uptake, distribution, accumulation, and mechanisms of its toxicity.
Yokel RA, Hussain S, Garantziotis S, Demokritou P, Castranova V, Cassee FR.
Environ Sci Nano. 2014;1(5):406-428.

PMC4167411.

Interlaboratory evaluation of rodent pulmonary responses to engineered nanomaterials: The NIEHS NanoGo Consortium.
Bonner JC, Silva RM, Taylor AJ, Brown JM, Hilderbrand SC, Castranova V, Porter DW, Elder A, Oberdorster G, Harkema JR, Bramble LA, Kavanagh TJ, Botta D, Nel AE, Pinkerton KE.
Environ Health Perspect. 2013;121(6):676-682.

PMC3672912.

Occupational nanosafety considerations for carbon nanotubes and carbon nanofibers.
Castranova V, Schulte PA, Zumwalde RD.
Acc Chem Res. 2013;46(3):642-649.


An in vivo and in vitro toxicological characterisation of realistic nanoscale CeO(2) inhalation exposures.
Demokritou P, Gass S, Pyrgiotakis G, Cohen JM, Goldsmith W, McKinney W, Frazer D, Ma J, Schwegler-Berry D, Brain J, Castranova V.
Nanotoxicology. 2013;7:1338-1350.

PMC4438163.

Carbon nanotube dosimetry: from workplace exposure assessment to inhalation toxicology.
Erdely A, Dahm M, Chen BT, Zeidler-Erdely PC, Fernback JE, Birch ME, Evans DE, Kashon ML, Deddens JA, Hulderman T, Bilgesu SA, Battelli LA, Schwegler-Berry D, Leonard HD, McKinney W, Frazer DG, Antonini JM, Porter DW, Castranova V, Schubauer-Berigan MK.
Part Fibre Toxicol. 2013;10(1):53

PMC4015290.

Nanotechnology: toxicologic pathology.
Hubbs AF, Sargent LM, Porter DW, Sager TM, Chen BT, Frazer DG, Castranova V, Sriram K, Nurkiewicz TR, Reynolds SH, Battelli LA, Schwegler-Berry D, McKinney W, Fluharty KL, Mercer RR.
Toxicol Pathol. 2013;4(2):395-409.

PMC4665093.

Toxicity of lunar dust assessed in inhalation-exposed rats.
Lam CW, Scully RR, Zhang Y, Renne RA, Hunter RL, McCluskey RA, Chen BT, Castranova V, Driscoll KE, Gardner DE, McClellan RO, Cooper BL, McKay DS, Marshall L, James JT.
Inhal Toxicol. 2013;25(12):661-678.


Chronic exposure to carbon nanotubes induces invasion of human mesothelial cells through matrix netalloproteinase-2.
Lohcharoenkal W, Wang LY, Stueckle TA, Dinu CZ, Castranova V, Liu Y, Rojanasakul Y.
ACS Nano. 2013;24(7):7711-7723.

PMC3875633.

Extrapulmonary transport of MWCNT following inhalation exposure.
Mercer RR, Scabilloni JF, Hubbs AF, Wang LY, Battelli LA, McKinney W, Castranova V, Porter DW.
Part Fibre Toxicol. 2013;10(1):38

PMC3750633.

Distribution and fibrotic response following inhalation exposure to multi-walled carbon nanotubes.
Mercer RR, Scabilloni JF, Hubbs AF, Battelli LA, McKinney W, Friend S, Wolfarth MG, Andrew ME, Castranova V, Porter DW.
Part Fibre Toxicol. 2013;10(1):33

PMC3733770.

Oxidative stress and dermal toxicity of iron oxide nanoparticles in vitro.
Murray AR, Kisin E, Inman A, Young SH, Muhammed M, Burks T, Uheida A, Tkach A, Waltz M, Castranova V, Fadeel B, Kagan VE, Riviere JE, Monteiro-Riviere N, Shvedova AA.
Cell Biochem Biophys. 2013;67(2):461-476.


A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment.
Nel AE, Nasser E, Godwin H, Avery D, Bahadori T, Bergeson L, Beryt E, Bonner JC, Boverhof D, Carter J, Castranova V, Deshazo JR, Hussain SM, Kane AB, Klaessig F, Kuempel E, Lafranconi M, Landsiedel R, Malloy T, Miller MB, Morris J, Moss K, Oberdorster G, Pinkerton K, Pleus RC, Shatkin JA, Thomas R, Tolaymat T, Wang A, Wong J.
ACS Nano. 2013;7(8):6422-6433.

PMC4004078.

The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells.
Pacurari M, Addison JB, Bondalapati N, Wan YW, Luo D, Qian Y, Castranova V, Ivanov AV, Guo NL.
Int J Oncol. 2013;43(2):548-560.

PMC3775564.

Differential mouse pulmonary dose- and time course-responses to titanium dioxide nanospheres and nanobelts.
Porter DW, Wu NQ, Hubbs AF, Mercer R, Funk K, Meng F, Li J, Wolfarth M, Battelli LA, Friend S, Andrew ME, Hamilton R, Sriram K, Yang F, Castranova V, Holian A.
Toxicol Sci. 2013;131(1):179-193.

PMC3537123.

Acute pulmonary dose-responses to inhaled multi-walled carbon nanotubes.
Porter DW, Hubbs AF, Chen BT, McKinney W, Mercer RR, Wolfarth MG, Battelli LA, Wu NQ, Sriram K, Leonard S, Andrew ME, Willard P, Tsuruoka S, Endo M, Tsukada T, Munekane F, Frazer DG, Castranova V.
Nanotoxicology. 2013;7:1179-1194.


Pulmonary and cardiovascular responses of rats to inhalation of silver nanoparticles.
Roberts JR, McKinney W, Kan H, Krajnak K, Frazer DG, Thomas TA, Waugh S, Kenyon A, Maccuspie RI, Hackley VA, Castranova V.
J Toxicol Environ Health A. 2013;76(11):651-668.


Lung toxicity and biodistribution of Cd/Se-ZnS quantum dots with different surface functional groups after pulmonary exposure in rats.
Roberts JR, Antonini JM, Porter DW, Chapman RS, Scabilloni JF, Young SH, Schwegler-Berry D, Castranova V, Mercer RR.
Part Fibre Toxicol. 2013;10:5

PMC3599433.

Investigation of the pulmonary bioactivity of double-walled carbon nanotubes.
Sager TM, Wolfarth MW, Battelli LA, Leonard SS, Andrew ME, Steinbach T, Endo M, Tsuruoka S, Porter DW, Castranova V.
J Toxicol Environ Health A. 2013;76(15):922-936.


Titanium dioxide nanoparticles: a review of current toxicological data.
Shi H, Magaye R, Castranova V, Zhao J.
Part Fibre Toxicol. 2013;10(1):15

PMC3637140.

System-based identification of toxicity pathways associated with multi-walled carbon nanotube-induced pathological responses.
Snyder-Talkington BN, Dymacek J, Porter DW, Wolfarth MG, Mercer RR, Pacurari M, Denvir J, Castranova V, Qian Y, Guo NL.
Toxicol Appl Pharmacol. 2013;272(2):476-489.

PMC4017347.

Multi-walled carbon nanotubes induce human microvascular endothelial cellular effects in an alveolar-capillary co-culture with small airway epithelial cells.
Snyder-Talkington BN, Schwegler-Berry D, Castranova V, Qian Y, Guo NL.
Part Fibre Toxicol. 2013;10:35

PMC3750368.

Systematic analysis of multiwalled carbon nanotube-induced cellular signaling and gene expression in human small airway epithelial cells.
Snyder-Talkington BN, Pacurari M, Dong C, Leonard SS, Schwegler-Berry D, Castranova V, Qian Y, Guo NL.
Toxicol Sci. 2013;133(1):79-89.

PMC3627550.

Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells.
Tkach AV, Yanamala N, Stanley S, Shurin MR, Shurin GV, Kisin ER, Murray AR, Pareso S, Khaliullin T, Kotchey GP, Castranova V, Mathur S, Fadeel B, Star A, Kagan VE, Shvedova AA.
Small. 2013;9(9-10):1686-1690.

PMC4009732.

A new approach to design safe CNTs with an understanding of redox potential.
Tsuruoka S, Cassee FR, Castranova V.
Part Fibre Toxicol. 2013;10(1):44

PMC3848781.

Whole-body nanoparticle aerosol inhalation exposures.
Yi J, Chen BT, Schwegler-Berry D, Frazer D, Castranova V, McBride C, Knuckles TL, Stapleton PA, Minarchick VC, Nurkiewicz TR.
J Vis Exp. 2013;(75)

PMC3679583.

Apoptosis induced by tungsten carbide-cobalt nanoparticles in JB6 cells involves ROS generation through both extrinsic and intrinsic apoptosis pathways.
Zhao J, Bowman L, Magaye R, Leonard SS, Castranova V, Ding M.
Int J Oncol. 2013;42(4):1349-1359.


Single cell gel electrophoresis assay (comet assay) for evaluating nanoparticles-induced DNA damage in cells.
Bowman L, Castranova V, Ding M.
Methods Mol Biol. 2012;906:415-422.


Multi-walled carbon nanotubes: sampling criteria and aerosol characterization.
Chen BT, Schwegler-Berry D, McKinney W, Stone S, Cumpston JL, Friend S, Porter DW, Castranova V, Frazer DG.
Inhal Toxicol. 2012;24(12):798-820.


Luciferase reporter system for studying the effect of nanoparticles on gene expression.
Ding M, Bowman L, Castranova V.
Methods Mol Biol. 2012;906:403-414.


Apaf-1 deficiency confers resistance to ultraviolet-induced apoptosis in mouse embryonic fibroblasts by disrupting reactive oxygen species amplification production and mitochondrial pathway.
Feng R, Han J, Ziegler J, Yang M, Castranova V.
Free Radic Biol Med. 2012;52(5):889-897.


Multiwalled carbon nanotube-induced gene signatures in the mouse lung: potential predictive value for human lung cancer risk and prognosis.
Guo NL, Wan YW, Denvir J, Porter DW, Pacurari M, Wolfarth MG, Castranova V, Qian Y.
J Toxicol Environ Health A. 2012;75(18):1129-1153.

PMC3422779.

Respiratory and olfactory cytotoxicity of inhaled 2,3-pentanedione in Sprague-Dawley rats.
Hubbs AF, Cumpston AM, Goldsmith WT, Battelli LA, Kashon ML, Jackson MC, Frazer DG, Fedan JS, Goravanahally MP, Castranova V, Kreiss K, Willard PA, Friend S, Schwegler-Berry D, Fluharty KL, Sriram K.
Am J Pathol. 2012;181(3):829-844.


Pulmonary exposure of rats to ultrafine titanium dioxide enhances cardiac protein phosphorylation and substance P synthesis in nodose ganglia.
Kan H, Wu Z, Young SH, Chen TH, Cumpston JL, Chen F, Kashon ML, Castranova V.
Nanotoxicology. 2012;6:736-745.


Nanoparticle inhalation alters systemic arteriolar vasoreactivity through sympathetic and cyclooxygenase-mediated pathways.
Knuckles TL, Yi J, Frazer DG, Leonard HD, Chen BT, Castranova V, Nurkiewicz TR.
Nanotoxicology. 2012;6:724-735.


Development of risk-based nanomaterial groups for occupational exposure control.
Kuempel ED, Castranova V, Geraci CL, Schulte PA.
J Nanopart Res. 2012;14(9):1029-1043.


Defective calcium inactivation causes long QT in obese insulin-resistant rat.
Lin YC, Huang J, Kan H, Castranova V, Frisbee JC, Yu HG.
Am J Physiol Heart Circ Physiol. 2012;302(4):H1013-H1022.

PMC3322732.

Induction of pulmonary fibrosis by cerium oxide nanoparticles.
Ma JY, Mercer RR, Barger MW, Schwegler-Berry D, Scabilloni J, Ma JK, Castranova V.
Toxicol Appl Pharmacol. 2012;


Pulmonary and cardiovascular responses of rats to inhalation of a commercial antimicrobial spray containing titanium dioxide nanoparticles.
McKinney W, Jackson M, Sager TM, Reynolds JS, Chen BT, Afshari A, Krajnak K, Waugh S, Johnson C, Mercer RR, Frazer DG, Thomas TA, Castranova V.
Inhal Toxicol. 2012;24(7):447-457.


Assessment of pulmonary fibrogenic potential of multiwalled carbon nanotubes in human lung cells.
Mishra A, Rojanasakul Y, Chen BT, Castranova V, Mercer RR, Wang LY.
J Nanomater. 2012;Article 930931


Single-cell gel electrophoresis (Comet) assay in nano-genotoxicology.
Pacurari M, Castranova V.
Methods Mol Biol. 2012;926:57-67.


Cell permeability, migration, and reactive oxygen species induced by multiwalled carbon nanotubes in human microvascular endothelial cells.
Pacurari M, Qian Y, Fu W, Schwegler-Berry D, Ding M, Castranova V, Guo NL.
J Toxicol Environ Health A. 2012;75(2):112-128.

PMC3230883.

Pulmonary toxicity, distribution, and clearance of intratracheally instilled silicon nanowires in rats.
Roberts JR, Mercer RR, Chapman RS, Cohen GM, Bangsaruntip S, Schwegler-Berry D, Scabilloni JF, Castranova V, Antonini JM, Leonard SS.
J Nanomater. 2012;Article 398302


Focused actions to protect carbon nanotube workers.
Schulte PA, Kuempel ED, Zumwalde RD, Geraci CL, Schubauer-Berigan MK, Castranova V, Hodson L, Murashov V, Dahm MM, Ellenbecker M.
Am J Ind Med. 2012;55(5):395-411.


New perspectives for in vitro risk assessment of multiwalled carbon nanotubes: application of coculture and bioinformatics.
Snyder-Talkington BN, Qian Y, Castranova V, Guo NL.
J Toxicol Environ Health B Crit Rev. 2012;15(7):468-492.

PMC3513758.

Impairment of coronary arteriolar endothelium-dependent dilation after multi-walled carbon nanotube inhalation: a time-course study.
Stapleton PA, Minarchick VC, Cumpston AM, McKinney W, Chen BT, Sager TM, Frazer DG, Mercer RR, Scabilloni J, Andrew ME, Castranova V, Nurkiewicz TR.
Int J Mol Sci. 2012;13(11):13781-13803.

PMC3509550.

A smoking-associated 7-gene signature for lung cancer diagnosis and prognosis.
Wan YW, Raese RA, Fortney JE, Xiao C, Luo D, Cavendish J, Gibson LF, Castranova V, Qian Y, Guo NL.
Int J Oncol. 2012;41(4):1387-1396.

PMC3481011.

miR-190-Mediated downregulation of PHLPP contributes to arsenic-induced Akt activation and carcinogenesis.
Beezhold KJ, Liu J, Kan H, Meighan T, Castranova V, Shi X, Chen F.
Toxicol Sci. 2011;123(2):411-420.

PMC3179680.

Bioactivity of oil dispersant used in the deepwater horizon cleanup operation.
Castranova V.
J Toxicol Environ Health A. 2011;74(21):1367


Overview of current toxicological knowledge of engineered nanoparticles.
Castranova V.
J Occup Environ Med. 2011;53(6 Suppl):S14-7


Identification of systemic markers from a pulmonary carbon nanotube exposure.
Erdely A, Liston A, Salmen-Muniz R, Hulderman T, Young SH, Zeidler-Erdely PC, Castranova V, Simeonova PP.
J Occup Environ Med. 2011;53(6 Suppl):S80-S86.


Nanotoxicology--a pathologist's perspective.
Hubbs AF, Mercer RR, Benkovic SA, Harkema J, Sriram K, Schwegler-Berry D, Goravanahally MP, Nurkiewicz TR, Castranova V, Sargent LM.
Toxicol Pathol. 2011;39(2):301-324.


Genotoxicity of carbon nanofibers: Are they potentially more or less dangerous than carbon nanotubes or asbestos?
Kisin ER, Murray AR, Sargent LM, Lowry D, Chirila M, Siegrist KJ, Schwegler-Berry D, Leonard S, Castranova V, Fadeel B, Kagan VE, Shvedova AA.
Toxicol Appl Pharmacol. 2011;252(1):1-10.


Acute effects of COREXIT EC9500A on cardiovascular functions in rats.
Krajnak K, Kan H, Waugh S, Miller GR, Johnson C, Roberts JR, Goldsmith WT, Jackson M, McKinney W, Frazer D, Kashon ML, Castranova V.
J Toxicol Environ Health A. 2011;74(21):1397-1404.


Cerium oxide nanoparticle-induced pulmonary inflammation and alveolar macrophage functional change in rats.
Ma JY, Zhao H, Mercer RR, Barger MW, Rao M, Meighan T, Schwegler-Berry D, Castranova V, Ma JK.
Nanotoxicology. 2011;5:312-325.


Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes.
Mercer RR, Hubbs AF, Scabilloni JF, Wang LY, Battelli LA, Friend S, Castranova V, Porter DW.
Part Fibre Toxicol. 2011;8:21

PMC3152886.

Pulmonary particulate matter and systemic microvascular dysfunction.
Nurkiewicz TR, Porter DW, Hubbs AF, Stone S, Moseley AM, Cumpston JL, Goodwill AG, Frisbee SJ, Perrotta PL, Brock RW, Frisbee JC, Boegehold MA, Frazer DG, Chen BT, Castranova V, HEI Health Review Committee.
Res Rep Health Eff Inst. 2011;(164):3-48.


Raw single-walled carbon nanotube-induced cytotoxic effects in human bronchial epithelial cells: comparison to asbestos.
Pacurari M, Schwegler-Berry D, Friend S, Leonard SS, Mercer RR, Vallyathan V, Castranova V.
Toxicol Environ Chem. 2011;93(5):1045-1072.


Multi-walled carbon nanotube-induced gene expression in the mouse lung: association with lung pathology.
Pacurari M, Qian Y, Porter DW, Wolfarth M, Wan Y, Luo D, Ding M, Castranova V, Guo NL.
Toxicol Appl Pharmacol. 2011;255(1):18-31.

PMC3148292.

Pulmonary effects after acute inhalation of oil dispersant (COREXIT EC9500A) in rats.
Roberts JR, Reynolds JS, Thompson JA, Zaccone EJ, Shimko MJ, Goldsmith WT, Jackson M, McKinney W, Frazer DG, Kenyon A, Kashon ML, Piedimonte G, Castranova V, Fedan JS.
J Toxicol Environ Health A. 2011;74(21):1381-1396.


Nanomaterials in humans: identification, characteristics, and potential damage.
Song Y, Li X, Wang LY, Rojanasakul Y, Castranova V, Li H, Ma J.
Toxicol Pathol. 2011;39(5):841-849.


Neurotoxicity following acute inhalation exposure to the oil dispersant COREXIT EC9500A.
Sriram K, Lin GX, Jefferson AM, Goldsmith WT, Jackson M, McKinney W, Frazer DG, Robinson VA, Castranova V.
J Toxicol Environ Health A. 2011;74(21):1405-1418.


Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells.
Wang LY, Luanpitpong S, Castranova V, Tse WW, Lu Y, Pongrakhananon V, Rojanasakul Y.
Nano Lett. 2011;11(7):2796-2803.

PMC3135732.

Dispersal state of multiwalled carbon nanotubes elicits profibrogenic cellular responses that correlate with fibrogenesis biomarkers and fibrosis in the murine lung.
Wang X, Xia T, Addo NS, Ji Z, Lin S, Meng H, Chung CH, George S, Zhang H, Wang M, Li N, Yang Y, Castranova V, Mitra S, Bonner JC, Nel AE.
ACS Nano. 2011;5(12):9772-9787.

PMC4136431.

Decreased dissolution of ZnO by iron doping yields nanoparticles with reduced toxicity in the rodent lung and zebrafish embryos.
Xia T, Zhao Y, Sager T, George S, Pokhrel S, Li N, Schoenfeld D, Meng H, Lin S, Wang X, Wang M, Ji Z, Zink JI, Madler L, Castranova V, Lin S, Nel AE.
ACS Nano. 2011;5(2):1223-1235.

PMC3900638.

Pulmonary inflammation induced by office dust and the relation to 1 3--glucan using different extraction techniques.
Young SH, Cox-Ganser JM, Shogren ES, Wolfarth MG, Li SQ, Antonini JM, Castranova V, Park JH.
Toxicol Environ Chem. 2011;93(4):806-823.


Toxicology of nanomaterials used in nanomedicine.
Zhao J, Castranova V.
J Toxicol Environ Health B Crit Rev. 2011;14(8):593-632.


Nitric oxide-mediated bcl-2 stabilization potentiates malignant transformation of human lung epithelial cells.
Azad N, Iyer AK, Wang LY, Lu Y, Medan D, Castranova V, Rojanasakul Y.
Am J Respir Cell Mol Biol. 2010;42(5):578-585.

PMC2874443.

Role of oxidative/nitrosative stress-mediated Bcl-2 regulation in apoptosis and malignant transformation.
Azad N, Iyer AK, Vallyathan V, Wang LY, Castranova V, Stehlik C, Rojanasakul Y.
Ann NY Acad Sci. 2010;1203:1-6.


Microprocessor of microRNAs: regulation and potential for therapeutic intervention.
Beezhold KJ, Castranova V, Chen F.
Mol Cancer. 2010;9:134

PMC2887798.

Nanoparticles-containing spray can aerosol: characterization, exposure assessment, and generator design.
Chen BT, Afshari A, Stone S, Jackson M, Schwegler-Berry D, Frazer DG, Castranova V, Thomas TA.
Inhal Toxicol. 2010;22(13):1072-1082.


Challenges in assessing nanomaterial toxicology: a personal perspective.
Geraci CL, Castranova V.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010;2(6):569-577.


Nanoparticle inhalation impairs coronary microvascular reactivity via a local reactive oxygen species-dependent mechanism.
LeBlanc AJ, Moseley AM, Chen BT, Frazer DG, Castranova V, Nurkiewicz TR.
Cardiovasc Toxicol. 2010;10(1):27-36.

PMC2825710.

Phosphatidylinositol-3-kinase/akt regulates bleomycin-induced fibroblast proliferation and collagen production.
Lu YJ, Azad N, Wang LY, Iyer AK, Castranova V, Jiang BH, Rojanasakul Y.
Am J Respir Cell Mol Biol. 2010;42(4):432-441.

PMC2848736.

Distribution and persistence of pleural penetrations by multi-walled carbon nanotubes.
Mercer RR, Hubbs AF, Scabilloni JF, Wang LY, Battelli LA, Schwegler-Berry D, Castranova V, Porter DW.
Part Fibre Toxicol. 2010;7:28

PMC2958975.

Pulmonary inflammation after intraperitoneal administration of ultrafine titanium dioxide (TiO2) at rest or in lungs primed with lipopolysaccharide.
Moon C, Park HJ, Choi YH, Park EM, Castranova V, Kang JL.
J Toxicol Environ Health A. 2010;73(5):396-409.


DNA double-strand breaks by asbestos, silica, and titanium dioxide: possible biomarker of carcinogenic potential?
Msiska Z, Pacurari M, Mishra A, Leonard SS, Castranova V, Vallyathan V.
Am J Respir Cell Mol Biol. 2010;43(2):210-219.


Single- and multi-wall carbon nanotubes versus asbestos: are the carbon nanotubes a new health risk to humans?
Pacurari M, Castranova V, Vallyathan V.
J Toxicol Environ Health A. 2010;73(5):378-395.


Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes.
Porter DW, Hubbs AF, Mercer RR, Wu NQ, Wolfarth MG, Sriram K, Leonard SS, Battelli LA, Schwegler-Berry D, Friend S, Andrew ME, Chen BT, Tsuruoka S, Endo M, Castranova V.
Toxicology. 2010;269(2-3):136-147.


Perfluorooctane sulfonate (PFOS) induces reactive oxygen species (ROS) production in human microvascular endothelial cells: role in endothelial permeability.
Qian Y, Ducatman AM, Ward R, Leonard SS, Bukowski VC, Guo NL, Shi XL, Vallyathan V, Castranova V.
J Toxicol Environ Health A. 2010;73(12):819-836.

PMC3107001.

A population-based gene signature is predictive of breast cancer survival and chemoresponse.
Rathnagiriswaran S, Wan YW, Abraham J, Castranova V, Qian Y, Guo NL.
Int J Oncol. 2010;36(3):607-616.

PMC3103999.

Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics.
Rushton EK, Jiang J, Leonard SS, Eberly S, Castranova V, Biswas P, Elder A, Han X, Gelein R, Finkelstein J, Oberdorster G.
J Toxicol Environ Health A. 2010;73(5):445-461.

PMC3884809.

Potential pulmonary effects of engineered carbon nanotubes: in vitro genotoxic effects.
Sargent LM, Reynolds SH, Castranova V.
Nanotoxicology. 2010;4:396-408.


Effects of titanium dioxide nanoparticle exposure on neuroimmune responses in rat airways.
Scuri M, Chen BT, Castranova V, Reynolds JS, Johnson VJ, Samsell L, Walton C, Piedimonte G.
J Toxicol Environ Health A. 2010;73(20):1353-1369.

PMC3655524.

Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes.
Sriram K, Lin GX, Jefferson AM, Roberts JR, Wirth O, Hayashi Y, Krajnak KM, Soukup JM, Ghio AJ, Reynolds SH, Castranova V, Munson AE, Antonini JM.
FASEB J. 2010;24(12):4989-5002.


A breast cancer prognostic signature predicts clinical outcomes in multiple tumor types.
Wan YW, Qian Y, Rathnagiriswaran S, Castranova V, Guo NL.
Oncol Rep. 2010;24(2):489-494.

PMC3095949.

Hybrid models identified a 12-gene signature for lung cancer prognosis and chemoresponse prediction.
Wan YW, Sabbagh E, Raese RA, Qian Y, Luo D, Denvir J, Vallyathan V, Castranova V, Guo NL.
PLoS One. 2010;5(8):e12222

PMC2923187.

Direct fibrogenic effects of dispersed single-walled carbon nanotubes on human lung fibroblasts.
Wang LY, Mercer RR, Rojanasakul Y, Qiu AJ, Lu YJ, Scabilloni JF, Wu NQ, Castranova V.
J Toxicol Environ Health A. 2010;73(5):410-422.


Dispersion of single-walled carbon nanotubes by a natural lung surfactant for pulmonary in vitro and in vivo toxicity studies.
Wang LY, Castranova V, Mishra A, Chen B, Mercer RR, Schwegler-Berry D, Rojanasakul Y.
Part Fibre Toxicol. 2010;7:31-41.

PMC2970581.

Quantitative techniques for assessing and controlling the dispersion and biological effects of multiwalled carbon nanotubes in mammalian tissue culture cells.
Wang X, Xia T, Ntim SA, Ji Z, George S, Meng H, Zhang H, Castranova V, Mitra S, Nel AE.
ACS Nano. 2010;4:7241-7252.

PMC3899393.

Tungsten carbide-cobalt particles activate Nrf2 and its downstream target genes in JB6 cells possibly by ROS generation.
Zhang XD, Zhao JS, Bowman LL, Shi XG, Castranova V, Ding M.
J Environ Pathol Toxicol Oncol. 2010;29(1):31-40.


Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling.
Apopa PL, Qian Y, Shao R, Guo NL, Schwegler-Berry D, Pacurari M, Porter DW, Shi XL, Vallyathan V, Castranova V, Flynn DC.
Part Fibre Toxicol. 2009;6:1

PMC2632982.

Toxicology of nanomaterials: permanent interactive learning.
Borm PJ, Castranova V.
Part Fibre Toxicol. 2009;6:28

PMC2774283.

Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer.
Chang QS, Zhang Y, Beezhold KJ, Bhatia D, Zhao H, Chen J, Castranova V, Shi XL, Chen F.
J Hepatol. 2009;50(2):323-333.

PMC4417500.

JNK1 activation predicts the prognostic outcome of the human hepatocellular carcinoma.
Chang QS, Chen J, Beezhold KJ, Castranova V, Shi XL, Chen F.
Mol Cancer. 2009;8:64

PMC2732591.

JNK1, a Potential Therapeutic Target for Hepatocellular Carcinoma.
Chen F, Beezhold KJ, Castranova V.
Biochim Biophys Acta. 2009;1796(2):242-251.


Beyond apoptosis of JNK1 in liver cancer.
Chen F, Castranova V.
Cell Cycle. 2009;8(8):1145-1147.


Overlapping signature genes between hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
Chen F, Li S, Castranova V.
Eur J Gastroenterol Hepatol. 2009;21(11):1320-1321.


Signature genes for both hepatoblastoma and hepatocellular carcinoma.
Chen F, Li S, Castranova V.
Eur J Gastroenterol Hepatol. 2009;21(10):1220-1222.


Size-dependent effects of tungsten carbide-cobalt particles on oxygen radical production and activation of cell signaling pathways in murine epidermal cells.
Ding M, Kisin ER, Zhao J, Bowman LL, Lu Y, Jiang BH, Leonard SS, Vallyathan V, Castranova V, Murray AR, Fadeel B, Shvedova AA.
Toxicol Appl Pharmacol. 2009;241(3):260-268.


The limits of testing particle-mediated oxidative stress in vitro in predicting diverse pathologies; relevance for testing of nanoparticles.
Donaldson K, Borm PJ, Castranova V, Gulumian M.
Part Fibre Toxicol. 2009;6:13

PMC2685764.

Cross-talk between lung and systemic circulation during carbon nanotube respiratory exposure. Potential biomarkers.
Erdely A, Hulderman T, Salmen R, Liston A, Zeidler-Erdely PC, Schwegler-Berry D, Castranova V, Koyama S, Kim YA, Endo M, Simeonova PP.
Nano Lett. 2009;9(1):36-43.


Coal dust alters beta-naphthoflavone-induced aryl hydrocarbon receptor nuclear translocation in alveolar type II cells.
Ghanem MM, Battelli LA, Law BF, Castranova V, Kashon ML, Nath J, Hubbs AF.
Part Fibre Toxicol. 2009;6:21

PMC2732588.

The role of p53 in silica-induced cellular and molecular responses associated with carcinogenesis.
Gwinn MR, Leonard SS, Sargent LM, Lowry DT, McKinstry KT, Meighan T, Reynolds SH, Kashon ML, Castranova V, Vallyathan V.
J Toxicol Environ Health A. 2009;72(23):1509-1519.


Nanoparticle inhalation impairs endothelium-dependent vasodilation in subepicardial arterioles.
LeBlanc AJ, Cumpston JL, Chen BT, Frazer DG, Castranova V, Nurkiewicz TR.
J Toxicol Environ Health A. 2009;72(24):1576-1584.

PMC2808198.

Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3.
Lu Y, Chang QS, Zhang Y, Beezhold KJ, Rojanasakul Y, Zhao H, Castranova V, Shi XL, Chen F.
Cell Cycle. 2009;8(13)


An integrative genomic and proteomic approach to chemosensitivity prediction.
Ma Y, Ding ZY, Qian Y, Wan YW, Tosun K, Shi XL, Castranova V, Harner EJ, Guo NL.
Int J Oncol. 2009;34(1):107-115.

PMC2667126.

Oxidative stress and inflammatory response in dermal toxicity of single-walled carbon nanotubes.
Murray AR, Kisin E, Leonard SS, Young SH, Kommineni C, Kagan VE, Castranova V, Shvedova AA.
Toxicology. 2009;257(3):161-171.


Understanding biophysicochemical interactions at the nano-bio interface.
Nel AE, Madler L, Velegol D, Xia T, Hoek EM, Somasundaran P, Klaessig F, Castranova V, Thompson M.
Nat Mater. 2009;8(7):543-557.


Pulmonary nanoparticle exposure disrupts systemic microvascular nitric oxide signaling.
Nurkiewicz TR, Porter DW, Hubbs AF, Stone S, Chen BT, Frazer DG, Boegehold MA, Castranova V.
Toxicol Sci. 2009;110(1):191-203.

PMC2696324.

The soluble nickel component of residual oil fly ash alters pulmonary host defense in rats.
Roberts JR, Young SH, Castranova V, Antonini JM.
J Immunotoxicol. 2009;6(1):49-61.


Surface area of particle administered versus mass in determining the pulmonary toxicity of ultrafine and fine carbon black: comparison to ultrafine titanium dioxide.
Sager TM, Castranova V.
Part Fibre Toxicol. 2009;6:15

PMC2681444.

Mechanisms of pulmonary toxicity and medical applications of carbon nanotubes: Two faces of Janus?
Shvedova AA, Kisin ER, Porter D, Schulte P, Kagan VE, Fadeel B, Castranova V.
Pharmacol Ther. 2009;121(2):192-204.


Characterization of an alternatively spliced GADD45alpha, GADD45alpha1 isoform, in arsenic-treated epithelial cells.
Zhang Y, Beezhold KJ, Castranova V, Shi XL, Chen F.
Mol Carcinog. 2009;48(5):454-464.

PMC2680285.

Reactive oxygen species- and nitric oxide-mediated lung inflammation and mitochondrial dysfunction in wild-type and iNOS-deficient mice exposed to diesel exhaust particles.
Zhao HW, Ma JK, Barger MW, Mercer RR, Millecchia LL, Schwegler-Berry D, Castranova V, Ma JY.
J Toxicol Environ Health A. 2009;72(8):560-570.


Metallic nickel nano- and fine particles induce JB6 cell apoptosis through a caspase-8/AIF mediated cytochrome c-independent pathway.
Zhao J, Bowman LL, Zhang X, Shi XL, Jiang BH, Castranova V, Ding M.
J Nanobiotechnology. 2009;7:2

PMC2673202.

Titanium dioxide (TiO2) nanoparticles induce JB6 cell apoptosis through activation of the caspase-8/Bid and mitochondrial pathways.
Zhao J, Bowman LL, Zhang X, Vallyathan V, Young SH, Castranova V, Ding M.
J Toxicol Environ Health A. 2009;72(19):1141-1149.


Occupational toxicology of nickel and nickel compounds.
Zhao J, Shi X, Castranova V, Ding M.
J Environ Pathol Toxicol Oncol. 2009;28(3):177-208.


Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential--a workshop report and consensus statement.
Ayres JG, Borm PJ, Cassee FR, Castranova V, Donaldson K, Ghio A, Harrison RM, Hider R, Kelly F, Kooter IM, Marano F, Maynard RL, Mudway I, Nel A, Sioutas C, Smith S, Baeza-Squiban A, Cho A, Duggan S, Froines J.
Inhal Toxicol. 2008;20(1):75-99.


Aerosolization of single-walled carbon nanotubes for an inhalation study.
Baron PA, Deye GJ, Chen BT, Schwegler-Berry DE, Shvedova AA, Castranova V.
Inhal Toxicol. 2008;20(8):751-760.


Tumor promoting or tumor suppressing of NF-kappa B, a matter of cell context dependency.
Chen F, Beezhold KJ, Castranova V.
Int Rev Immunol. 2008;27(4):183-204.


Confirmation of gene expression-based prediction of survival in non-small cell lung cancer.
Guo NL, Wan YW, Tosun K, Lin H, Msiska Z, Flynn DC, Remick SC, Vallyathan V, Dowlati A, Shi XL, Castranova V, Beer DG, Qian Y.
Clin Cancer Res. 2008;14(24):8213-8220.

PMC2605664.

Respiratory toxicologic pathology of inhaled diacetyl in sprague-dawley rats.
Hubbs AF, Goldsmith WT, Kashon ML, Frazer DG, Mercer RR, Battelli LA, Kullman GJ, Schwegler-Berry D, Friend S, Castranova V.
Toxicol Pathol. 2008;36(2):330-344.


Re: Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube.
Ichihara G, Castranova V, Tanioka A, Miyazawa K.
J Toxicol Sci. 2008;33(3):381-382.


Three-dimensional localization and quantification of PAF-induced gap formation in intact venular microvessels.
Jiang Y, Wen K, Zhou XD, Schwegler-Berry D, Castranova V, He P.
Am J Physiol Heart Circ Physiol. 2008;295(2):H898-H906.

PMC2519217.

Comparison of the biological activity between ultrafine and fine titanium dioxide particles in RAW 264.7 cells associated with oxidative stress.
Kang JL, Moon C, Lee HS, Lee HW, Park EM, Kim HS, Castranova V.
J Toxicol Environ Health A. 2008;71(8):478-485.


Alteration of deposition pattern and pulmonary response as a result of improved dispersion of aspirated single-walled carbon nanotubes in a mouse model.
Mercer RR, Scabilloni J, Wang LY, Kisin E, Murray AR, Schwegler-Berry D, Shvedova AA, Castranova V.
Am J Physiol Lung Cell Mol Physiol. 2008;294(1):L87-L97.


Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction.
Nurkiewicz TR, Porter DW, Hubbs AF, Cumpston JL, Chen BT, Frazer DG, Castranova V.
Part Fibre Toxicol. 2008;5:1

PMC2276228.

Raw single-wall carbon nanotubes induce oxidative stress and activate MAPKs, AP-1, NF-kappaB, and Akt in normal and malignant human mesothelial cells.
Pacurari M, Yin XJ, Zhao J, Ding M, Leonard SS, Schwegler-Berry D, Ducatman BS, Sbarra D, Hoover MD, Castranova V, Vallyathan V.
Environ Health Perspect. 2008;116(9):1211-1217.

PMC2535624.

Pulmonary response to intratracheal instillation of ultrafine versus fine titanium dioxide: role of particle surface area.
Sager TM, Kommineni C, Castranova V.
Part Fibre Toxicol. 2008;5:17

PMC2633346.

Pharmacologic effects of grain weevil extract on isolated guinea pig tracheal smooth muscle.
Schachter EN, Zuskin E, Arumugam U, Goswami S, Castranova V, Whitmer M, Chiarelli A.
Lung. 2008;186(5):317-321.


Options for occupational health surveillance of workers potentially exposed to engineered nanoparticles: state of the science.
Schulte PA, Trout D, Zumwalde RD, Kuempel E, Geraci CL, Castranova V, Mundt DJ, Mundt KA, Halperin WE.
J Occup Environ Med. 2008;50(5):517-526.


Sharpening the focus on occupational safety and health in nanotechnology.
Schulte PA, Geraci C, Zumwalde RD, Hoover M, Castranova V, Kuempel E, Murashov V, Vainio H, Savolainen K.
Scand J Work Environ Health. 2008;34(6):471-478.


Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubes.
Shvedova AA, Kisin ER, Murray AR, Kommineni C, Castranova V, Fadeel B, Kagan VE.
Toxicol Appl Pharmacol. 2008;231(2):235-240.


Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity.
Shvedova AA, Fabisiak JP, Kisin ER, Murray AR, Roberts JR, Tyurina YY, Antonini JM, Feng WH, Kommineni C, Reynolds J, Barchowsky A, Castranova V, Kagan VE.
Am J Respir Cell Mol Biol. 2008;38(5):579-590.

PMC2335338.

Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis.
Shvedova AA, Kisin E, Murray AR, Johnson VJ, Gorelik O, Arepalli S, Hubbs AF, Mercer RR, Keohavong P, Sussman N, Jin J, Yin J, Stone S, Chen BT, Deye G, Maynard A, Castranova V, Baron PA, Kagan VE.
Am J Physiol Lung Cell Mol Physiol. 2008;295(4):L552-L565.

PMC2575941.

Peroxide is a key mediator of Bcl-2 down-regulation and apoptosis induction by cisplatin in human lung cancer cells.
Wang LY, Chanvorachote P, Toledo D, Stehlik C, Mercer RR, Castranova V, Rojanasakul Y.
Mol Pharmacol. 2008;73(1):119-127.


Incorporation of an internal ribosome entry site-dependent mechanism in arsenic-induced GADD45 alpha expression.
Chang QS, Bhatia D, Zhang Y, Meighan T, Castranova V, Shi XL, Chen F.
Cancer Res. 2007;67(13):6146-6154.


Nuclear factor-kappaB, an unappreciated tumor suppressor.
Chen F, Castranova V.
Cancer Res. 2007;67(23):11093-11098.


Individualized survival and treatment response predictions for breast cancers using phospho-EGFR, phospho-ER, phospho-HER2/neu, phospho-IGF-IR/In, phospho-MAPK, and phospho-p70S6K proteins.
Guo NL, Abraham J, Flynn DC, Castranova V, Shi XL, Qian Y.
Int J Biol Markers. 2007;22(1):1-11.


Population-based molecular prognosis of breast cancer by transcriptional profiling.
Ma Y, Qian Y, Wei L, Abraham J, Shi XL, Castranova V, Harner EJ, Flynn DC, Guo NL.
Clin Cancer Res. 2007;13(7):2014-2022.


Pulmonary toxicity of Expancel microspheres in the rat.
Porter DW, Hubbs AF, Baron PA, Millecchia LL, Wolfarth MG, Battelli LA, Schwegler-Berry DE, Beighley CM, Andrew ME, Castranova V.
Toxicol Pathol. 2007;35(5):702-714.


Identification of a novel domain at the N terminus of caveolin-1 that controls rear polarization of the protein and caveolae formation.
Sun XH, Flynn DC, Castranova V, Millecchia LL, Beardsley AR, Liu J.
J Biol Chem. 2007;282(10):7232-7241.


Loss of Ikkbeta promotes migration and proliferation of mouse embryo fibroblast cells.
Chen F, Lu Y, Castranova V, Li Z, Karin M.
J Biol Chem. 2006;281(48):37142-37149.


Finding NEMO by K63-linked polyubiquitin chain.
Chen F, Bhatia D, Chang QS, Castranova V.
Cell Death Differ. 2006;13(11):1835-1838.


Involvement of protein kinase C in crystalline silica-induced activation of the MAP kinase and AP-1 pathway.
Ding M, Huang C, Lu Y, Bowman LL, Castranova V, Vallyathan V.
Am J Physiol Lung Cell Mol Physiol. 2006;290(2):L291-L297.


Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity.
Ding M, Feng R, Wang SY, Bowman LL, Lu Y, Qian Y, Castranova V, Jiang BH, Shi XL.
J Biol Chem. 2006;281(25):17359-17368.


Constructing molecular classifiers for the accurate prognosis of lung adenocarcinoma.
Guo NL, Ma Y, Ward R, Castranova V, Shi XL, Qian Y.
Clin Cancer Res. 2006;12(11 Pt 1):3344-3354.


Predicting cancer drug response by proteomic profiling.
Ma Y, Ding Z, Qian Y, Shi XL, Castranova V, Harner EJ, Guo NL.
Clin Cancer Res. 2006;12(15):4583-4589.


Systemic microvascular dysfunction and inflammation after pulmonary particulate matter exposure.
Nurkiewicz TR, Porter DW, Barger MW, Millecchia LL, Rao KM, Marvar PJ, Hubbs AF, Castranova V, Boegehold MA.
Environ Health Perspect. 2006;114(3):412-419.

PMC1392236.

Nitric oxide and reactive oxygen species production causes progressive damage in rats after cessation of silica inhalation.
Porter DW, Millecchia LL, Willard P, Robinson VA, Ramsey D, McLaurin J, Khan A, Brumbaugh K, Beighley CM, Teass A, Castranova V.
Toxicol Sci. 2006;90(1):188-197.


Welding fume exposure and associated inflammatory and hyperplastic changes in the lungs of tumor susceptible a/j mice.
Solano-Lopez C, Zeidler-Erdely PC, Hubbs AF, Reynolds SH, Roberts JR, Taylor MD, Young SH, Castranova V, Antonini JM.
Toxicol Pathol. 2006;34(4):364-372.


Role of lung surfactant in phagocytic clearance of apoptotic cells by macrophages in rats.
Wang LY, Scabilloni JF, Antonini JM, Castranova V, Rojanasakul Y, Roberts JR, Zhang Z, Mercer RR.
Lab Invest. 2006;86(5):458-466.


Induction of secondary apoptosis, inflammation, and lung fibrosis after intratracheal instillation of apoptotic cells in rats.
Wang LY, Scabilloni JF, Antonini JM, Rojanasakul Y, Castranova V, Mercer RR.
Am J Physiol Lung Cell Mol Physiol. 2006;290(4):L695-L702.


Nucleolin links to arsenic-induced stabilization of GADD45alpha mRNA.
Zhang Y, Bhatia D, Xia H, Castranova V, Shi X, Chen F.
Nucleic Acids Res. 2006;34(2):485-495.

PMC1342039.

Loss of caveolin-1 polarity impedes endothelial cell polarization and directional movement.
Beardsley AR, Fang K, Mertz H, Castranova V, Friend S, Liu J.
J Biol Chem. 2005;280(5):3541-3547.


Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid.
Feng R, Lu Y, Bowman LL, Qian Y, Castranova V, Ding M.
J Biol Chem. 2005;280(30):27888-27895.


Correlates of oxidative stress and free-radical activity in serum from asymptomatic shipyard welders.
Han SG, Kim Y, Kashon ML, Pack DL, Castranova V, Vallyathan V.
Am J Respir Crit Care Med. 2005;172(12):1541-1548.


Cdc42 regulates arsenic-induced NADPH oxidase activation and cell migration through actin filament reorganization.
Qian Y, Liu KJ, Chen Y, Flynn DC, Castranova V, Shi XL.
J Biol Chem. 2005;280(5):3875-3884.


Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice.
Shvedova AA, Kisin ER, Mercer R, Murray AR, Johnson VJ, Potapovich AI, Tyurina YY, Gorelik O, Arepalli S, Schwegler-Berry D, Hubbs AF, Antonini JM, Evans DE, Ku BK, Ramsey D, Maynard A, Kagan VE, Castranova V, Baron PA.
Am J Physiol Lung Cell Mol Physiol. 2005;289(5):L698-L708.


Essential role of p53 in silica-induced apoptosis.
Wang LY, Bowman LL, Lu Y, Rojanasakul Y, Mercer RR, Castranova V, Ding M.
Am J Physiol Lung Cell Mol Physiol. 2005;288(3):L488-L496.


The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer.
Zhang Y, Lu Y, Yuan BZ, Castranova V, Shi XL, Stauffer JL, Demers LM, Chen F.
Oncogene. 2005;24(31):4873-4882.


Deficiency in Ikkbeta gene enhances arsenic-induced gadd45alpha expression.
Zhang Y, Lu Y, Ding M, Castranova V, Shi XL, Chen F.
Mol Cell Biochem. 2005;279(1-2):163-168.


fMLP-stimulated neutrophils increase endothelial [Ca2+]i and microvessel permeability in the absence of adhesion: role of reactive oxygen species.
Zhu L, Castranova V, He P.
Am J Physiol Heart Circ Physiol. 2005;288(3):H1331-H1338.


Inhibition of AP-1 and neoplastic transformation by fresh apple peel extract.
Ding M, Lu Y, Bowman LL, Huang C, Leonard SS, Wang LY, Vallyathan V, Castranova V, Shi XL.
J Biol Chem. 2004;279(11):10670-10676.


Blackberry extracts inhibit activating protein 1 activation and cell transformation by perturbing the mitogenic signaling pathway.
Feng R, Bowman LL, Lu Y, Leonard SS, Shi XL, Jiang BH, Castranova V, Vallyathan V, Ding M.
Nutr Cancer. 2004;50(1):80-89.


Respirable coal dust particles modify cytochrome P4501A1 (CYP1A1) expression in rat alveolar cells.
Ghanem MM, Porter DW, Battelli LA, Vallyathan V, Kashon ML, Ma JY, Barger MW, Nath J, Castranova V, Hubbs AF.
Am J Respir Cell Mol Biol. 2004;31(2):171-183.


Particulate matter exposure impairs systemic microvascular endothelium-dependent dilation.
Nurkiewicz TR, Porter DW, Barger MW, Castranova V, Boegehold MA.
Environ Health Perspect. 2004;112(13):1299-1306.

PMC1247520.

Progression of lung inflammation and damage in rats after cessation of silica inhalation.
Porter DW, Hubbs AF, Mercer R, Robinson VA, Ramsey D, McLaurin J, Khan A, Battelli LA, Brumbaugh K, Teass A, Castranova V.
Toxicol Sci. 2004;79(2):370-380.


Effect of diesel exhaust particulate (DEP) on immune responses: contributions of particulate versus organic soluble components.
Siegel PD, Saxena RK, Saxena QB, Ma JK, Ma JY, Yin XJ, Castranova V, Al-Humadi NH, Lewis DM.
J Toxicol Environ Health A. 2004;67(3):221-231.


Roles of reactive oxygen species and heme oxygenase-1 in modulation of alveolar macrophage-mediated pulmonary immune responses to Listeria monocytogenes by diesel exhaust particles.
Yin XJ, Ma JY, Antonini JM, Castranova V, Ma JK.
Toxicol Sci. 2004;82(1):143-153.


Role of inducible nitric oxide synthase-derived nitric oxide in silica-induced pulmonary inflammation and fibrosis.
Zeidler P, Hubbs AF, Battelli LA, Castranova V.
J Toxicol Environ Health A. 2004;67(13):1001-1026.


Time-dependent apoptosis of alveolar macrophages from rats exposed to bleomycin: involvement of tnf receptor 2.
Zhao HW, Hu SY, Barger MW, Ma JK, Castranova V, Ma JY.
J Toxicol Environ Health A. 2004;67(17):1391-1406.


Internalization of caveolin-1 scaffolding domain facilitated by Antennapedia homeodomain attenuates PAF-induced increase in microvessel permeability.
Zhu L, Schwegler-Berry D, Castranova V, He P.
Am J Physiol Heart Circ Physiol. 2004;286(1):H195-H201.


Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic.
Chen F, Castranova V, Li Z, Karin M, Shi X.
Cancer Res. 2003;63(22):7689-7693.


Inhalation exposure of rats to asphalt fumes generated at paving temperatures alters pulmonary xenobiotic metabolism pathways without lung injury.
Ma JY, Rengasamy A, Frazer DG, Barger MW, Hubbs AF, Battelli LA, Tomblyn S, Stone S, Castranova V.
Environ Health Perspect. 2003;111(9):1215-1221.

PMC1241577.

Diesel exhaust particle-induced alterations of pulmonary phase I and phase II enzymes of rats.
Rengasamy A, Barger MW, Kane E, Ma JK, Castranova V, Ma JY.
J Toxicol Environ Health A. 2003;66(2):153-167.


Asphalt exposure enhances neuropeptide levels in sensory neurons projecting to the rat nasal epithelium.
Sikora ER, Stone S, Tomblyn S, Frazer DG, Castranova V, Dey RD.
J Toxicol Environ Health A. 2003;66(11):1015-1027.


Vanadium-induced apoptosis and pulmonary inflammation in mice: Role of reactive oxygen species.
Wang LY, Medan D, Mercer RR, Overmiller D, Leornard S, Castranova V, Shi XL, Ding M, Huang C, Rojanasakul Y.
J Cell Physiol. 2003;195(1):99-107.


Potential role of apoptotic macrophages in pulmonary inflammation and fibrosis.
Wang LY, Antonini JM, Rojanasakul Y, Castranova V, Scabilloni JF, Mercer RR.
J Cell Physiol. 2003;194(2):215-224.


Response of alveolar macrophages from inducible nitric oxide synthase knockout or wild-type mice to an in vitro lipopolysaccharide or silica exposure.
Zeidler PC, Roberts JR, Castranova V, Chen F, Butterworth L, Andrew ME, Robinson VA, Porter DW.
J Toxicol Environ Health A. 2003;66(11):995-1013.


Pulmonary alterations associated with inhalation of occupational and environmental irritants.
Castranova V, Frazer DG, Manley LK, Dey RD.
Int Immunopharmacol. 2002;2(2-3):163-172.


Protective roles of NF-kappa B for chromium(VI)-induced cytotoxicity is revealed by expression of Ikappa B kinase-beta mutant.
Chen F, Bower JJ, Leonard SS, Ding M, Lu Y, Rojanasakul Y, Kung HF, Vallyathan V, Castranova V, Shi XL.
J Biol Chem. 2002;277(5):3342-3349.


Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway.
Chen F, Zhang Z, Bower JJ, Lu Y, Leonard SS, Ding M, Castranova V, Piwnica-Worms H, Shi XL.
Proc Natl Acad Sci USA. 2002;99(4):1990-1995.

PMC122307.

Differential role of hydrogen peroxide in UV-induced signal transduction.
Ding M, Li J, Leonard SS, Shi XL, Costa M, Castranova V, Vallyathan V, Huang C.
Mol Cell Biochem. 2002;234-235(1-2):81-90.


p38 Signaling-mediated hypoxia-inducible factor 1alpha and vascular endothelial growth factor induction by Cr(VI) in DU145 human prostate carcinoma cells.
Gao N, Jiang BH, Leonard SS, Corum L, Zhang Z, Roberts JR, Antonini JM, Zheng JZ, Flynn DC, Castranova V, Shi XL.
J Biol Chem. 2002;277(47):45041-45048.


Ultraviolet-induced phosphorylation of p70(S6K) at Thr(389) and Thr(421)/Ser(424) involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase C.
Huang C, Li J, Ke Q, Leonard SS, Jiang BH, Zhong XS, Costa M, Castranova V, Shi XL.
Cancer Res. 2002;62(20):5689-5697.


Antioxidant properties of fruit and vegetable juices: more to the story than ascorbic acid.
Leonard SS, Cutler D, Ding M, Vallyathan V, Castranova V, Shi XL.
Ann Clin Lab Sci. 2002;32(2):193-200.


Alteration of pulmonary cytochrome p-450 system: effects of asphalt fume condensate exposure.
Ma JY, Yang HM, Barger MW, Siegel PD, Zhong BZ, Kriech AJ, Castranova V.
J Toxicol Environ Health A. 2002;65(17):1247-1260.


Induction of neutrophil apoptosis and secondary necrosis during endotoxin-induced pulmonary inflammation in mice.
Medan D, Wang LY, Yang X, Dokka S, Castranova V, Rojanasakul Y.
J Cell Physiol. 2002;191(3):320-326.


Enhanced nitric oxide and reactive oxygen species production and damage after inhalation of silica.
Porter DW, Millecchia L, Robinson VA, Hubbs AF, Willard P, Pack D, Ramsey D, McLaurin J, Khan A, Landsittel D, Teass A, Castranova V.
Am J Physiol Lung Cell Mol Physiol. 2002;283(2):L485-L493.


Time course of pulmonary response of rats to inhalation of crystalline silica: NF-kappa B activation, inflammation, cytokine production, and damage.
Porter DW, Ye J, Ma J, Barger MW, Robinson VA, Ramsey DM, McLaurin JL, Khan A, Landsittel DP, Teass A, Castranova V.
Inhal Toxicol. 2002;14(4):349-367.


Role of neutrophil apoptosis in vanadium-induced pulmonary inflammation in mice.
Wang LY, Medan D, Mercer RR, Shi XL, Huang C, Castranova V, Ding M, Rojanasakul Y.
J Environ Pathol Toxicol Oncol. 2002;21(4):343-350.


Modified endotoxin responses in rats pretreated with 1-->3-beta-glucan (zymosan A).
Young SH, Robinson VA, Barger M, Zeidler P, Porter DW, Frazer DG, Castranova V.
Toxicol Appl Pharmacol. 2002;178(3):172-179.


Effect of exposure to diesel exhaust particles on the susceptibility of the lung to infection.
Castranova V, Ma JY, Yang HM, Antonini JM, Butterworth L, Barger MW, Roberts J, Ma JK.
Environ Health Perspect. 2001;109 Suppl 4:609-612.

PMC1240590.

Opposite effect of NF-kappa B and c-Jun N-terminal kinase on p53-independent GADD45 induction by arsenite.
Chen F, Lu Y, Zhang Z, Vallyathan V, Ding M, Castranova V, Shi XL.
J Biol Chem. 2001;276(14):11414-11419.


Carcinogenic metals and NF-kappaB activation.
Chen F, Ding M, Castranova V, Shi XL.
Mol Cell Biochem. 2001;222(1-2):159-171.


Induction of activator protein-1 through reactive oxygen species by crystalline silica in JB6 cells.
Ding M, Shi XL, Lu Y, Huang C, Leonard SS, Roberts J, Antonini JM, Castranova V, Vallyathan V.
J Biol Chem. 2001;276(12):9108-9114.


Interleukin-10-mediated inhibition of free radical generation in macrophages.
Dokka S, Shi XL, Leonard SS, Wang LY, Castranova V, Rojanasakul Y.
Am J Physiol Lung Cell Mol Physiol. 2001;280(6):L1196-L1202.


Transactivation of RARE and GRE in the cellular response to arsenic.
Huang C, Li J, Ding M, Costa M, Castranova V, Vallyathan V, Ju G, Shi XL.
Mol Cell Biochem. 2001;222(1-2):119-125.


Arsenic-induced NFkappaB transactivation through Erks- and JNKs-dependent pathways in mouse epidermal JB6 cells.
Huang C, Li J, Ding M, Wang LY, Shi XL, Castranova V, Vallyathan V, Ju G, Costa M.
Mol Cell Biochem. 2001;222(1-2):29-34.


Vanadium-induced nuclear factor of activated T cells activation through hydrogen peroxide.
Huang C, Ding M, Li J, Leonard SS, Rojanasakul Y, Castranova V, Vallyathan V, Ju G, Shi XL.
J Biol Chem. 2001;276(25):22397-22403.


Involvement of sphingomyelinase in insulin-induced phosphatidylinositol 3-kinase activation.
Huang C, Ma WY, Ding M, Li J, Shi XL, Castranova V, Vallyathan V, Bode AM, Dong ZG.
FASEB J. 2001;15(6):1113-1114.


UV Induces phosphorylation of protein kinase B (Akt) at Ser-473 and Thr-308 in mouse epidermal Cl 41 cells through hydrogen peroxide.
Huang C, Li J, Ding M, Leonard SS, Wang LY, Castranova V, Vallyathan V, Shi XL.
J Biol Chem. 2001;276(43):40234-40240.


Comparative pulmonary toxicity of 6 abrasive blasting agents.
Hubbs AF, Minhas NS, Jones W, Greskevitch M, Battelli LA, Porter DW, Goldsmith WT, Frazer DG, Landsittel DP, Ma JY, Barger MW, Hill K, Schwegler-Berry D, Robinson VA, Castranova V.
Toxicol Sci. 2001;61(1):135-143.


Time course of pulmonary response of rats to inhalation of crystalline silica: histological results and biochemical indices of damage, lipidosis, and fibrosis.
Porter DW, Ramsey D, Hubbs AF, Battelli L, Ma J, Barger M, Landsittel D, Robinson VA, McLaurin J, Khan A, Jones W, Teass A, Castranova V.
J Environ Pathol Toxicol Oncol. 2001;20 Suppl 1:1-14.


Reactive oxygen species and molecular mechanism of silica-induced lung injury.
Shi XL, Ding M, Chen F, Wang LY, Rojanasakul Y, Vallyathan V, Castranova V.
J Environ Pathol Toxicol Oncol. 2001;20 Suppl 1:85-93.


Diesel exhaust particles suppress macrophage function and slow the pulmonary clearance of Listeria monocytogenes in rats.
Yang HM, Antonini JM, Barger MW, Butterworth L, Roberts BR, Ma JK, Castranova V, Ma JY.
Environ Health Perspect. 2001;109(5):515-521.

PMC1240312.

Effect of silica inhalation on the pulmonary clearance of a bacterial pathogen in Fischer 344 rats.
Antonini JM, Roberts JR, Yang HM, Barger MW, Ramsey DM, Castranova V, Ma JY.
Lung. 2000;178(6):341-350.


Participation of MAP kinase p38 and IkappaB kinase in chromium (VI)-induced NF-kappaB and AP-1 activation.
Chen F, Ding M, Lu Y, Leonard SS, Vallyathan V, Castranova V, Shi XL.
J Environ Pathol Toxicol Oncol. 2000;19(3):231-238.


Impairment of NF-kappaB activation and modulation of gene expression by calpastatin.
Chen F, Demers LM, Vallyathan V, Lu Y, Castranova V, Shi XL.
Am J Physiol Cell Physiol. 2000;279(3):C709-C716.


Predisposing factors in occupational lung cancer: inorganic minerals and chromium.
Ding M, Shi XL, Castranova V, Vallyathan V.
J Environ Pathol Toxicol Oncol. 2000;19(1-2):129-138.


Oxygen radical-mediated pulmonary toxicity induced by some cationic liposomes.
Dokka S, Toledo D, Shi XL, Castranova V, Rojanasakul Y.
Pharm Res. 2000;17(5):521-525.


Inhibition of endotoxin-induced lung inflammation by interleukin-10 gene transfer in mice.
Dokka S, Malanga CJ, Shi XL, Chen F, Castranova V, Rojanasakul Y.
Am J Physiol Lung Cell Mol Physiol. 2000;279(5):L872-L877.


Vanadate induces p53 transactivation through hydrogen peroxide and causes apoptosis.
Huang C, Zhang Z, Ding M, Li J, Ye J, Leonard SS, Shen HM, Butterworth L, Lu Y, Costa M, Rojanasakul Y, Castranova V, Vallyathan V, Shi XL.
J Biol Chem. 2000;275(42):32516-32522.


Silica induces nuclear factor-kappa B activation through tyrosine phosphorylation of I kappa B-alpha in RAW264.7 macrophages.
Kang JL, Pack IS, Hong SM, Lee HS, Castranova V.
Toxicol Appl Pharmacol. 2000;169(1):59-65.


Effects of asphalt fume condensate exposure on acute pulmonary responses.
Ma JY, Barger MW, Kriech AJ, Castranova V.
Arch Toxicol. 2000;74(8):452-459.


Antioxidant properties of (-)-epicatechin-3-gallate and its inhibition of Cr(VI)-induced DNA damage and Cr(IV)- or TPA-stimulated NF-kappaB activation.
Shi XL, Ye J, Leonard SS, Ding M, Vallyathan V, Castranova V, Rojanasakul Y, Dong ZG.
Mol Cell Biochem. 2000;206(1-2):125-132.


Involvement of 5'-flanking kappaB-like sites within bcl-x gene in silica-induced Bcl-x expression.
Chen F, Demers LM, Vallyathan V, Lu Y, Castranova V, Shi XL.
J Biol Chem. 1999;274(50):35591-35595.


Vanadate induction of NF-kappaB involves IkappaB kinase beta and SAPK/ERK kinase 1 in macrophages.
Chen F, Demers LM, Vallyathan V, Ding M, Lu Y, Castranova V, Shi XL.
J Biol Chem. 1999;274(29):20307-20312.


Nitric oxide inhibits HIV tat-induced NF-kappaB activation.
Chen F, Lu Y, Castranova V, Rojanasakul Y, Miyahara K, Shizuta Y, Vallyathan V, Shi XL, Demers LM.
Am J Pathol. 1999;155(1):275-284.

PMC1866645.

Role of transcription factor NF-kappaB in asbestos-induced TNFalpha response from macrophages.
Cheng N, Shi XL, Ye J, Castranova V, Chen F, Leonard SS, Vallyathan V, Rojanasakul Y.
Exp Mol Pathol. 1999;66(3):201-210.


Freshly fractured crystalline silica induces activator protein-1 activation through ERKs and p38 MAPK.
Ding M, Shi XL, Dong ZG, Chen F, Lu Y, Castranova V, Vallyathan V.
J Biol Chem. 1999;274(43):30611-30616.


Vanadate-induced activation of activator protein-1: role of reactive oxygen species.
Ding M, Li JJ, Leonard SS, Ye JP, Shi XL, Colburn NH, Castranova V, Vallyathan V.
Carcinogenesis. 1999;20(4):663-668.


Asbestos induces activator protein-1 transactivation in transgenic mice.
Ding M, Dong ZG, Chen F, Pack DL, Ma WY, Ye J, Shi XL, Castranova V, Vallyathan V.
Cancer Res. 1999;59(8):1884-1889.


Use of tetrandrine to differentiate between mechanisms involved in silica-versus bleomycin-induced fibrosis.
Ma JY, Barger MW, Hubbs AF, Castranova V, Weber SL, Ma JK.
J Toxicol Environ Health A. 1999;57(4):247-266.


Dependence of NF-kappaB activation and free radical generation on silica-induced TNF-alpha production in macrophages.
Rojanasakul Y, Ye J, Chen F, Wang LY, Cheng N, Castranova V, Vallyathan V, Shi XL.
Mol Cell Biochem. 1999;200(1-2):119-125.


Antioxidant properties of aspirin: characterization of the ability of aspirin to inhibit silica-induced lipid peroxidation, DNA damage, NF-kappaB activation, and TNF-alpha production.
Shi XL, Ding M, Dong ZG, Chen F, Ye J, Wang S, Leonard SS, Castranova V, Vallyathan V.
Mol Cell Biochem. 1999;199(1-2):93-102.


Cr(IV) causes activation of nuclear transcription factor-kappa B, DNA strand breaks and dG hydroxylation via free radical reactions.
Shi XL, Ding M, Ye J, Wang S, Leonard SS, Zang L, Castranova V, Vallyathan V, Chiu A, Dalal NS, Liu K.
J Inorg Biochem. 1999;75(1):37-44.


The role of hydroxyl radical as a messenger in the activation of nuclear transcription factor NF-kappaB.
Shi XL, Dong ZG, Huang C, Ma W, Liu K, Ye J, Chen F, Leonard SS, Ding M, Castranova V, Vallyathan V.
Mol Cell Biochem. 1999;194(1-2):63-70.


Effects of diesel exhaust particles (DEP), carbon black, and silica on macrophage responses to lipopolysaccharide: evidence of DEP suppression of macrophage activity.
Yang HM, Barger MW, Castranova V, Ma JK, Yang JJ, Ma JY.
J Toxicol Environ Health A. 1999;58(5):261-278.


Role of reactive oxygen species and p53 in chromium(VI)-induced apoptosis.
Ye J, Wang S, Leonard SS, Sun Y, Butterworth L, Antonini JM, Ding M, Rojanasakul Y, Vallyathan V, Castranova V, Shi XL.
J Biol Chem. 1999;274(49):34974-34980.


Induction of TNFalpha in macrophages by vanadate is dependent on activation of transcription factor NF-kappaB and free radical reactions.
Ye J, Ding M, Zhang X, Rojanasakul Y, Nedospasov S, Vallyathan V, Castranova V, Shi XL.
Mol Cell Biochem. 1999;198(1-2):193-200.


Critical role of glass fiber length in TNF-alpha production and transcription factor activation in macrophages.
Ye J, Shi XL, Jones W, Rojanasakul Y, Cheng N, Schwegler-Berry D, Baron PA, Deye GJ, Li C, Castranova V.
Am J Physiol. 1999;276(3 Pt 1):L426-L434.


Vanadate induces apoptosis in epidermal JB6 P+ cells via hydrogen peroxide-mediated reactions.
Ye J, Ding M, Leonard SS, Robinson VA, Millecchia LL, Zhang X, Castranova V, Vallyathan V, Shi XL.
Mol Cell Biochem. 1999;202(1-2):9-17.


Enhancement of nitric oxide production by pulmonary cells following silica exposure.
Castranova V, Huffman LJ, Judy DJ, Bylander JE, Lapp LN, Weber SL, Blackford JA, Dey RD.
Environ Health Perspect. 1998;106 Suppl 5:1165-1169.

PMC1533358.

Role of hydroxyl radical in silica-induced NF-kappa B activation in macrophages.
Chen F, Lu Y, Demers LM, Rojanasakul Y, Shi X, Vallyathan V, Castranova V.
Ann Clin Lab Sci. 1998;28(1):1-13.


Effects of silica exposure on substance P immunoreactivity and preprotachykinin mRNA expression in trigeminal sensory neurons in Fischer 344 rats.
Hunter DD, Castranova V, Stanley CF, Dey RD.
J Toxicol Environ Health A. 1998;53(8):593-605.


Cobalt-mediated generation of reactive oxygen species and its possible mechanism.
Leonard SS, Gannett PM, Rojanasakul Y, Schwegler-Berry D, Castranova V, Vallyathan V, Shi X.
J Inorg Biochem. 1998;70(3-4):239-244.


Reactive oxygen species and silica-induced carcinogenesis.
Shi X, Castranova V, Halliwell B, Vallyathan V.
J Toxicol Environ Health B Crit Rev. 1998;1(3):181-197.


Comparison of inducible nitric oxide synthase gene expression and lung inflammation following intratracheal instillation of silica, coal, carbonyl iron, or titanium dioxide in rats.
Blackford JA, Jones W, Dey RD, Castranova V.
J Toxicol Environ Health. 1997;51(3):203-218.


Augmentation of pulmonary reactions to quartz inhalation by trace amounts of iron-containing particles.
Castranova V, Vallyathan V, Ramsey DM, McLaurin JL, Pack DL, Leonard SS, Barger MW, Ma JY, Dalal NS, Teass A.
Environ Health Perspect. 1997;105 Suppl 5:1319-1324.

PMC1470157.

Acute lung injury induced by a commercial leather conditioner.
Hubbs AF, Castranova V, Ma JY, Frazer DG, Siegel PD, Ducatman BS, Grote A, Schwegler-Berry D, Robinson VA, Van Dyke C, Barger MW, Xiang J, Parker J.
Toxicol Appl Pharmacol. 1997;143(1):37-46.


Antisense inhibition of silica-induced tumor necrosis factor in alveolar macrophages.
Rojanasakul Y, Weissman DN, Shi XL, Castranova V, Ma JK, Liang WW.
J Biol Chem. 1997;272(7):3910-3914.


Efficacy of taurine based compounds as hydroxyl radical scavengers in silica induced peroxidation.
Shi XL, Flynn DC, Porter DW, Leonard SS, Vallyathan V, Castranova V.
Ann Clin Lab Sci. 1997;27(5):365-374.


Effects of diesel exhaust particles on the release of interleukin-1 and tumor necrosis factor-alpha from rat alveolar macrophages.
Yang HM, Ma JY, Castranova V, Ma JK.
Exp Lung Res. 1997;23(3):269-284.


Pulmonary reactions to organic dust exposures: development of an animal model.
Castranova V, Robinson VA, Frazer DG.
Environ Health Perspect. 1996;104 Suppl 1:41-53.

PMC1469574.

Modification of alveolar macrophage function with bis-basic ethers of fluorene and fluoren-9-substituted derivatives.
Ma JY, Cheng YH, Barger MW, Xin WF, Lewis DM, Castranova V, Ma JK.
Exp Lung Res. 1995;21(5):771-790.


Fluoromicroscopic studies of bleomycin-induced intracellular oxidation in alveolar macrophages and its inhibition by taurine.
Bhat M, Rojanasakul Y, Weber SL, Ma JY, Castranova V, Banks DE, Ma JK.
Environ Health Perspect. 1994;102 Suppl 10:91-96.

PMC1567002.

Intratracheal instillation of silica up-regulates inducible nitric oxide synthase gene expression and increases nitric oxide production in alveolar macrophages and neutrophils.
Blackford JA, Antonini JM, Castranova V, Dey RD.
Am J Respir Cell Mol Biol. 1994;11(4):426-431.


Exposure of rats to hyperoxia: alteration of lavagate parameters and macrophage function.
Dedhia HV, Ma JY, Vallyathan V, Dalal NS, Banks DE, Flink EB, Billie M, Barger MW, Castranova V.
J Toxicol Environ Health. 1993;40(1):1-13.


Organic dust exposure from compost handling: response of an animal model.
Frazer DG, Jones WG, Petsonk EL, Kullman GJ, Barger MW, Afshari A, Jones T, Castranova V.
Am J Ind Med. 1993;24(4):375-385.


Inhibition of proliferative activity of pulmonary fibroblasts by tetrandrine.
Reist RH, Dey RD, Durham JP, Rojanasakul Y, Castranova V.
Toxicol Appl Pharmacol. 1993;122(1):70-76.


Inhibitory action of tetrandrine on macrophage production of interleukin-1 (IL-1)-like activity and thymocyte proliferation.
Kang JH, Lewis DM, Castranova V, Rojanasakul Y, Banks DE, Ma JY, Ma JK.
Exp Lung Res. 1992;18(5):715-729.


Effects of bisbenzylisoquinoline alkaloids on alveolar macrophages: correlation between binding affinity, inhibitory potency, and antifibrotic potential.
Castranova V, Kang JH, Ma JK, Mo CG, Malanga CJ, Moore MD, Schwegler-Berry D, Ma JY.
Toxicol Appl Pharmacol. 1991;108(2):242-252.


Binding of bisbenzylisoquinoline alkaloids to phosphatidylcholine vesicles and alveolar macrophages: relationship between binding affinity and antifibrogenic potential of these drugs.
Ma JK, Mo CG, Malanga CJ, Ma JY, Castranova V.
Exp Lung Res. 1991;17(6):1061-1077.


Generation of free radicals from freshly fractured silica dust. Potential role in acute silica-induced lung injury.
Vallyathan V, Shi XL, Dalal NS, Irr W, Castranova V.
Am Rev Respir Dis. 1988;138(5):1213-1219.