Publications of Karen Martin, PhD

Bone marrow microenvironment modulation of acute lymphoblastic leukemia phenotype.
Moses BS, Slone WL, Thomas P, Evans R, Piktel D, Angel PM, Walsh CM, Cantrell PS, Rellick SL, Martin KH, Simpkins JW, Gibson LF.
Exp Hematol. 2016;44(1):50-59.


Three-dimensional microfluidic tri-culture model of the bone marrow microenvironment for study of acute lymphoblastic leukemia.
Bruce A, Evans R, Mezan R, Shi L, Moses BS, Martin KH, Gibson LF, Yang Y.
PLoS One. 2015;10(10):e0140506


High-fat, high-calorie diet enhances mammary carcinogenesis and local inflammation in MMTV-PyMT mouse model of breast cancer.
Cowen S, McLaughlin SL, Hobbs GR, Coad JE, Martin KH, Olfert IM, Vona-Davis LC.
Cancers (Basel). 2015;7(3):1125-1142.


SOX9 inhibits beta-TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties.
Deng W, Vanderbilt DB, Lin CC, Martin KH, Brundage KM, Ruppert JM.
J Cell Sci. 2015;128(6):1123-1138.


Modeling the bone marrow microenvironment's influence on leukemic disease.
Evans R, Martin KH, Moses BS, Slone WL, Hare I, Piktel D, Thomas P, Gibson LF.
Transl Biomed. 2015;6(2):14


PP2 Prevents isoproterenol stimulation of cardiac pacemaker activity.
Huang J, Lin YC, Hileman SM, Martin KH, Hull RA, Yu HG.
J Cardiovasc Pharmacol. 2015;65(2):193-202.


RepSox slows decay of CD34+ acute myeloid leukemia cells and decreasesT cell immunoglobulin mucin-3 expression.
Jajosky AN, Coad JE, Vos JA, Martin KH, Senft JR, Wenger SL, Gibson LF.
Stem Cells Transl Med. 2014;3(7):836-848.


Induction of stem-like cells with fibrogenic properties by carbon nanotubes and its role in fibrogenesis.
Luanpitpong S, Wang LY, Manke A, Castranova V, Yang Y, Martin KH, Ammer AG, Rojanasakul Y.
Nano Lett. 2014;14(6):3110-3116.


Ableson kinases negatively regulate invadopodia function and invasion in head and neck squamous cell carcinoma by inhibiting an HB-EGF autocrine loop.
Hayes KE, Walk EL, Ammer AG, Kelley LC, Martin KH, Weed SA.
Oncogene. 2013;32(40):4766-4777.


High-resolution vascular tissue characterization in mice using 55MHz ultrasound hybrid imaging.
Mahmoud AM, Sandoval C, Teng B, Schnermann JB, Martin KH, Mustafa SJ, Mukdadi OM.
Ultrasonics. 2013;53(3):727-738.


Metastatic MTLn3 and non-metastatic MTC adenocarcinoma cells can be differentiated by Pseudomonas aeruginosa.
Novotny MJ, Bridge DR, Martin KH, Weed SA, Wysolmerski RB, Olson JC.
Biol Open. 2013;2(9):891-900.


The group A streptococcal collagen-like protein-1, Scl1, mediates biofilm formation by targeting the extra domain A-containing variant of cellular fibronectin expressed in wounded tissue.
Oliver-Kozup H, Martin KH, Schwegler-Berry D, Green BJ, Betts C, Shinde AV, Van De Water L, Lukomski S.
Mol Microbiol. 2013;87(3):672-689.


Examining the role of actin-plasma membrane association in pseudomonas aeruginosa infection and type III secretion translocation in migratory T24 epithelial cells.
Bridge DR, Martin KH, Moore ER, Lee WM, Carroll JA, Rocha CL, Olson JC.
Infect Immun. 2012;80(9):3049-3064.


Src binds cortactin through a SH2 domain cystine-mediated linkage.
Evans JV, Ammer AG, Jett JE, Bolcato CA, Breaux JC, Martin KH, Culp M, Gannett PM, Weed SA.
J Cell Sci. 2012;125(Pt 24):6185-6197.


Quantitative measurement of invadopodia-mediated extracellular matrix proteolysis in single and multicellular contexts.
Martin KH, Hayes KE, Walk EL, Ammer AG, Markwell SM, Weed SA.
J Vis Exp. 2012;(66):4419


Bone marrow osteoblast damage by chemotherapeutic agents.
Rellick SL, O'Leary HA, Piktel D, Walton C, Fortney JE, Akers SM, Martin KH, Denvir J, Boskovic G, Primerano DA, Vos JA, Bailey NG, Gencheva M, Gibson LF.
PLoS One. 2012;7(2):e30758


Multi-photon imaging of tumor cell invasion in an orthotopic mouse model of oral squamous cell carcinoma.
Ammer AG, Hayes KE, Martin KH, Zhang L, Spirou GA, Weed SA.
J Vis Exp. 2011;(53)


Further insights into cortactin conformational regulation.
Evans JV, Kelley LC, Hayes KE, Ammer AG, Martin KH, Weed SA.
Bioarchitecture. 2011;1(1):21-23.


Revisiting the ERK/Src cortactin switch.
Kelley LC, Hayes KE, Ammer AG, Martin KH, Weed SA.
Commun Integr Biol. 2011;4(2):205-207.


The streptococcal collagen-like protein-1 (Scl1) is a significant determinant for biofilm formation by group a Streptococcus.
Oliver-Kozup HA, Elliott M, Bachert BA, Martin KH, Reid SD, Schwegler-Berry DE, Green BJ, Lukomski S.
BMC Microbiol. 2011;11:262


Quality assurance testing for modern optical imaging systems.
Stack RF, Bayles CJ, Girard AM, Martin KH, Opansky C, Schulz K, Cole RW.
Microsc Microanal. 2011;17(4):598-606.

The role of calcium release activated calcium channels in osteoclast differentiation.
Zhou Y, Lewis TL, Robinson LJ, Brundage KM, Schafer R, Martin KH, Blair HC, Soboloff J, Barnett JB.
J Cell Physiol. 2011;226(4):1082-1089.


Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation.
Kelley LC, Ammer AG, Hayes KE, Martin KH, Machida K, Jia L, Mayer BJ, Weed SA.
J Cell Sci. 2010;123(pt22):3923-3932.


Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence.
Kelley LC, Hayes KE, Ammer AG, Martin KH, Weed SA.
PLoS One. 2010;5(11):e13847


Inactivation of L-type calcium channel modulated by HCN2 channel.
Lin YC, Huang JY, Zhang Q, Hollander JM, Frisbee JC, Martin KH, Nestor C, Goodman R, Yu HG.
Am J Physiol Cell Physiol. 2010;298(5):C1029-C1037.


VE-cadherin regulates Philadelphia chromosome positive acute lymphoblastic leukemia sensitivity to apoptosis.
O'Leary HA, Akers SM, Piktel D, Walton C, Fortney JE, Martin KH, Craig M, Coad JE, Gibson LF.
Cancer Microenviron. 2010;3(1):67-81.


Neurotrophins regulate bone marrow stromal cell IL-6 expression through the MAPK pathway.
Rezaee F, Rellick SL, Piedimonte G, Akers SM, O'Leary HA, Martin KH, Craig M, Gibson LF.
PLoS One. 2010;5(3):e9690


Saracatinib impairs head and neck squamous cell carcinoma invasion by disrupting invadopodia function.
Ammer AG, Kelley LC, Hayes KE, Evans JV, Lopez-Skinner LA, Martin KH, Frederick B, Rothschild BL, Raben D, Elvin P, Green TP, Weed SA.
J Cancer Sci Ther. 2009;1(2):52-61.


A(1) adenosine receptor-mediated PKC and p42/p44 MAPK signaling in mouse coronary artery smooth muscle cells.
Ansari HR, Teng BY, Nadeem A, Roush KP, Martin KH, Schnermann JB, Mustafa SJ.
Am J Physiol Heart Circ Physiol. 2009;297(3):H1032-H1039.


FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts.
Iwanicki MP, Vomastek T, Tilghman RW, Martin KH, Banerjee J, Wedegaertner PB, Parsons JT.
J Cell Sci. 2008;121(Pt 6):895-905.

Disruption of FRNK expression by gene targeting of the intronic promoter within the focal adhesion kinase gene.
Hayasaka H, Martin KH, Hershey ED, Parsons JT.
J Cell Biochem. 2007;102(4):947-954.

Cellular characterization of a novel focal adhesion kinase inhibitor.
Slack-Davis JK, Martin KH, Tilghman RW, Iwanicki MP, Ung EJ, Autry C, Luzzio MJ, Cooper B, Kath JC, Roberts WG, Parsons JT.
J Biol Chem. 2007;282(20):14845-14852.

Cortactin phosphorylation sites mapped by mass spectrometry.
Martin KH, Jeffery ED, Grigera PR, Shabanowitz J, Hunt DF, Parsons JT.
J Cell Sci. 2006;119(Pt 14):2851-2853.

FAK phosphorylation sites mapped by mass spectrometry.
Grigera PR, Jeffery ED, Martin KH, Shabanowitz J, Hunt DF, Parsons JT.
J Cell Sci. 2005;118(Pt 21):4931-4935.

Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells.
Tilghman RW, Slack-Davis JK, Sergina N, Martin KH, Iwanicki MP, Hershey ED, Beggs HE, Reichardt LF, Parsons JT.
J Cell Sci. 2005;118(Pt 12):2613-2623.

The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly.
Liu Y, Loijens JC, Martin KH, Karginov AV, Parsons JT.
Mol Biol Cell. 2002;13(6):2147-2156.


Regulation of focal adhesion targeting and inhibitory functions of the FAK related protein FRNK using a novel estrogen receptor "switch".
Martin KH, Boerner SA, Parsons JT.
Cell Motil Cytoskeleton. 2002;51(2):76-88.

Integrin connections map: to infinity and beyond.
Martin KH, Slack JK, Boerner SA, Martin CC, Parsons JT.
Science. 2002;296(5573):1652-1653.

Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement.
Parsons JT, Martin KH, Slack JK, Taylor JM, Weed SA.
Oncogene. 2000;19(49):5606-5613.

Oocyte activation and passage through the metaphase/anaphase transition of the meiotic cell cycle is blocked in clams by inhibitors of HMG-CoA reductase activity.
Turner JE, Minkoff CG, Martin KH, Misra R, Swenson KI.
J Cell Biol. 1995;128(6):1145-1162.


Sp-1 binds promoter elements regulated by the RB protein and Sp-1-mediated transcription is stimulated by RB coexpression.
Udvadia AJ, Rogers KT, Higgins PD, Murata Y, Martin KH, Humphrey PA, Horowitz JM.
Proc Natl Acad Sci USA. 1993;90(8):3265-3269.