Publications of Lan Guo, PhD

mRNAs and miRNAs in whole blood associated with lung hyperplasia, fibrosis, and bronchiolo-alveolar adenoma and adenocarcinoma after multi-walled carbon nanotube inhalation exposure in mice.
Snyder-Talkington BN, Dong C, Sargent LM, Porter DW, Staska LM, Hubbs AF, Raese R, McKinney W, Chen BT, Battelli L, Lowry DT, Reynolds SH, Castranova V, Qian Y, Guo NL.
J Appl Toxicol. 2016;36(1):161-174.

PMC4418205.

mRNA and miRNA regulatory networks reflective of multi-walled carbon nanotube-induced lung inflammatory and fibrotic pathologies in mice.
Dymacek J, Snyder-Talkington BN, Porter DW, Mercer RR, Wolfarth MG, Castranova V, Qian Y, Guo NL.
Toxicol Sci. 2015;144(1):51-64.

PMC4349139.

Multi-walled carbon nanotube-induced gene expression in vitro: concordance with in vivo studies.
Snyder-Talkington BN, Dong C, Zhao X, Dymacek J, Porter DW, Wolfarth MG, Castranova V, Qian Y, Guo NL.
Toxicology. 2015;328:66-74.

PMC4308557.

Network-based identification of biomarkers coexpressed with multiple pathways.
Guo NL, Wan YW.
Cancer Inform. 2014;13(Suppl 5):37-47.

PMC4218687.

Integrated DNA Copy Number and Gene Expression Regulatory Network Analysis of Non-small Cell Lung Cancer Metastasis.
Iranmanesh SM, Guo NL.
Cancer Inform. 2014;13(Suppl 5):13-23.

PMC4218678.

Combining COPD with clinical, pathological and demographic information refines prognosis and treatment response prediction of non-small cell lung cancer.
Putila J, Guo NL.
PLoS One. 2014;9(6):e100994

PMC4072724.

The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells.
Pacurari M, Addison JB, Bondalapati N, Wan YW, Luo D, Qian Y, Castranova V, Ivanov AV, Guo NL.
Int J Oncol. 2013;43(2):548-560.

PMC3775564.

Systematic analysis of multiwalled carbon nanotube-induced cellular signaling and gene expression in human small airway epithelial cells.
Snyder-Talkington BN, Pacurari M, Dong C, Leonard SS, Schwegler-Berry D, Castranova V, Qian Y, Guo NL.
Toxicol Sci. 2013;133(1):79-89.

PMC3627550.

Multi-walled carbon nanotubes induce human microvascular endothelial cellular effects in an alveolar-capillary co-culture with small airway epithelial cells.
Snyder-Talkington BN, Schwegler-Berry D, Castranova V, Qian Y, Guo NL.
Part Fibre Toxicol. 2013;10:35

PMC3750368.

System-based identification of toxicity pathways associated with multi-walled carbon nanotube-induced pathological responses.
Snyder-Talkington BN, Dymacek J, Porter DW, Wolfarth MG, Mercer RR, Pacurari M, Denvir J, Castranova V, Qian Y, Guo NL.
Toxicol Appl Pharmacol. 2013;272(2):476-489.

PMC4017347.

Multiwalled carbon nanotube-induced gene signatures in the mouse lung: potential predictive value for human lung cancer risk and prognosis.
Guo NL, Wan YW, Denvir J, Porter DW, Pacurari M, Wolfarth MG, Castranova V, Qian Y.
J Toxicol Environ Health A. 2012;75(18):1129-1153.

PMC3422779.

Pathway-based identification of a smoking associated 6-gene signature predictive of lung cancer risk and survival.
Guo NL, Wan YW.
Artif Intell Med. 2012;55(2):97-105.

PMC3351561.

Cadmium increases HIF-1 and VEGF expression through ROS, ERK, and AKT signaling pathways and induces malignant transformation of human bronchial epithelial cells.
Jing Y, Liu LZ, Jiang Y, Zhu Y, Guo NL, Barnett JB, Rojanasakul Y, Agani FH, Jiang BH.
Toxicol Sci. 2012;125(1):10-19.

PMC3243743.

Multifunctional role of Bcl-2 in malignant transformation and tumorigenesis of Cr(VI)-transformed lung cells.
Medan D, Luanpitpong S, Azad N, Wang LY, Jiang BH, Davis ME, Barnett JB, Guo NL, Rojanasakul Y.
PLoS One. 2012;7(5):e37045

PMC3362580.

Cell permeability, migration, and reactive oxygen species induced by multiwalled carbon nanotubes in human microvascular endothelial cells.
Pacurari M, Qian Y, Fu W, Schwegler-Berry D, Ding M, Castranova V, Guo NL.
J Toxicol Environ Health A. 2012;75(2):112-128.

PMC3230883.

New perspectives for in vitro risk assessment of multiwalled carbon nanotubes: application of coculture and bioinformatics.
Snyder-Talkington BN, Qian Y, Castranova V, Guo NL.
J Toxicol Environ Health B Crit Rev. 2012;15(7):468-492.

PMC3513758.

A smoking-associated 7-gene signature for lung cancer diagnosis and prognosis.
Wan YW, Raese RA, Fortney JE, Xiao C, Luo D, Cavendish J, Gibson LF, Castranova V, Qian Y, Guo NL.
Int J Oncol. 2012;41(4):1387-1396.

PMC3481011.

Signaling pathway-based identification of extensive prognostic gene signatures for lung adenocarcinoma.
Wan YW, Beer DG, Guo NL.
Lung Cancer. 2012;76(1):98-105.

PMC3274212.

A novel network model identified a 13-gene lung cancer prognostic signature.
Guo NL, Wan YW, Bose S, Denvir J, Kashon ML, Andrew ME.
Int J Comput Biol Drug Des. 2011;4(1):19-39.

PMC3095973.

Multi-walled carbon nanotube-induced gene expression in the mouse lung: association with lung pathology.
Pacurari M, Qian Y, Porter DW, Wolfarth M, Wan Y, Luo D, Ding M, Castranova V, Guo NL.
Toxicol Appl Pharmacol. 2011;255(1):18-31.

PMC3148292.

Combining clinical, pathological, and demographic factors refines prognosis of lung cancer: a population-based study.
Putila JJ, Remick SC, Guo NL.
PLoS One. 2011;6(2):e17493

PMC3045456.

Association of arsenic exposure with lung cancer incidence rates in the United States.
Putila JJ, Guo NL.
PLoS One. 2011;6(10):e25886

PMC3189216.

The dual roles of c-Jun NH2-terminal kinase signaling in Cr(VI)-induced apoptosis in JB6 cells.
Son YO, Hitron JA, Cheng S, Budhraja A, Zhang Z, Guo NL, Lee JC, Shi X.
Toxicol Sci. 2011;119(2):335-345.

PMC3023565.

A 12-gene genomic instability signature predicts clinical outcomes in multiple cancer types.
Mettu RK, Wan YW, Habermann JK, Ried T, Guo NL.
Int J Biol Markers. 2010;25(4)

PMC3155635.

Perfluorooctane sulfonate (PFOS) induces reactive oxygen species (ROS) production in human microvascular endothelial cells: role in endothelial permeability.
Qian Y, Ducatman AM, Ward R, Leonard SS, Bukowski VC, Guo NL, Shi XL, Vallyathan V, Castranova V.
J Toxicol Environ Health A. 2010;73(12):819-836.

PMC3107001.

A population-based gene signature is predictive of breast cancer survival and chemoresponse.
Rathnagiriswaran S, Wan YW, Abraham J, Castranova V, Qian Y, Guo NL.
Int J Oncol. 2010;36(3):607-616.

PMC3103999.

A breast cancer prognostic signature predicts clinical outcomes in multiple tumor types.
Wan YW, Qian Y, Rathnagiriswaran S, Castranova V, Guo NL.
Oncol Rep. 2010;24(2):489-494.

PMC3095949.

Hybrid models identified a 12-gene signature for lung cancer prognosis and chemoresponse prediction.
Wan YW, Sabbagh E, Raese RA, Qian Y, Luo D, Denvir J, Vallyathan V, Castranova V, Guo NL.
PLoS One. 2010;5(8):e12222

PMC2923187.

Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling.
Apopa PL, Qian Y, Shao R, Guo NL, Schwegler-Berry D, Pacurari M, Porter DW, Shi XL, Vallyathan V, Castranova V, Flynn DC.
Part Fibre Toxicol. 2009;6:1

PMC2632982.

Impact and interactions between smoking and traditional prognostic factors in lung cancer progression.
Guo NL, Tosun K, Horn KA.
Lung Cancer. 2009;66(3):386-392.

PMC2783345.

The gene expression signature of genomic instability in breast cancer is an independent predictor of clinical outcome.
Habermann JK, Doering J, Hautaniemi S, Roblick UJ, Bundgen NK, Nicorici D, Kronenwett U, Rathnagiriswaran S, Mettu RK, Ma Y, Kruger S, Bruch HP, Auer G, Guo NL, Ried T.
Int J Cancer. 2009;124(7):1552-1564.

PMC2707256.

An integrative genomic and proteomic approach to chemosensitivity prediction.
Ma Y, Ding ZY, Qian Y, Wan YW, Tosun K, Shi XL, Castranova V, Harner EJ, Guo NL.
Int J Oncol. 2009;34(1):107-115.

PMC2667126.

Confirmation of gene expression-based prediction of survival in non-small cell lung cancer.
Guo NL, Wan YW, Tosun K, Lin H, Msiska Z, Flynn DC, Remick SC, Vallyathan V, Dowlati A, Shi XL, Castranova V, Beer DG, Qian Y.
Clin Cancer Res. 2008;14(24):8213-8220.

PMC2605664.

Oxidative stress and chromium(VI) carcinogenesis.
Yao H, Guo NL, Jiang BH, Luo J, Shi XL.
J Environ Pathol Toxicol Oncol. 2008;27(2):77-88.


Individualized survival and treatment response predictions for breast cancers using phospho-EGFR, phospho-ER, phospho-HER2/neu, phospho-IGF-IR/In, phospho-MAPK, and phospho-p70S6K proteins.
Guo NL, Abraham J, Flynn DC, Castranova V, Shi XL, Qian Y.
Int J Biol Markers. 2007;22(1):1-11.


Population-based molecular prognosis of breast cancer by transcriptional profiling.
Ma Y, Qian Y, Wei L, Abraham J, Shi XL, Castranova V, Harner EJ, Flynn DC, Guo NL.
Clin Cancer Res. 2007;13(7):2014-2022.


Constructing molecular classifiers for the accurate prognosis of lung adenocarcinoma.
Guo NL, Ma Y, Ward R, Castranova V, Shi XL, Qian Y.
Clin Cancer Res. 2006;12(11 Pt 1):3344-3354.


Predicting cancer drug response by proteomic profiling.
Ma Y, Ding Z, Qian Y, Shi XL, Castranova V, Harner EJ, Guo NL.
Clin Cancer Res. 2006;12(15):4583-4589.