Publications of Emidio Pistilli, PhD

IL-15Ralpha deficiency in skeletal muscle alters respiratory function and the proteome of mitochondrial subpopulations independent of changes to the mitochondrial genome.
O'Connell GC, Nichols C, Guo G, Croston TL, Thapa D, Hollander JM, Pistilli EE.
Mitochondrion. 2015;25:87-97.


Interleukin-15 directly stimulates pro-oxidative gene expression in skeletal muscle in-vitro via a mechanism that requires interleukin-15 receptor alpha.
O'Connell GC, Pistilli EE.
Biochem Biophys Res Commun. 2015;458(3):614-619.


Muscle-specific deletion of exons 2 and 3 of the IL15RA gene in mice: effects on contractile properties of fast and slow muscles.
O'Connell GC, Guo G, Stricker J, Quinn LS, Ma A, Pistilli EE.
J Appl Physiol (1985). 2015;118(4):437-448.


Resistance exercise training modulates acute gene expression during human skeletal muscle hypertrophy.
Nader GA, von WF, Liu C, Lindvall J, Gutmann L, Pistilli EE, Gordon PM.
J Appl Physiol (1985). 2014;116(6):693-702.


Aging alters contractile properties and fiber morphology in pigeon skeletal muscle.
Pistilli EE, Alway SE, Hollander JM, Wimsatt JH.
J Comp Physiol B. 2014;184(8):1031-1039.


Non-invasive serial casting to treat persistent toe walking in an 18 month old toddler.
Pistilli EE, Rice T, Pergami P, Mandich MB.
NeuroRehabilitation. 2014;34(2):215-220.


Non-invasive serial casting to treat idiopathic toe walking in an 18-month old child.
Pistilli EE, Rice T, Pergami P, Mandich MB.
NeuroRehabilitation. 2014;34(2):215-220.


FER-1/Dysferlin promotes cholinergic signaling at the neuromuscular junction in C. elegans and mice.
Krajacic P, Pistilli EE, Tanis JE, Khurana TS, Lamitina ST.
Biol Open. 2013;2(11):1245-1252.

PMC3828772.

Microarray analysis reveals novel features of the muscle aging process in men and women.
Liu D, Sartor MA, Nader GA, Pistilli EE, Tanton L, Lilly C, Gutmann L, IglayReger HB, Visich PS, Hoffman EP, Gordon PM.
J Gerontol A Biol Sci Med Sci. 2013;68(9):1035-1044.

PMC3826860.

IL-15Ralpha deficiency leads to mitochondrial and myofiber differences in fast mouse muscles.
Pistilli EE, Guo G, Stauber WT.
Cytokine. 2013;61(1):41-45.


From anabolic to oxidative: reconsidering the roles of IL-15 and IL-15Ralpha in skeletal muscle.
Pistilli EE, Quinn LS.
Exerc.Sport Sci Rev. 2013;41(2):100-106.


Resistance exercise training influences skeletal muscle immune activation: a microarray analysis.
Gordon PM, Liu D, Sartor MA, IglayReger HB, Pistilli EE, Gutmann L, Nader GA, Hoffman EP.
J Appl Physiol (1985). 2012;112(3):443-453.

PMC3289427.

IL-6 signaling blockade increases inflammation but does not affect muscle function in the mdx mouse.
Kostek MC, Nagaraju K, Pistilli EE, Sali A, Lai SH, Gordon B, Chen YW.
BMC Musculoskelet Disord. 2012;13:106

PMC3522537.

The role of TRAIL in mediating autophagy in myositis skeletal muscle: a potential nonimmune mechanism of muscle damage.
Alger HM, Raben N, Pistilli EE, Francia DL, Rawat R, Getnet D, Ghimbovschi S, Chen YW, Lundberg IE, Nagaraju K.
Arthritis Rheum. 2011;63(11):3448-3457.

PMC3203318.

Progression of volume load and muscular adaptation during resistance exercise.
Peterson MD, Pistilli EE, Haff GG, Hoffman EP, Gordon PM.
Eur J Appl Physiol. 2011;111(6):1063-1071.

PMC4215195.

Adiposity attenuates muscle quality and the adaptive response to resistance exercise in non-obese, healthy adults.
Peterson MD, Liu D, Gordish-Dressman H, Hubal MJ, Pistilli EE, Angelopoulos TJ, Clarkson PM, Moyna NM, Pescatello LS, Seip RL, Visich PS, Zoeller RF, Thompson PD, Devaney JM, Hoffman EP, Gordon PM.
Int J Obes (Lond). 2011;35(8):1095-1103.

PMC4147945.

Targeting the activin type IIB receptor to improve muscle mass and function in the mdx mouse model of Duchenne muscular dystrophy.
Pistilli EE, Bogdanovich S, Goncalves MD, Ahima RS, Lachey J, Seehra J, Khurana T.
Am J Pathol. 2011;178(3):1287-1297.

PMC3069867.

Loss of IL-15 receptor alpha alters the endurance, fatigability, and metabolic characteristics of mouse fast skeletal muscles.
Pistilli EE, Bogdanovich S, Garton F, Yang N, Gulbin JP, Conner JD, Anderson BG, Quinn LS, North K, Ahima RS, Khurana TS.
J Clin Invest. 2011;121(8):3120-3132.

PMC3148729.

Overexpression of interleukin-15 in mice promotes resistance to diet-induced obesity, increased insulin sensitivity, and markers of oxidative skeletal muscle metabolism.
Quinn LS, Anderson BG, Conner J, Pistilli EE, Wolden-Hanson T.
I J Interferon Cytokine and Mediator Research. 2011;2011(3):29-42.


Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition.
Goncalves MD, Pistilli EE, Balduzzi A, Birnbaum MJ, Lachey J, Khurana TS, Ahima RS.
PLoS One. 2010;5(9):e12707

PMC2939888.

Functional and molecular effects of arginine butyrate and prednisone on muscle and heart in the mdx mouse model of Duchenne Muscular Dystrophy.
Guerron AD, Rawat R, Sali A, Spurney CF, Pistilli EE, Cha HJ, Pandey GS, Gernapudi R, Francia D, Farajian V, Escolar DM, Bossi L, Becker M, Zerr P, de la PS, Gordish-Dressman H, Partridge T, Hoffman EP, Nagaraju K.
PLoS One. 2010;5(6):e11220

PMC2888587.

Skeletal muscle gene expression in response to resistance exercise: sex specific regulation.
Liu D, Sartor MA, Nader GA, Gutmann L, Treutelaar MK, Pistilli EE, IglayReger HB, Burant CF, Hoffman EP, Gordon PM.
BMC Genomics. 2010;11:659

PMC3091777.

Pretreatment with a soluble activin type IIB receptor/Fc fusion protein improves hypoxia-induced muscle dysfunction.
Pistilli EE, Bogdanovich S, Mosqueira M, Lachey J, Seehra J, Khurana TS.
Am J Physiol Regul Integr Comp Physiol. 2010;298(1):R96-R103.

PMC2806202.

Evaluation of skeletal and cardiac muscle function after chronic administration of thymosin beta-4 in the dystrophin deficient mouse.
Spurney CF, Cha HJ, Sali A, Pandey GS, Pistilli EE, Guerron AD, Gordish-Dressman H, Hoffman EP, Nagaraju K.
PLoS One. 2010;5(1):e8976

PMC2813286.

The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity.
Akpan I, Goncalves MD, Dhir R, Yin X, Pistilli EE, Bogdanovich S, Khurana TS, Ucran J, Lachey J, Ahima RS.
Int J Obes (Lond). 2009;33(11):1265-1273.

PMC2783781.

Preclinical drug trials in the mdx mouse: assessment of reliable and sensitive outcome measures.
Spurney CF, Gordish-Dressman H, Guerron AD, Sali A, Pandey GS, Rawat R, Van Der Meulen JH, Cha HJ, Pistilli EE, Partridge TA, Hoffman EP, Nagaraju K.
Muscle Nerve. 2009;39(5):591-602.

PMC4116326.

Systemic elevation of interleukin-15 in vivo promotes apoptosis in skeletal muscles of young adult and aged rats.
Pistilli EE, Alway SE.
Biochem Biophys Res Commun. 2008;373(1):20-24.

PMC2569888.

Interleukin-15 and interleukin-15R alpha SNPs and associations with muscle, bone, and predictors of the metabolic syndrome.
Pistilli EE, Devaney JM, Gordish-Dressman H, Bradbury MK, Seip RL, Thompson PD, Angelopoulos TJ, Clarkson PM, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Gordon PM, Hoffman EP.
Cytokine. 2008;43(1):45-53.

PMC2593832.

Age-dependent increase in oxidative stress in gastrocnemius muscle with unloading.
Siu PM, Pistilli EE, Alway SE.
J Appl Physiol. 2008;105(6):1695-1705.

PMC2612472.

Dystrophin-deficient cardiomyopathy in mouse: expression of Nox4 and Lox are associated with fibrosis and altered functional parameters in the heart.
Spurney CF, Knoblach S, Pistilli EE, Nagaraju K, Martin GR, Hoffman EP.
Neuromuscul Disord. 2008;18(5):371-381.

PMC2430663.

Interleukin-15 responses to aging and unloading-induced skeletal muscle atrophy.
Pistilli EE, Siu PM, Alway SE.
Am J Physiol Cell Physiol. 2007;292(4):C1298-C1304.


Resistin polymorphisms are associated with muscle, bone, and fat phenotypes in white men and women.
Pistilli EE, Gordish-Dressman H, Seip RL, Devaney JM, Thompson PD, Price TB, Angelopoulos TJ, Clarkson PM, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Hoffman EP, Gordon PM.
Obesity (Silver Spring). 2007;15(2):392-402.


Potential of oligonucleotide-mediated exon-skipping therapy for Duchenne muscular dystrophy.
Yokota T, Pistilli EE, Duddy W, Nagaraju K.
Expert Opin Biol Ther. 2007;7(6):831-842.


Peak force and rate of force development during isometric and dynamic mid-thigh clean pulls performed at various intensities.
Kawamori N, Rossi SJ, Justice BD, Haff EE, Pistilli EE, O'Bryant HS, Stone MH, Haff GG.
J Strength Cond Res. 2006;20(3):483-491.


Molecular regulation of apoptosis in fast plantaris muscles of aged rats.
Pistilli EE, Siu PM, Alway SE.
J Gerontol A Biol Sci Med Sci. 2006;61(3):245-255.

PMC2778222.

Death receptor-associated pro-apoptotic signaling in aged skeletal muscle.
Pistilli EE, Jackson JR, Alway SE.
Apoptosis. 2006;11(12):2115-2126.


Hindlimb unloading increases muscle content of cytosolic but not nuclear Id2 and p53 proteins in young adult and aged rats.
Siu PM, Pistilli EE, Murlasits Z, Alway SE.
J Appl Physiol. 2006;100(3):907-916.


Nondisease genetic testing: reporting of muscle SNPs shows effects on self-concept and health orientation scales.
Gordon ES, Gordish-Dressman HA, Devaney J, Clarkson P, Thompson P, Gordon P, Pescatello LS, Hubal MJ, Pistilli EE, Gianetti G, Kelsey B, Hoffman EP.
Eur J Hum Genet. 2005;13(9):1047-1054.


Aging sustains the hypertrophy-associated elevation of apoptotic suppressor X-linked inhibitor of apoptosis protein (XIAP) in skeletal muscle during unloading.
Siu PM, Pistilli EE, Ryan MJ, Alway SE.
J Gerontol A Biol Sci Med Sci. 2005;60(8):976-983.


Aging influences cellular and molecular responses of apoptosis to skeletal muscle unloading.
Siu PM, Pistilli EE, Butler DC, Alway SE.
Am J Physiol Cell Physiol. 2005;288(2):C338-C349.


Apoptotic responses to hindlimb suspension in gastrocnemius muscles from young adult and aged rats.
Siu PM, Pistilli EE, Alway SE.
Am J Physiol Regul Integr Comp Physiol. 2005;289(4):R1015-R1026.


Influence of carbohydrate and age on lymphocyte function following a marathon.
Henson DA, Nieman DC, Pistilli EE, Schilling B, Colacino A, Utter AC, Fagoaga OR, Vinci DM, Nehlsen-Cannarella SL.
Int J Sport Nutr Exerc Metab. 2004;14(3):308-322.


The effects of 8 weeks of creatine monohydrate and glutamine supplementation on body composition and performance measures.
Lehmkuhl M, Malone M, Justice B, Trone G, Pistilli EE, Vinci DM, Haff EE, Kilgore JL, Haff GG.
J Strength Cond Res. 2003;17(3):425-438.