Publications of Heimo Riedel, PhD

Rescue of DNA-PK signaling and T-Cell differentiation by targeted genome editing in a prkdc deficient iPSC disease model.
Rahman SH, Kuehle J, Reimann C, Mlambo T, Alzubi J, Maeder ML, Riedel H, Fisch P, Cantz T, Rudolph C, Mussolino C, Joung JK, Schambach A, Cathomen T.
PLoS Genet. 2015;11(5):e1005239


PSP94, an upstream signaling mediator of prostasin found highly elevated in ovarian cancer.
Ma JX, Yan BX, Zhang J, Jiang BH, Guo Y, Riedel H, Mueller MD, Remick SC, Yu JJ.
Cell Death Dis. 2014;5:e1407

PMC Journal – In Process.

PSP94 contributes to chemoresistance and its peptide derivative PCK3145 represses tumor growth in ovarian cancer.
Yan BX, Ma JX, Zhang J, Guo Y, Riedel H, Mueller MD, Remick SC, Yu JJ.
Oncogene. 2014;33(45):5288-5294.

Insulin receptor kinase-independent signaling via tyrosine phosphorylation of phosphatase PHLPP1.
Zhang MC, Riedel H.
J Cell Biochem. 2009;107(1):65-75.

Mitogenic roles of Gab1 and Grb10 as direct cellular partners in the regulation of MAP kinase signaling.
Deng Y, Zhang M, Riedel H.
J Cell Biochem. 2008;105(5):1172-1182.

PSM/SH2B1 splice variants: critical role in src catalytic activation and the resulting STAT3s-mediated mitogenic response.
Zhang MC, Deng YP, Riedel H.
J Cell Biochem. 2008;104(1):105-118.

Essential role of PSM/SH2-B variants in insulin receptor catalytic activation and the resulting cellular responses.
Zhang MC, Deng YP, Tandon R, Bai C, Riedel H.
J Cell Biochem. 2008;103(1):162-181.

PSM/SH2-B distributes selected mitogenic receptor signals to distinct components in the PI3-kinase and MAP kinase signaling pathways.
Deng Y, Xu H, Riedel H.
J Cell Biochem. 2007;100(3):557-573.

Grb10: more than a simple adaptor protein.
Lim MA, Riedel H, Liu F.
Front Biosci. 2004;9:387-403.

Grb10 exceeding the boundaries of a common signaling adapter.
Riedel H.
Front Biosci. 2004;9:603-618.

Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action.
Deng Y, Bhattacharya S, Swamy OR, Tandon R, Wang Y, Janda R, Riedel H.
J Biol Chem. 2003;278(41):39311-39322.

Inhibition of protein kinase C catalytic activity by additional regions within the human protein kinase Calpha-regulatory domain lying outside of the pseudosubstrate sequence.
Kirwan AF, Bibby AC, Mvilongo T, Riedel H, Burke T, Millis SZ, Parissenti AM.
Biochem J. 2003;373(Pt 2):571-581.


Yeast as a host to screen for modulators and regulatory regions of mammalian protein kinase C isoforms.
Parissenti AM, Riedel H.
Methods Mol Biol. 2003;233:491-516.

Four PSM/SH2-B alternative splice variants and their differential roles in mitogenesis.
Yousaf N, Deng Y, Kang Y, Riedel H.
J Biol Chem. 2001;276(44):40940-40948.

PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis.
Riedel H, Yousaf N, Zhao Y, Dai H, Deng Y, Wang J.
Oncogene. 2000;19(1):39-50.

Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis.
Wang J, Dai H, Yousaf N, Moussaif M, Deng Y, Boufelliga A, Swamy OR, Leone ME, Riedel H.
Mol Cell Biol. 1999;19(9):6217-6228.


IRS pleckstrin homology domains bind to acidic motifs in proteins.
Burks DJ, Wang J, Towery H, Ishibashi O, Lowe D, Riedel H, White MF.
J Biol Chem. 1998;273(47):31061-31067.

Deletion analysis of protein kinase Calpha reveals a novel regulatory segment.
Rotenberg SA, Zhu J, Hansen H, Li XD, Sun XG, Michels CA, Riedel H.
J Biochem. 1998;124(4):756-763.

Modulation of rat rotational behavior by direct gene transfer of constitutively active protein kinase C into nigrostriatal neurons.
Song S, Wang Y, Bak SY, During MJ, Bryan J, Ashe O, Ullrey DB, Trask LE, Grant FD, O'Malley KL, Riedel H, Goldstein DS, Neve KA, LaHoste GJ, Marshall JF, Haycock JW, Neve RL, Geller AI.
J Neurosci. 1998;18(11):4119-4132.

Insulin-like growth factor-I receptor and insulin receptor association with a Src homology-2 domain-containing putative adapter.
Wang J, Riedel H.
J Biol Chem. 1998;273(6):3136-3139.

The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts.
Laviola L, Giorgino F, Chow JC, Baquero JA, Hansen H, Ooi J, Zhu J, Riedel H, Smith RJ.
J Clin Invest. 1997;99(5):830-837.


PSM, an insulin-dependent, pro-rich, PH, SH2 domain containing partner of the insulin receptor.
Riedel H, Wang J, Hansen H, Yousaf N.
J Biochem. 1997;122(6):1105-1113.

Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus.
Hansen H, Svensson U, Zhu J, Laviola L, Giorgino F, Wolf G, Smith RJ, Riedel H.
J Biol Chem. 1996;271(15):8882-8886.

Activation of conventional mammalian protein kinase C isoforms expressed in budding yeast modulates the cell doubling time--a potential in vivo screen for protein kinase C activators.
Shieh HL, Hansen H, Zhu J, Riedel H.
Cancer Detect Prev. 1996;20(6):576-589.

Deletion analysis of protein kinase C inactivation by calphostin C.
Rotenberg SA, Huang MH, Zhu J, Su L, Riedel H.
Mol Carcinog. 1995;12(1):42-49.

Differential protein kinase C ligand regulation detected in vivo by a phenotypic yeast assay.
Shieh HL, Hansen H, Zhu J, Riedel H.
Mol Carcinog. 1995;12(3):166-176.

Epidermal growth factor (EGF) modulation of feline sarcoma virus fms tyrosine kinase activity, internalization, degradation, and transforming potential in an EGF receptor/v-fms chimera.
Riedel H.
J Virol. 1994;68(1):411-424.


Ligand regulation of bovine protein kinase C alpha response via either cysteine-rich repeat of conserved region C1.
Zhu J, Hansen H, Su L, Shieh HL, Riedel H.
J Biochem. 1994;115(5):1000-1009.

Reconstitution of protein kinase C alpha function by the protein kinase C beta-I carboxy terminus.
Parissenti AM, Su L, Riedel H.
Mol Cell Endocrinol. 1993;98(1):9-16.

Stimulation of calcium uptake in Saccharomyces cerevisiae by bovine protein kinase C alpha.
Riedel H, Parissenti AM, Hansen H, Su L, Shieh HL.
J Biol Chem. 1993;268(5):3456-3462.

Yeast phenotype classifies mammalian protein kinase C cDNA mutants.
Riedel H, Su L, Hansen H.
Mol Cell Biol. 1993;13(8):4728-4735.


Phorbol ester activation of functional rat protein kinase C beta-1 causes phenotype in yeast.
Riedel H, Hansen H, Parissenti AM, Su L, Shieh HL, Zhu J.
J Cell Biochem. 1993;52(3):320-329.

Functional carboxyl terminal deletion map of protein kinase C alpha.
Su L, Parissenti AM, Riedel H.
Receptors Channels. 1993;1(1):1-9.

Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors.
Riedel H, Dull TJ, Honegger AM, Schlessinger J, Ullrich A.
EMBO J. 1989;8(10):2943-2954.


Ligand activation of overexpressed epidermal growth factor receptors transforms NIH 3T3 mouse fibroblasts.
Riedel H, Massoglia S, Schlessinger J, Ullrich A.
Proc Natl Acad Sci USA. 1988;85(5):1477-1481.


A chimeric, ligand-binding v-erbB/EGF receptor retains transforming potential.
Riedel H, Schlessinger J, Ullrich A.
Science. 1987;236(4798):197-200.

A chimaeric receptor allows insulin to stimulate tyrosine kinase activity of epidermal growth factor receptor.
Riedel H, Dull TJ, Schlessinger J, Ullrich A.
Nature. 1986;324(6092):68-70.

Protein kinases in cellular signal transduction: tyrosine kinase growth factor receptors and protein kinase C.
Ullrich A, Riedel H, Yarden Y, Coussens L, Gray A, Dull TJ, Schlessinger J, Waterfield MD, Parker PJ.
Cold Spring Harb Symp Quant Biol. 1986;51 Pt 2:713-724.

Different membrane anchors allow the Semliki Forest virus spike subunit E2 to reach the cell surface.
Riedel H.
J Virol. 1985;54(1):224-228.


Cell surface expression of fusogenic vesicular stomatitis virus G protein from cloned cDNA.
Riedel H, Kondor-Koch C, Garoff H.
EMBO J. 1984;3(7):1477-1483.


Expression of viral membrane proteins from cloned cDNA by microinjection into eukaryotic cell nuclei.
Timm B, Kondor-Koch C, Lehrach H, Riedel H, Edstrom JE, Garoff H.
Methods Enzymol. 1983;96:496-511.

A procedure to verify an amino acid sequence which has been derived from a nucleotide sequence: application to the 26S RNA of Semliki Forest virus.
Garoff H, Riedel H, Lehrach H.
Nucleic Acids Res. 1982;10(2):675-687.


Structure and assembly of alphaviruses.
Garoff H, Kondor-Koch C, Riedel H.
Curr Top Microbiol Immunol. 1982;99:1-50.

Expression of the structural proteins of Semliki Forest virus from cloned cDNA microinjected into the nucleus of baby hamster kidney cells.
Kondor-Koch C, Riedel H, Soderberg K, Garoff H.
Proc Natl Acad Sci USA. 1982;79(15):4525-4529.


Nucleotide sequence at the junction between the nonstructural and the structural genes of the semliki forest virus genome.
Riedel H, Lehrach H, Garoff H.
J Virol. 1982;42(2):725-729.