Publications of I. Mark Olfert, PhD

High-fat, high-calorie diet enhances mammary carcinogenesis and local inflammation in MMTV-PyMT mouse model of breast cancer.
Cowen S, McLaughlin SL, Hobbs GR, Coad JE, Martin KH, Olfert IM, Vona-Davis LC.
Cancers (Basel). 2015;7(3):1125-1142.


Improved arterial-ventricular coupling in metabolic syndrome after exercise training: a pilot study.
Fournier SB, Donley DA, Bonner DE, Devallance E, Olfert IM, Chantler PD.
Med Sci Sports Exerc. 2015;47(1):2-11.


Muscle-derived vascular endothelial growth factor regulates microvascular remodelling in response to increased shear stress in mice.
Uchida C, Nwadozi E, Hasanee A, Olenich S, Olfert IM, Haas TL.
Acta Physiol (Oxf). 2015;214(3):349-360.

Loss of adipocyte VEGF impairs endurance exercise capacity in mice.
Zachwieja NJ, O'Connell GC, Stricker JC, Allen J, Vona-Davis LC, Bryner R, Mandler W, Olfert IM.
Med Sci Sports Exerc. 2015;47(11):2329-2339.


Functional deficiencies of subsarcolemmal mitochondria in the type 2 diabetic human heart.
Croston TL, Thapa D, Holden AA, Tveter KJ, Lewis SE, Shepherd DL, Nichols CE, Long DM, Olfert IM, Jagannathan R, Hollander JM.
Am J Physiol Heart Circ Physiol. 2014;307(1):H54-H65.


Increase in relative deposition of fine particles in the rat lung periphery in the absence of gravity.
Darquenne C, Borja MG, Oakes JM, Breen EC, Olfert IM, Scadeng M, Prisk GK.
J Appl Physiol (1985). 2014;117(8):880-886.


Aerobic exercise training reduces arterial stiffness in metabolic syndrome.
Donley DA, Fournier SB, Reger BL, Devallance E, Bonner DE, Olfert IM, Frisbee JC, Chantler PD.
J Appl Physiol (1985). 2014;116(11):1396-1404.


Exercise reveals impairments in left ventricular systolic function in patients with metabolic syndrome.
Fournier SB, Reger BL, Donley DA, Bonner DE, Warden BE, Gharib W, Failinger CF, Olfert MD, Frisbee JC, Olfert IM, Chantler PD.
Exp Physiol. 2014;99(1):149-163.


Distinct temporal phases of microvascular rarefaction in skeletal muscle of obese Zucker rats.
Frisbee JC, Goodwill AG, Frisbee SJ, Butcher JT, Brock RW, Olfert IM, DeVallance ER, Chantler PD.
Am J Physiol Heart Circ Physiol. 2014;307(12):H1714-H1728.


Angiotensin II evokes angiogenic signals within skeletal muscle through co-ordinated effects on skeletal myocytes and endothelial cells.
Gorman JL, Liu ST, Slopack D, Shariati K, Hasanee A, Olenich S, Olfert IM, Haas TL.
PLoS One. 2014;9(1):e85537


Effects of detraining on the temporal expression of positive and negative angioregulatory proteins in skeletal muscle of mice.
Olenich SA, Audet GN, Roberts KA, Olfert IM.
J Physiol. 2014;592(Pt 15):3325-3338.


Inflammatory cytokine response to exercise in alpha-1-antitrypsin deficient COPD patients 'on' or 'off' augmentation therapy.
Olfert IM, Malek MH, Eagan TM, Wagner H, Wagner PD.
BMC Pulm.Med. 2014;14:106


Chronic delivery of a thrombospondin-1 mimetic decreases skeletal muscle capillarity in mice.
Audet GN, Fulks D, Stricker JC, Olfert IM.
PLoS One. 2013;8(2):e55953


Temporal response of positive and negative regulators in response to acute and chronic exercise training in mice.
Olenich SA, Gutierrez-Reed N, Audet GN, Olfert IM.
J Physiol. 2013;591(Pt 20):5157-5169.


Pulmonary gas exchange and acid-base balance during exercise.
Stickland MK, Lindinger MI, Olfert IM, Heigenhauser GJ, Hopkins SR.
Compr Physiol. 2013;3(2):693-739.

Expression of angiogenic regulators and skeletal muscle capillarity in selectively bred high aerobic capacity mice.
Audet GN, Meek TH, Garlandjr T, Olfert IM.
Exp Physiol. 2011;96(11):1138-1150.

Divergence between arterial perfusion and fatigue resistance in skeletal muscle in the metabolic syndrome.
Frisbee JC, Goodwill AG, Butcher JT, Olfert IM.
Exp Physiol. 2011;96(3):369-383.


Sildenafil and bosentan improve arterial oxygenation during acute hypoxic exercise: a controlled laboratory trial.
Olfert IM, Loeckinger A, Treml B, Faulhaber M, Flatz M, Burtscher M, Truebsbach S, Kleinsasser A.
Wilderness Environ Med. 2011;22(3):211-221.

Importance of anti-angiogenic factors in the regulation of skeletal muscle angiogenesis.
Olfert IM, Birot O.
Microcirculation. 2011;18(4):316-330.

Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise.
Philp A, Chen A, Lan D, Meyer GA, Murphy AN, Knapp AE, Olfert IM, McCurdy CE, Marcotte GR, Hogan MC, Baar K, Schenk S.
J Biol Chem. 2011;286(35):30561-30570.


Detraining losses of skeletal muscle capillarization are associated with vascular endothelial growth factor protein expression in rats.
Malek MH, Olfert IM, Esposito F.
Exp Physiol. 2010;95(2):359-368.

Myocyte vascular endothelial growth factor is required for exercise-induced skeletal muscle angiogenesis.
Olfert IM, Howlett RA, Wagner PD, Breen EC.
Am J Physiol Regul Integr Comp Physiol. 2010;299(4):R1059-R1067.


Rapid intravenous infusion of 20 ml/kg saline does not impair resting pulmonary gas exchange in the healthy human lung.
Prisk GK, Olfert IM, Arai TJ, Wagner PD, Hopkins SR.
J Appl Physiol. 2010;108(1):53-59.


Point: Exercise-induced intrapulmonary shunting is imaginary.
Hopkins SR, Olfert IM, Wagner PD.
J Appl Physiol. 2009;107(3):993-994.


Last word on point:counterpoint: Exercise-induced intrapulmonary shunting is imaginary vs. real.
Hopkins SR, Olfert IM, Wagner PD.
J Appl Physiol. 2009;107(3):1002


Global deletion of thrombospondin-1 increases cardiac and skeletal muscle capillarity and exercise capacity in mice.
Malek MH, Olfert IM.
Exp Physiol. 2009;94(6):749-760.

Muscle-specific VEGF deficiency greatly reduces exercise endurance in mice.
Olfert IM, Howlett RA, Tang K, Dalton ND, Gu Y, Peterson KL, Wagner PD, Breen EC.
J Physiol. 2009;587(Pt 8):1755-1767.


Skeletal muscle capillarity during hypoxia: VEGF and its activation.
Breen EC, Tang K, Olfert IM, Knapp A, Wagner PD.
High Alt Med Biol. 2008;9(2):158-166.

Arteriolar and venular capillary distribution in skeletal muscles of old rats.
Cui L, Ju Y, Ding L, Trejo-Morales M, Olfert IM.
J Gerontol A Biol Sci Med Sci. 2008;63(9):928-935.

The effect of incomplete acetylene washout on cardiac output measurement using open circuit acetylene uptake.
Balouch J, Olfert IM, Wagner PD, Hopkins SR.
Respir Physiol Neurobiol. 2007;155(2):177-183.

Effect of acetazolamide on pulmonary and muscle gas exchange during normoxic and hypoxic exercise.
Jonk AM, van den Berg I, Olfert IM, Wray DW, Arai TJ, Hopkins SR, Wagner PD.
J Physiol. 2007;579(Pt 3):909-921.


Tidal volume dependency of gas exchange in bronchoconstricted pig lungs.
Kleinsasser A, Olfert IM, Loeckinger A, Prisk GK, Hopkins SR, Wagner PD.
J Appl Physiol. 2007;103(1):148-155.

HIF-1alpha in endurance training: suppression of oxidative metabolism.
Mason SD, Rundqvist H, Papandreou I, Duh R, McNulty WJ, Howlett RA, Olfert IM, Sundberg CJ, Denko NC, Poellinger L, Johnson RS.
Am J Physiol Regul Integr Comp Physiol. 2007;293(5):R2059-R2069.

Steep head-down tilt has persisting effects on the distribution of pulmonary blood flow.
Henderson AC, Levin DL, Hopkins SR, Olfert IM, Buxton RB, Prisk GK.
J Appl Physiol. 2006;101(2):583-589.

Temporal thrombospondin-1 mRNA response in skeletal muscle exposed to acute and chronic exercise.
Olfert IM, Breen EC, Gavin TP, Wagner PD.
Growth Factors. 2006;24(4):253-259.

Muscle-targeted deletion of VEGF and exercise capacity in mice.
Wagner PD, Olfert IM, Tang K, Breen EC.
Respir Physiol Neurobiol. 2006;151(2-3):159-166.

Loss of skeletal muscle HIF-1alpha results in altered exercise endurance.
Mason SD, Howlett RA, Kim MJ, Olfert IM, Hogan MC, McNulty WJ, Hickey RP, Wagner PD, Kahn CR, Giordano FJ, Johnson RS.
PLoS Biol. 2004;2(10):e288


Does gender affect human pulmonary gas exchange during exercise?
Olfert IM, Balouch J, Kleinsasser A, Knapp A, Wagner H, Wagner PD, Hopkins SR.
J Physiol. 2004;557(Pt 2):529-541.


Oxygen consumption during maximal exercise in Fischer 344 x Brown Norway F1 hybrid rats.
Olfert IM, Balouch J, Mathieu-Costello O.
J Gerontol A Biol Sci Med Sci. 2004;59(8):801-808.

Effect of 60 degrees head-down tilt on peripheral gas mixing in the human lung.
Olfert IM, Prisk GK.
J Appl Physiol. 2004;97(3):827-834.

Skeletal muscle capillarity and angiogenic mRNA levels after exercise training in normoxia and chronic hypoxia.
Olfert IM, Breen EC, Mathieu-Costello O, Wagner PD.
J Appl Physiol. 2001;91(3):1176-1184.

Chronic hypoxia attenuates resting and exercise-induced VEGF, flt-1, and flk-1 mRNA levels in skeletal muscle.
Olfert IM, Breen EC, Mathieu-Costello O, Wagner PD.
J Appl Physiol. 2001;90(4):1532-1538.

Pulmonary gas exchange during exercise in women: effects of exercise type and work increment.
Hopkins SR, Barker RC, Brutsaert TD, Gavin TP, Entin PL, Olfert IM, Veisel S, Wagner PD.
J Appl Physiol. 2000;89(2):721-730.

Measurement of cardiac output during exercise by open-circuit acetylene uptake.
Barker RC, Hopkins SR, Kellogg N, Olfert IM, Brutsaert TD, Gavin TP, Entin PL, Rice AJ, Wagner PD.
J Appl Physiol. 1999;87(4):1506-1512.

Effect of prolonged, heavy exercise on pulmonary gas exchange in athletes.
Hopkins SR, Gavin TP, Siafakas NM, Haseler LJ, Olfert IM, Wagner H, Wagner PD.
J Appl Physiol. 1998;85(4):1523-1532.