Publications of Laura F. Gibson, PhD

Bone marrow microenvironment modulation of acute lymphoblastic leukemia phenotype.
Moses BS, Slone WL, Thomas P, Evans R, Piktel D, Angel PM, Walsh CM, Cantrell PS, Rellick SL, Martin KH, Simpkins JW, Gibson LF.
Exp Hematol. 2016;44(1):50-59.

PMC4684957.

A novel method to assess bone marrow purity is useful in determining blast percentage by flow cytometry in Acute Myeloid Leukemia and Myelodysplasia.
Aldawood AM, Kinkade Z, Rosado FG, Esan OA, Gibson LF, Vos JA.
Anal Hematology & Oncology. 2015;2(5):1038

PMC4507808.

Three-dimensional microfluidic tri-culture model of the bone marrow microenvironment for study of acute lymphoblastic leukemia.
Bruce A, Evans R, Mezan R, Shi L, Moses BS, Martin KH, Gibson LF, Yang Y.
PLoS One. 2015;10(10):e0140506

PMC4619215.

Modeling the bone marrow microenvironment's influence on leukemic disease.
Evans R, Martin KH, Moses BS, Slone WL, Hare I, Piktel D, Thomas P, Gibson LF.
Transl Biomed. 2015;6(2):14

PMC4710364.

AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis.
Park J, Schlederer M, Schreiber M, Kim S, Ice RJ, Merkel O, Bilban M, Hofbauer S, Addison JB, Zou J, Ji CY, Bunting S, Wang Z, Shoham M, Huang G, Bago-Horvath Z, Gibson LF, Rojanasakul Y, Remick SC, Ivanov AV, Pugacheva EN, Bunting K, Moriggl R, Kenner L, Tse WW.
OncoTarget. 2015;6(24):20697-20710.

PMC4653036.

Extranodal Marginal Zone Lymphoma of the lung: evolution from an underlying reactive lymphoproliferative disorder.
Rubenstein JN, Beatty C, Kinkade Z, Bryan C, Hogg JP, Gibson LF, Vos JA.
J Clin Exp Pathol. 2015;5(1)

PMC4597786.

Breaking and entering into the CNS: clues from solid tumor and nonmalignant models with relevance to hematopoietic malignancies.
Basu SK, Remick SC, Monga M, Gibson LF.
Clin Exp Metastasis. 2014;31(2):257-267.

PMC4482126.

RepSox slows decay of CD34+ acute myeloid leukemia cells and decreasesT cell immunoglobulin mucin-3 expression.
Jajosky AN, Coad JE, Vos JA, Martin KH, Senft JR, Wenger SL, Gibson LF.
Stem Cells Transl Med. 2014;3(7):836-848.

PMC4073822.

Bone marrow osteoblast vulnerability to chemotherapy.
Gencheva M, Hare I, Kurian S, Fortney JE, Piktel D, Wysolmerski RB, Gibson LF.
Eur J Haematol. 2013;90(6):469-478.

PMC3662303.

Sibling donor and recipient immune modulation with atorvastatin for the prophylaxis of acute graft-versus-host disease.
Hamadani M, Gibson LF, Remick SC, Wen S, Petros WP, Tse WW, Brundage KM, Vos JA, Cumpston AD, Bunner P, Craig M.
J Clin Oncol. 2013;31(35):4416-4423.

PMC3842909.

Three-dimensional hierarchical plasmonic nano-architecture enhanced surface-enhanced Raman scattering immunosensor for cancer biomarker detection in blood plasma.
Li M, Cushing SK, Zhang J, Suri S, Evans R, Petros WP, Gibson LF, Ma D, Liu Y, Wu NQ.
ACS Nano. 2013;7(6):4967-4976.

PMC3732798.

Adipocytes as a critical component of the tumor microenvironment.
Vona-Davis LC, Gibson LF.
Leuk Res. 2013;37(5):483-484.

PMC4038928.

Impact of response to thalidomide-, lenalidomide- or bortezomib- containing induction therapy on the outcomes of multiple myeloma patients undergoing autologous transplantation.
Awan FT, Osman S, Kochuparambil ST, Gibson LF, Remick SC, Abraham J, Craig M, Jillella A, Hamadani M.
Bone Marrow Transplant. 2012;47(1):146-148.


Melphalan exposure induces an interleukin-6 deficit in bone marrow stromal cells and osteoblasts.
Rellick SL, Piktel D, Walton C, Hall B, Petros WP, Fortney JE, Gencheva M, Denvir J, Hobbs GR, Craig M, Gibson LF.
Cytokine. 2012;58(2):245-252.

PMC3319530.

Bone marrow osteoblast damage by chemotherapeutic agents.
Rellick SL, O'Leary HA, Piktel D, Walton C, Fortney JE, Akers SM, Martin KH, Denvir J, Boskovic G, Primerano DA, Vos JA, Bailey NG, Gencheva M, Gibson LF.
PLoS One. 2012;7(2):e30758

PMC3281873.

A smoking-associated 7-gene signature for lung cancer diagnosis and prognosis.
Wan YW, Raese RA, Fortney JE, Xiao C, Luo D, Cavendish J, Gibson LF, Castranova V, Qian Y, Guo NL.
Int J Oncol. 2012;41(4):1387-1396.

PMC3481011.

Cellular elements of the subarachnoid space promote ALL survival during chemotherapy.
Akers SM, Rellick SL, Fortney JE, Gibson LF.
Leuk Res. 2011;35(6):705-711.

PMC3099259.

Higher busulfan dose intensity does not improve outcomes of patients undergoing allogeneic haematopoietic cell transplantation following fludarabine, busulfan-based reduced toxicity conditioning.
Hamadani M, Craig M, Phillips GS, Abraham J, Tse WW, Cumpston AD, Gibson LF, Remick SC, Bunner P, Leadmon S, Elder P, Hofmeister C, Penza S, Efebera Y, Andritsos L, Garzon R, Benson DM, Blum W, Devine SM.
Hematol Oncol. 2011;29(4):202-210.

PMC3557914.

The evolving role of statins in hematopoietic stem and progenitor cell transplantation.
Hamadani M, Craig M, Gibson LF, Remick SC.
Am J Blood Res. 2011;1(1):57-64.

PMC3301410.

Higher infused CD34+ cell dose and overall survival in patients undergoing in vivo T-cell depleted, but not t-cell repleted, allogeneic peripheral blood hematopoietic cell transplantation.
Kanate AS, Craig M, Cumpston AD, Saad A, Hobbs GR, Leadmon S, Bunner P, Watkins K, Bulian D, Gibson LF, Abraham J, Remick SC, Hamadani M.
Hematol Oncol Stem Cell Ther. 2011;4(4):149-156.


Respiratory syncytial virus infection in human bone marrow stromal cells.
Rezaee F, Gibson LF, Piktel D, Othumpangat S, Piedimonte G.
Am J Respir Cell Mol Biol. 2011;45(2):277-286.

PMC3175557.

VE-cadherin and PECAM-1 enhance ALL migration across brain microvascular endothelial cell monolayers.
Akers SM, O'Leary HA, Minnear FL, Craig M, Vos JA, Coad JE, Gibson LF.
Exp Hematol. 2010;38(9):733-743.

PMC2929642.

VE-cadherin regulates Philadelphia chromosome positive acute lymphoblastic leukemia sensitivity to apoptosis.
O'Leary HA, Akers SM, Piktel D, Walton C, Fortney JE, Martin KH, Craig M, Coad JE, Gibson LF.
Cancer Microenviron. 2010;3(1):67-81.

PMC2990486.

Neurotrophins regulate bone marrow stromal cell IL-6 expression through the MAPK pathway.
Rezaee F, Rellick SL, Piedimonte G, Akers SM, O'Leary HA, Martin KH, Craig M, Gibson LF.
PLoS One. 2010;5(3):e9690

PMC2837737.

NGF is an essential survival factor for bronchial epithelial cells during respiratory syncytial virus infection.
Othumpangat S, Gibson LF, Samsell L, Piedimonte G.
PLoS One. 2009;4(7):e6444

PMC2715860.

Effect of morphine sulfate on neonatal neutrophil chemotaxis.
Yossuck P, Nightengale BJ, Fortney JE, Gibson LF.
Clin J Pain. 2008;24(1):76-82.


Ph+/VE-cadherin+ identifies a stem cell like population of acute lymphoblastic leukemia sustained by bone marrow niche cells.
Wang L, O'Leary HA, Fortney JE, Gibson LF.
Blood. 2007;110(9):3334-3344.

PMC2200915.

Chemotherapy disrupts activity of translational regulatory proteins in bone marrow stromal cells.
Clutter SD, Fortney JE, Gibson LF.
Exp Hematol. 2006;34(11):1522-1531.


MMP-2 is required for bone marrow stromal cell support of pro-B-cell chemotaxis.
Clutter SD, Fortney JE, Gibson LF.
Exp Hematol. 2005;33(10):1192-1200.

PMC1774816.

Activation of transforming growth factor-beta1/p38/Smad3 signaling in stromal cells requires reactive oxygen species-mediated MMP-2 activity during bone marrow damage.
Wang L, Clutter SD, Benincosa J, Fortney JE, Gibson LF.
Stem Cells. 2005;23(8):1122-1134.


VEGF-induced phosphorylation of Bcl-2 influences B lineage leukemic cell response to apoptotic stimuli.
Wang L, Chen L, Benincosa J, Fortney JE, Gibson LF.
Leukemia. 2005;19(3):344-353.


VEGF-induced survival of chronic lymphocytic leukemia is independent of Bcl-2 phosphorylation.
Wang L, Coad JE, Fortney JM, Gibson LF.
Leukemia. 2005;19(8):1486-1487.


Etoposide differentially affects bone marrow and dermal derived endothelial cells.
Adams SW, Wang L, Fortney JE, Gibson LF.
J Cell Mol Med. 2004;8(3):338-348.


Stromal cells expressing elevated VCAM-1 enhance survival of B lineage tumor cells.
Hall BM, Fortney JE, Taylor L, Wood H, Wang L, Adams SW, Davis S, Gibson LF.
Cancer Lett. 2004;207(2):229-239.


Regulation of lymphoid and myeloid leukemic cell survival: role of stromal cell adhesion molecules.
Hall BM, Gibson LF.
Leuk Lymphoma. 2004;45(1):35-48.


Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential.
Peister A, Mellad JA, Larson BL, Hall BM, Gibson LF, Prockop DJ.
Blood. 2004;103(5):1662-1668.


Stromal cell protection of B-lineage acute lymphoblastic leukemic cells during chemotherapy requires active Akt.
Wang L, Fortney JE, Gibson LF.
Leuk Res. 2004;28(7):733-742.


Regulation of eosinophilopoiesis in a murine model of asthma.
Hogan MB, Weissman DN, Hubbs AF, Gibson LF, Piktel D, Landreth KS.
J Immunol. 2003;171(5):2644-2651.


Chemotherapy induces bcl-2 cleavage in lymphoid leukemic cell lines.
Fortney JE, Hall BM, Bartrug L, Gibson LF.
Leuk Lymphoma. 2002;43(11):2171-2178.


Survival of B lineage leukemic cells: signals from the bone marrow microenvironment.
Gibson LF.
Leuk Lymphoma. 2002;43(1):19-27.


Bone marrow stromal cells regulate caspase 3 activity in leukemic cells during chemotherapy.
Fortney JE, Zhao W, Wenger SL, Gibson LF.
Leuk Res. 2001;25(10):901-907.


Propanil inhibits tumor necrosis factor-alpha production by reducing nuclear levels of the transcription factor nuclear factor-kappab in the macrophage cell line ic-21.
Frost LL, Neeley YX, Schafer R, Gibson LF, Barnett JB.
Toxicol Appl Pharmacol. 2001;172(3):186-193.


Alteration of nuclear factor-kappaB (NF-kappaB) expression in bone marrow stromal cells treated with etoposide.
Hall BM, Fortney JE, Gibson LF.
Biochem Pharmacol. 2001;61(10):1243-1252.


Hematopoiesis: the role of stromal integrin interactions in Pro-B cell proliferation.
Hahn BK, Piktel D, Gibson LF, Landreth KS.
Hematology. 2000;5(2):153-160.


Stromal cells regulate survival of B-lineage leukemic cells during chemotherapy.
Mudry RE, Fortney JE, York T, Hall BM, Gibson LF.
Blood. 2000;96(5):1926-1932.


Regulation of BAX and BCL-2 expression in breast cancer cells by chemotherapy.
Gibson LF, Fortney JE, Magro G, Ericson SG, Lynch JP, Landreth KS.
Breast Cancer Res Treat. 1999;55(2):107-117.


Interleukin-6 production by human neutrophils after Fc-receptor cross-linking or exposure to granulocyte colony-stimulating factor.
Ericson SG, Zhao Y, Gao H, Miller KL, Gibson LF, Lynch JP, Landreth KS.
Blood. 1998;91(6):2099-2107.


Disruption of bone marrow stromal cell function by etoposide.
Gibson LF, Fortney JE, Landreth KS, Piktel D, Ericson SG, Lynch JP.
Biol Blood Marrow Transplant. 1997;3(3):122-132.


Stromal cells regulate bcl-2 and bax expression in pro-B cells.
Gibson LF, Piktel D, Narayanan R, Nunez G, Landreth KS.
Exp Hematol. 1996;24(5):628-637.


Insulin-like growth factor-1 potentiates expansion of interleukin-7-dependent pro-B cells.
Gibson LF, Piktel D, Landreth KS.
Blood. 1993;82(10):3005-3011.