Publications of Christopher F. Cuff, PhD.

Sensitization of lung cancer cells to cisplatin by beta-elemene is mediated through blockade of cell cycle progression: antitumor efficacies of beta-elemene and its synthetic analogs.
Li QQ, Wang G, Huang F, Li JM, Cuff CF, Reed E.
Med Oncol. 2013;30(1):488

beta-Elemene and taxanes synergistically induce cytotoxicity and inhibit proliferation in ovarian cancer and other tumor cells.
Zou B, Li QQ, Zhao J, Li JM, Cuff CF, Reed E.
Anticancer Res. 2013;33(3):929-940.

Use of 16S ribosomal RNA gene analyses to characterize the bacterial signature associated with poor oral health in West Virginia.
Olson JC, Cuff CF, Lukomski S, Lukomska E, Canizales Y, Wu B, Crout RJ, Thomas JG, McNeil DW, Weyant RJ, Marazita ML, Paster BJ, Elliott T.
BMC Oral Health. 2011;11(1):7


Enteric reovirus infection stimulates peanut-specific IgG2a responses in a mouse food allergy model.
Fecek RJ, Marcondes RM, Busch R, Hassing I, Pieters R, Cuff CF.
Immunobiology. 2010;


Evaluation of cisplatin in combination with beta-Elemene as a regimen for prostate cancer chemotherapy.
Li QQ, Wang G, Reed E, Huang L, Cuff CF.
Basic Clin Pharmacol Toxicol. 2010;107(5):868-876.

Bacterial- and viral-induced inflammation increases sensitivity to acetaminophen hepatotoxicity.
Maddox JF, Amuzie CJ, Li MX, Newport SW, Sparkenbaugh E, Cuff CF, Pestka JJ, Cantor GH, Roth RA, Ganey PE.
J Toxicol Environ Health A. 2010;73(1):58-73.

beta-Elemene, a novel plant-derived antineoplastic agent, increases cisplatin chemosensitivity of lung tumor cells by triggering apoptosis.
Li QQ, Wang G, Zhang M, Cuff CF, Huang L, Reed E.
Oncol Rep. 2009;22(1):161-170.

Docosahexaenoic acid-enriched fish oil consumption modulates immunoglobulin responses to and clearance of enteric reovirus infection in mice.
Beli E, Li MX, Cuff CF, Pestka JJ.
J Nutr. 2008;138(4):813-819.

Deoxynivalenol exacerbates viral bronchopneumonia induced by respiratory reovirus infection.
Li M, Harkema JR, Cuff CF, Pestka JJ.
Toxicol Sci. 2007;95(2):412-426.

In vitro combination characterization of the new anticancer plant drug beta-elemene with taxanes against human lung carcinoma.
Zhao J, Li QQ, Zou B, Wang G, Li X, Kim JE, Cuff CF, Huang L, Reed E, Gardner K.
Int J Oncol. 2007;31(2):241-252.

Production of Alexa Fluor 488-labeled reovirus and characterization of target cell binding, competence, and immunogenicity of labeled virions.
Fecek RJ, Busch R, Lin H, Pal K, Cunningham CA, Cuff CF.
J Immunol Methods. 2006;314(1-2):30-37.

T-2 toxin impairment of enteric reovirus clearance in the mouse associated with suppressed immunoglobulin and IFN-gamma responses.
Li M, Cuff CF, Pestka JJ.
Toxicol Appl Pharmacol. 2006;214(3):318-325.

T-2 toxin impairs murine immune response to respiratory reovirus and exacerbates viral bronchiolitis.
Li M, Harkema JR, Islam Z, Cuff CF, Pestka JJ.
Toxicol Appl Pharmacol. 2006;217(1):76-85.

Modulation of murine host response to enteric reovirus infection by the trichothecene deoxynivalenol.
Li M, Cuff CF, Pestka JJ.
Toxicol Sci. 2005;87(1):134-145.

Regulation of polymeric immunoglobulin receptor expression by reovirus.
Pal K, Kaetzel CS, Brundage KM, Cunningham CA, Cuff CF.
J Gen Virol. 2005;86(Pt 8):2347-2357.

Influence of the route of infection on development of T-cell receptor beta-chain repertoires of reovirus-specific cytotoxic T lymphocytes.
Fulton JR, Smith J, Cunningham CA, Cuff CF.
J Virol. 2004;78(3):1582-1590.


Mucosal and systemic immunity to intestinal reovirus infection in aged mice.
Fulton JR, Cuff CF.
Exp Gerontol. 2004;39(9):1285-1294.

Role of interleukin-4 (IL-4) and IL-10 in serum immunoglobulin G antibody responses following mucosal or systemic reovirus infection.
Mathers AR, Cuff CF.
J Virol. 2004;78(7):3352-3360.


Histologic and immunologic observations of viral-induced rhinosinusitis in the mouse.
Ramadan HH, Meek RB, III, Dawson GS, Spirou GA, Cuff CF, Berrebi AS.
Am J Rhinol. 2002;16(1):61-67.

Distinct mechanisms for cross-protection of the upper versus lower respiratory tract through intestinal priming.
Zuercher AW, Jiang HQ, Thurnheer MC, Cuff CF, Cebra JJ.
J Immunol. 2002;169(7):3920-3925.

Reduced interleukin-8 production by cystic fibrosis airway epithelial cells.
Massengale AR, Quinn F, Jr., Yankaskas J, Weissman D, McClellan WT, Cuff CF, Aronoff SC.
Am J Respir Cell Mol Biol. 1999;20(5):1073-1080.

Immunologic and histologic observations in reovirus-induced otitis media in the mouse.
Meek RB, III, McGrew BM, Cuff CF, Berrebi AS, Spirou GA, Wetmore SJ.
Ann Otol Rhinol Laryngol. 1999;108(1):31-38.

Enteric reovirus infection as a probe to study immunotoxicity of the gastrointestinal tract.
Cuff CF, Fulton JR, Barnett JB, Boyce CS.
Toxicol Sci. 1998;42(2):99-108.

T-Helper 1 and T-helper 2 cytokine responses in gut-associated lymphoid tissue following enteric reovirus infection.
Fan JY, Boyce CS, Cuff CF.
Cell Immunol. 1998;188(1):55-63.

Mucosal immunity to reovirus infection.
Major AS, Rubin DH, Cuff CF.
Curr Top Microbiol Immunol. 1998;233(Pt 2):163-177.

Enhanced mucosal and systemic immune responses to intestinal reovirus infection in beta2-microglobulin-deficient mice.
Major AS, Cuff CF.
J Virol. 1997;71(8):5782-5789.


3,4-Dichloropropionanilide-induced atrophy of the thymus: mechanisms of toxicity and recovery.
Cuff CF, Zhao W, Nukui T, Schafer R, Barnett JB.
Fundam Appl Toxicol. 1996;33(1):83-90.

Effects of the route of infection on immunoglobulin G subclasses and specificity of the reovirus-specific humoral immune response.
Major AS, Cuff CF.
J Virol. 1996;70(9):5968-5974.


Development, function, and trafficking of mucosal leukocytes in immunodeficient mice.
Cuff CF, Rubin DH, Cebra JJ.
Adv Exp Med Biol. 1995;371B:719-724.

Morphologic and functional alterations of mucosal T cells by cholera toxin and its B subunit.
Elson CO, Holland SP, Dertzbaugh MT, Cuff CF, Anderson AO.
J Immunol. 1995;154(3):1032-1040.

Changes in primary and secondary lymphoid organ T-cell subpopulations resulting from acute in vivo exposure to propanil.
Zhao W, Schafer R, Cuff CF, Gandy J, Barnett JB.
J Toxicol Environ Health. 1995;46(2):171-181.

Development of components of the mucosal immune system in SCID recipient mice.
Cebra JJ, Bos NA, Cebra ER, Cuff CF, Deenen GJ, Kroese FG, Shroff KE.
Adv Exp Med Biol. 1994;355:255-259.

Developmental relationship between cytotoxic alpha/beta T cell receptor-positive intraepithelial lymphocytes and Peyer's patch lymphocytes.
Cuff CF, Cebra CK, Rubin DH, Cebra JJ.
Eur J Immunol. 1993;23(6):1333-1339.

Viral gastrointestinal infections.
Taterka JA, Cuff CF, Rubin DH.
Gastroenterol Clin North Am. 1992;21(2):303-330.

Relationship between alpha/beta T cell receptor/CD8+ precursors for cytotoxic T lymphocytes in the murine Peyer's patches and the intraepithelial compartment probed by oral infection with reovirus.
Cebra JJ, Cuff CF, Rubin DH.
Immunol Res. 1991;10(3-4):321-323.

Protection of neonatal mice from fatal reovirus infection by immune serum and gut derived lymphocytes.
Cuff CF, Cebra CK, Lavi E, Molowitz EH, Rubin DH, Cebra JJ.
Adv Exp Med Biol. 1991;310:307-315.

Passive immunity to fatal reovirus serotype 3-induced meningoencephalitis mediated by both secretory and transplacental factors in neonatal mice.
Cuff CF, Lavi E, Cebra CK, Cebra JJ, Rubin DH.
J Virol. 1990;64(3):1256-1263.


Reoviruses as probes of the gut mucosal T cell population.
Cebra JJ, Cebra-Thomas JA, Cuff CF, George A, Kost SI, London SD, Rubin DH.
Immunol Invest. 1989;18(1-4):545-558.

A further characterization of Candida albicans-induced suppressor B-cell activity.
Cuff CF, Packer BJ, Rogers TJ.
Immunology. 1989;68(1):80-86.


The induction of T-suppressor cells with a soluble extract of Candida albicans.
Cuff CF, Taub DD, Rogers TJ.
Cell Immunol. 1989;122(1):71-82.

Induction of immunosuppressive B-lymphocytes with components of Candida albicans.
Cuff CF, Packer BJ, Rivas V, Rogers CM, Cassone A, Donnelly R, Rogers TJ.
Adv Exp Med Biol. 1988;239:367-378.

Induction of suppressor cells in vitro by Candida albicans.
Cuff CF, Rogers CM, Lamb BJ, Rogers TJ.
Cell Immunol. 1986;100(1):47-56.