Publications of Gregory W Konat, PhD

Peripheral challenge with a viral mimic upregulates expression of the complement genes in the hippocampus.
Michalovicz LT, Lally B, Konat GW.
J Neuroimmunol. 2015;285:137-142.

PMC Journal - In Process.

Analysis of extinction acquisition to attenuated tones in prenatally stressed and non-stressed offspring following auditory fear conditioning.
Salm AK, Lally BE, Borysiewicz E, Fil D, Konat GW.
Physiol Behav. 2015;139:157-166.


Peripherally restricted acute phase response to a viral mimic alters hippocampal gene expression.
Michalovicz LT, Konat GW.
Metab Brain Dis. 2014;29(1):75-86.

PMC4343041.

TLR3 ligation protects human astrocytes against oxidative stress.
Borysiewicz E, Doppalapudi S, Kirschman LT, Konat GW.
J Neuroimmunol. 2013;255(1-2):54-59.


A broad upregulation of cerebral chemokine genes by peripherally-generated inflammatory mediators.
Fil D, Borysiewicz E, Konat GW.
Metab Brain Dis. 2011;26(1):49-59.


Peripheral immune challenge with dsRNA enhances kainic acid-induced status epilepticus.
Kirschman LT, Borysiewicz E, Fil D, Konat GW.
Metab Brain Dis. 2011;26(1):91-93.


Peripheral immune challenge with viral mimic during early postnatal period robustly enhances anxiety-like behavior in young adult rats.
Konat GW, Lally BE, Toth AA, Salm AK.
Metab Brain Dis. 2011;26(3):237-240.


Dietary cholesterol impairs memory and memory increases brain cholesterol and sulfatide levels.
Darwish DS, Wang DS, Konat GW, Schreurs BG.
Behav Neurosci. 2010;124(1):115-123.

PMC3066467.

Effect of intensive lifestyle changes on endothelial function and on inflammatory markers of atherosclerosis.
Dod HS, Bhardwaj R, Sajja V, Weidner G, Hobbs GR, Konat GW, Manivannan S, Gharib W, Warden BE, Nanda NC, Beto RJ, Ornish D, Jain AC.
Am J Cardiol. 2010;105(3):362-367.


Phosphodiesterase 4B2 gene is an effector of Toll-like receptor signaling in astrocytes.
Borysiewicz E, Fil D, Dlaboga D, O'Donnell JM, Konat GW.
Metab Brain Dis. 2009;24(3):481-491.


Rho proteins are negative regulators of TLR2, TLR3, and TLR4 signaling in astrocytes.
Borysiewicz E, Fil D, Konat GW.
J Neurosci Res. 2009;87(7):1565-1572.


Peripheral challenge with double-stranded RNA elicits global up-regulation of cytokine gene expression in the brain.
Konat GW, Borysiewicz E, Fil D, James I.
J Neurosci Res. 2009;87(6):1381-1388.


Insulin enhances proliferation and viability of human umbilical vein endothelial cells.
Shrader CD, Bailey KM, Konat GW, Cilento EV, Reilly FD.
Arch Dermatol Res. 2009;301(2):159-166.


Cognitive dysfunction induced by chronic administration of common cancer chemotherapeutics in rats.
Konat GW, Kraszpulski M, James I, Zhang HT, Abraham J.
Metab Brain Dis. 2008;23(3):325-333.


Statins enhance toll-like receptor 4-mediated cytokine gene expression in astrocytes: implication of Rho proteins in negative feedback regulation.
Konat GW, Krasowska-Zoladek A, Kraszpulski M.
J Neurosci Res. 2008;86(3):603-609.


Dehydroalanine analog of glutathione: an electrophilic busulfan metabolite that binds to human glutathione S-transferase A1-1.
Younis IR, Elliott M, Peer CJ, Cooper AJ, Pinto JT, Konat GW, Kraszpulski M, Petros WP, Callery PS.
J Pharmacol Exp Ther. 2008;327(3):770-776.

PMC2678891.

Kinetics of inflammatory response of astrocytes induced by TLR 3 and TLR4 ligation.
Krasowska-Zoladek A, Banaszewska M, Kraszpulski M, Konat GW.
J Neurosci Res. 2007;85(1):205-212.


BRCA1 contributes to cell cycle arrest and chemoresistance in response to the anticancer agent irofulven.
Wiltshire T, Senft J, Wang Y, Konat GW, Wenger SL, Reed E, Wang W.
Mol Pharmacol. 2007;71(4):1051-1060.


Nucleotides induce higher order chromatin degradation.
Banaszewska M, Konat GW.
Mol Cell Biochem. 2006;282(1-2):39-43.


The role of Toll-like receptors in CNS response to microbial challenge.
Konat GW, Kielian T, Marriott I.
J Neurochem. 2006;99(1):1-12.

PMC2423668.

Epoxidation of the methamphetamine pyrolysis product, trans-phenylpropene, to trans-phenylpropylene oxide by CYP enzymes and stereoselective glutathione adduct formation.
Sanga M, Younis IR, Tirumalai PS, Bland TM, Banaszewska M, Konat GW, Tracy TS, Gannett PM, Callery PS.
Toxicol Appl Pharmacol. 2006;211(2):148-156.


Vulnerability of brain tissue to inflammatory oxidant, hypochlorous acid.
Krasowska A, Konat GW.
Brain Res. 2004;997(2):176-184.


Hydrogen peroxide mediates higher order chromatin degradation.
Bai H, Konat GW.
Neurochem Int. 2003;42(2):123-129.


Toxicity of compound A to C6 rat glioma cells.
Konat GW, Kofke WA, Miric SJ.
Metab Brain Dis. 2003;18(1):11-15.


H2O2-induced higher order chromatin degradation: a novel mechanism of oxidative genotoxicity.
Konat GW.
J Biosci. 2003;28(1):57-60.


Higher order chromatin degradation: implications for neurodegeneration.
Konat GW.
Neurochem Res. 2002;27(11):1447-1451.


Higher order chromatin degradation in glial cells: the role of calcium.
Konat GW, Mouzannar R, Bai H.
Neurochem Int. 2001;39(3):179-186.


Hydrogen peroxide induces transient dephosphorylation of tau protein in cultured rat oligodendrocytes.
LoPresti P, Konat GW.
Neurosci Lett. 2001;311(2):142-144.


Hydrogen peroxide induces rapid digestion of oligodendrocyte chromatin into high molecular weight fragments.
Mouzannar R, Miric SJ, Wiggins RC, Konat GW.
Neurochem Int. 2001;38(1):9-15.


Delayed oligodendrocyte degeneration induced by brief exposure to hydrogen peroxide.
Laszkiewicz I, Mouzannar R, Wiggins RC, Konat GW.
J Neurosci Res. 1999;55(3):303-310.


Antisense oligodeoxynucleotides targeted to MAG mRNA profoundly alter BP and PLP mRNA expression in differentiating oligodendrocytes: a caution.
Laszkiewicz I, Wiggins RC, Konat GW.
Metab Brain Dis. 1999;14(3):197-203.


Differentiation dependent activation of the myelin genes in purified oligodendrocytes is highly resistant to hypoglycemia.
Royland JE, Konat GW, Wiggins RC.
Metab Brain Dis. 1999;14(3):189-195.


Selenium is required for normal upregulation of myelin genes in differentiating oligodendrocytes.
Gu J, Royland JE, Wiggins RC, Konat GW.
J Neurosci Res. 1997;47(6):626-635.


Structural characterization of myelin-associated glycoprotein gene core promoter.
Laszkiewicz I, Grubinska B, Wiggins RC, Konat GW.
J Neurosci Res. 1997;50(6):928-936.


Generation of high efficiency ssDNA hybridization probes by linear polymerase chain reaction (LPCR).
Konat GW.
Scanning Microsc.Suppl. 1996;10:57-60.


Chromatin structure and transcriptional activity of MAG gene.
Konat GW.
Acta Neurobiol Exp (Wars). 1996;56(1):281-285.


Differentiation-specific demethylation of myelin associated glycoprotein gene in cultured oligodendrocytes.
Grubinska B, Laszkiewicz I, Royland JE, Wiggins RC, Konat GW.
J Neurosci Res. 1994;39(3):233-242.


Glioma-stimulated chemoattraction of endothelial cells and fibroblasts in vitro: a model for the study of glioma-induced angiogenesis.
Yassini PR, Stickler DL, Bloomfield SM, Wiggins RC, Konat GW.
Metab Brain Dis. 1994;9(4):391-399.


Transcriptional regulation of myelin associated glycoprotein gene expression by cyclic AMP.
Ye P, Laszkiewicz I, Wiggins RC, Konat GW.
J Neurosci Res. 1994;37(6):683-690.


Glucocorticoid-induced upregulation of proteolipid protein and myelin-associated glycoprotein genes in C6 cells.
Zhu W, Wiggins RC, Konat GW.
J Neurosci Res. 1994;37(2):208-212.


Cocaine cytotoxicity in serum-free environment: C6 glioma cell culture.
Gu J, Yassini PR, Goldberg G, Zhu W, Konat GW, Wiggins RC.
Neurotoxicology. 1993;14(1):19-22.


Myelin gene activation: a glucose sensitive critical period in development.
Royland JE, Konat GW, Wiggins RC.
J Neurosci Res. 1993;36(4):399-404.


Abnormal upregulation of myelin genes underlies the critical period of myelination in undernourished developing rat brain.
Royland JE, Konat GW, Wiggins RC.
Brain Res. 1993;607(1-2):113-116.


Spatiotemporal expression of SCIP and myelin genes in rat brain during early postnatal development.
Yassini PR, Wiggins RC, Konat GW.
Dev Neurosci. 1993;15(2):128-132.


Calcium-activated neutral proteinase (calpain) activity in C6 cell line: compartmentation of mu and m calpain.
Banik NL, Chakrabarti AK, Konat GW, Gantt-Wilford G, Hogan EL.
J Neurosci Res. 1992;31(4):708-714.


Differential upregulation of PLP and MAG genes in C6 glioma cells by N2A neuroblastoma conditioned medium.
Kanoh M, Wiggins RC, Konat GW.
Metab Brain Dis. 1992;7(3):147-156.


Ascorbic acid upregulates myelin gene expression in C6 glioma cells.
Laszkiewicz I, Wiggins RC, Konat GW.
Metab Brain Dis. 1992;7(3):157-164.


How much undernourishment is required to retard brain myelin development.
Royland JE, Klinkhachorn P, Konat GW, Wiggins RC.
Neurochem Int. 1992;21(2):269-274.


Down regulation of myelin-specific mRNAs in the mechanism of hypomyelination in the undernourished developing brain.
Royland JE, Konat GW, Kanoh M, Wiggins RC.
Brain Res Dev Brain Res. 1992;65(2):223-226.


Myelin isolation: comparison of sedimentation and flotation techniques.
Royland JE, Wiggins RC, Konat GW.
Neurochem Int. 1992;21(2):171-175.


Cyclic AMP-induced upregulation of proteolipid protein and myelin associated glycoprotein gene expression in C6 cells.
Ye P, Kanoh M, Zhu W, Laszkiewicz I, Royland JE, Wiggins RC, Konat GW.
J Neurosci Res. 1992;31(3):578-583.


Retinoic acid-regulated expression of proteolipid protein and myelin-associated glycoprotein genes in C6 glioma cells.
Zhu W, Kanoh M, Ye P, Laszkiewicz I, Royland JE, Wiggins RC, Konat GW.
J Neurosci Res. 1992;31(4):745-750.


Generation of high efficiency, single-stranded DNA hybridization probes by PCR.
Bednarczuk TA, Wiggins RC, Konat GW.
Biotechniques. 1991;10(4):478


Differential regulation of myelin gene expression in SV40 T antigen-transfected rat glioma C6 cells.
Bong M, Chakrabarti AK, Banik NL, Hogan EL, Kanoh M, Wiggins RC, Konat GW.
Metab Brain Dis. 1991;6(1):7-17.


Effect of culture conditions on PLP and MAG gene expression in rat glioma C6 cells.
Kanoh M, Ye P, Zhu W, Wiggins RC, Konat GW.
Metab Brain Dis. 1991;6(3):133-143.


Turbidity as a measure of particulate subcellular fraction yield.
Royland JE, Wiggins RC, Konat GW.
J Biochem Biophys Methods. 1991;23(2):131-134.


Rapid isolation of genomic DNA from animal tissues.
Konat GW, Gantt G, Laszkiewicz I, Hogan EL.
Exp Cell Res. 1990;190(2):294-296.


Human T lymphocyte response to myelin basic protein: selection of T lymphocyte lines from MBP-responsive donors.
Vandenbark AA, Chou YK, Bourdette D, Whitham R, Chilgren J, Chou CH, Konat GW, Hashim G, Vainiene M, Offner H.
J Neurosci Res. 1989;23(1):21-30.


Expression of myelin protein genes in quaking mouse brain.
Konat GW, Trojanowska M, Gantt G, Hogan EL.
J Neurosci Res. 1988;20(1):19-22.


Increased turnover of myelin proteolipid protein in quaking mouse brain.
Konat GW, Gantt G, Hogan EL.
Metab Brain Dis. 1987;2(2):113-116.


Peroxidative aggregation of myelin membrane proteins.
Konat GW, Gantt G, Gorman A, Wiggins RC.
Metab Brain Dis. 1986;1(3):177-185.


Myelin changes in the rats CNS following intraventricular injection of serum.
Konat GW, Diemer NH, Offner H.
Experientia. 1986;42(1):37-39.


Synthesis and acylation of myelin proteolipid protein in quaking mouse brain.
Konat GW, Gantt G, Singh I, Hogan EL.
Metab Brain Dis. 1986;1(4):241-247.


Chronic neurologic dysfunction and demyelination induced in Lewis rats by repeated injections of encephalitogenic T-lymphocyte lines.
Vandenbark AA, Nilaver G, Konat GW, Teal P, Offner H.
J Neurosci Res. 1986;16(4):643-656.


Intracellular translocation of myelin proteolipid protein.
Konat GW, Divakaran P, Samorajski T, Wiggins RC.
J Neurochem. 1985;44(5):1500-1510.


Effect of reactive oxygen species on myelin membrane proteins.
Konat GW, Wiggins RC.
J Neurochem. 1985;45(4):1113-1118.


Blood-brain and blood-spinal cord barrier permeability during the course of experimental allergic encephalomyelitis in the rat.
Juhler M, Barry DI, Offner H, Konat GW, Klinken L, Paulson OB.
Brain Res. 1984;302(2):347-355.


Triethyllead and cerebral development: an overview.
Konat GW.
Neurotoxicology. 1984;5(3):87-96.


Immunological expression of gangliosides in multiple sclerosis and in a demyelinating model disease in rabbits.
Sela BA, Offner H, Konat GW, Lev-Ram V, Cohen O, Cohen IR.
Adv Exp Med Biol. 1984;174:441-453.


The effect of serum from multiple sclerosis patients in remission on the incubated rat brain slices.
Konat GW, Offner H, Zeeberg I.
J Neurol Sci. 1983;60(3):363-366.


Abnofmalities in brain myelin or rabbits with experimental autoimmune multiple sclerosis-like disease induced by immunization to gangliosides.
Konat GW, Offner H, Lev-Ram V, Cohen O, Schwartz M, Cohen IR, Sela BA.
Acta Neurol Scand. 1982;66(5):568-574.


Effect of triethyllead on post-translational processing of myelin proteins.
Konat GW, Offner H.
Exp Neurol. 1982;75(1):89-94.


Elevated ganglioside concentration in serum and peripheral blood lymphocytes from multiple sclerosis patients in remission.
Sela BA, Konat GW, Offner H.
J Neurol Sci. 1982;54(1):143-148.


Intracellular translocation of newly synthesized myelin proteins in the rat brain stem slices.
Konat GW.
Exp Neurol. 1981;73(1):254-266.


Lymphocyte stimulation by gangliosides, cerebrosides and basic protein in juvenile rheumatoid arthritis.
Offner H, Pedersen FK, Konat GW.
J Clin Lab Immunol. 1981;6(1):35-37.


Multi-sialo brain gangliosides are powerful stimulators of active E-rosetting lymphocytes from multiple sclerosis patients.
Offner H, Konat GW, Sela BA.
J Neurol Sci. 1981;52(2-3):279-287.


Suppressive effect of triethyllead on entry of proteins into the CNS myelin sheath in vitro.
Konat GW, Clausen J.
J Neurochem. 1980;35(2):382-387.


Stimulation of active E-rosette forming lymphocytes from multiple sclerosis patients by gangliosides and cerebrosides.
Offner H, Konat GW.
J Neurol Sci. 1980;46(1):101-104.


Antigenic stimulation of active E-rosette-forming lymphocytes in multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis.
Offner H, Konat GW, Legg NJ, Raun NE, Winterberg H, Clausen J.
Clin Immunol Immunopathol. 1980;16(3):367-373.


The effect of triethyllead on total and myelin protein synthesis in rat forebrain slices.
Konat GW, Offner H, Clausen J.
J Neurochem. 1979;32(1):187-190.


Stimulation of active E-rosette forming lymphocytes by myelin basic protein and specific antigens from multiple sclerosis brains.
Offner H, Rastogi SC, Konat GW, Clausen J.
J Neurol Sci. 1979;42(3):349-355.


The enhancing effect of multiple sclerosis brain homogenates on the active E-rosette forming lymphocytes in neurological disorders.
Offner H, Fog T, Rastogi SC, Konat GW, Clausen J.
Acta Neurol Scand. 1979;59(2-3):49-54.


Partial purification of MS specific brain antigens.
Rastogi SC, Clausen J, Offner H, Konat GW, Fog T.
Acta Neurol Scand. 1979;59(6):281-296.


Protein composition of forebrain myelin isolated from triethyllead-intoxicated young rats.
Konat GW, Clausen J.
J Neurochem. 1978;30(4):907-909.


Effect of triethyllead on protein synthesis in rat forebrain.
Konat GW, Offner H, Clausen J.
Exp Neurol. 1978;59(1):162-167.


The enhancing effect of multiple sclerosis brain homogenates on the active E rosette forming lymphocytes.
Offner H, Rastogi SC, Konat GW, Calusen J.
J Neurol. 1978;218(4):245-251.


E rosette-forming lymphocytes in multiple sclerosis patients. Basic protein stimulation of rosette-forming cells.
Offner H, Konat GW, Raun NE, Clausen J.
Acta Neurol Scand. 1978;57(5):380-384.


Clinical, social and biochemical studies on Batten's syndrome, alias Spielmeyer-Vogot or Stengel's Syndrome.
Jensen GE, Clausen J, Melchior JC, Konat GW.
Eur Neurol. 1977;15(4):203-211.


Lymphocyte stimulation in multiple sclerosis patients untreated and treated with transfer factor. Long-term studies on the effect of different stimulants on myo-(2-3H)inositol incorporation into phosphatidylinositol of lymphocytes.
Offner H, Raun NE, Konat GW, Fog T, Clausen J.
Acta Neurol Scand. 1977;56(6):465-474.


A blood test for multiple sclerosis.
Offner H, Konat GW, Clausen J.
N Engl J Med. 1977;296(8):451-452.


Triethyllead-induced hypomyelination in the developing rat forebrain.
Konat GW, Clausen J.
Exp Neurol. 1976;50(1):124-133.


Triethyllead-restrained myelin deposition and protein synthesis in the developing rat forebrain.
Konat GW, Offner H, Clausen J.
Exp Neurol. 1976;52(1):58-65.


Morphological changes of astrocyte-like cells induced by serum beta-lipoprotein in brain cell culture.
Offner H, Konat GW, Clausen J.
Neurobiology. 1975;5(3):192-196.


The effect of methylmercury chloride and triethyllead chloride on sulphate incorporation into sulphatides of rat cerebellum slices during myelination.
Grundt I, Offner H, Konat GW, Clausen J.
Environ Physiol Biochem. 1974;4(4):166-171.


The effect of ?long-term administration of triethyl lead on the developing rat brain.
Konat GW, Clausen J.
Environ Physiol Biochem. 1974;4(5):236-242.


Effect of phytohemagglutinin, basic protein and measles antigen on myo-(2-3H)inositol incorporation into phosphatidylinositol of lymphocytes from patients with multiple sclerosis.
Offner H, Konat GW, Clausen J.
Acta Neurol Scand. 1974;50(6):791-800.


Endogenous microsomal phospholipid peroxidation in mouse brain.
Konat GW.
J Neurochem. 1973;20(4):1247-1256.


Enzymic and behavioural changes in mice fed polychlorinated biocides followed by starvation.
Clausen J, Konat GW.
Experientia. 1972;28(8):902-903.