Publications of Charles Rosen, MD, PhD

Quality of life and obstructive sleep apnea symptoms after pediatric adenotonsillectomy.
Garetz SL, Mitchell RB, Parker PD, Moore RH, Rosen CL, Giordani B, Muzumdar H, Paruthi S, Elden L, Willging P, Beebe DW, Marcus CL, Chervin RD, Redline S.
Pediatrics. 2015;135(2):e477-e486.


Complications of adenotonsillectomy for obstructive sleep apnea in school-aged children.
Konstantinopoulou S, Gallagher P, Elden L, Garetz SL, Mitchell RB, Redline S, Rosen CL, Katz ES, Chervin RD, Amin R, Arens R, Paruthi S, Marcus CL.
Int J Pediatr Otorhinolaryngol. 2015;79(2):240-245.


Role of microvascular disruption in brain damage from traumatic brain injury.
Logsdon AF, Lucke-Wold BP, Turner RC, Huber JD, Rosen CL, Simpkins JW.
Compr Physiol. 2015;5(3):1147-1160.


Bryostatin-1 restores blood brain barrier integrity following blast-induced traumatic brain injury.
Lucke-Wold BP, Logsdon AF, Smith KE, Turner RC, Alkon DL, Tan Z, Naser ZJ, Knotts CM, Huber JD, Rosen CL.
Mol Neurobiol. 2015;52(3):1119-1134.

Common mechanisms of Alzheimer's disease and ischemic stroke: the role of protein kinase C in the progression of age-related neurodegeneration.
Lucke-Wold BP, Turner RC, Logsdon AF, Simpkins JW, Alkon DL, Smith KE, Chen YW, Tan Z, Huber JD, Rosen CL.
J Alzheimers Dis. 2015;43(3):711-724.


Sleep disruption and the sequelae associated with traumatic brain injury.
Lucke-Wold BP, Smith KE, Nguyen L, Turner RC, Logsdon AF, Jackson GJ, Huber JD, Rosen CL, Miller DB.
Neurosci Biobehav Rev. 2015;55:68-77.

Traumatic brain injury and epilepsy: underlying mechanisms leading to seizure.
Lucke-Wold BP, Nguyen L, Turner RC, Logsdon AF, Chen YW, Smith KE, Huber JD, Matsumoto R, Rosen CL, Tucker ES, Richter E.
Seizure. 2015;33:13-23.

Amelioration of nicotinamide adenine dinucleotide phosphate-oxidase mediated stress reduces cell death after blast-induced traumatic brain injury.
Lucke-Wold BP, Naser ZJ, Logsdon AF, Turner RC, Smith KE, Robson MJ, Bailes JE, Lee JM, Rosen CL, Huber JD.
Transl Res. 2015;166(6):509-528.

Bryostatin extends tPA time window to 6h following middle cerebral artery occlusion in aged female rats.
Tan Z, Lucke-Wold BP, Logsdon AF, Turner RC, Tan C, Li X, Hongpaison J, Alkon DL, Simpkins JW, Rosen CL, Huber JD.
Eur J Pharmacol. 2015;764:404-412.


Modeling chronic traumatic encephalopathy: the way forward for future discovery.
Turner RC, Lucke-Wold BP, Logsdon AF, Robson MJ, Lee JM, Bailes JE, Dashnaw ML, Huber JD, Petraglia AL, Rosen CL.
Front Neurol. 2015;6:223


The quest to model chronic traumatic encephalopathy: a multiple model and injury paradigm experience.
Turner RC, Lucke-Wold BP, Logsdon AF, Robson MJ, Dashnaw ML, Huang JH, Smith KE, Huber JD, Rosen CL, Petraglia AL.
Front Neurol. 2015;6:222


Transcranial orbital decompression for progressive compressive optic neuropathy after 3-wall decompression in severe graves' orbitopathy.
Bingham CM, Harris MA, Vidor IA, Rosen CL, Linberg JV, Marentette LJ, Elner VM, Sivak-Callcott JA.
Ophthal.Plast.Reconstr.Surg. 2014;30(3):215-218.

A review of sleep deprivation studies evaluating the brain transcriptome.
Elliott AS, Huber JD, O'Callaghan JP, Rosen CL, Miller DB.
Springerplus. 2014;3:728


Altering endoplasmic reticulum stress in a model of blast-induced traumatic brain injury controls cellular fate and ameliorates neuropsychiatric symptoms.
Logsdon AF, Turner RC, Lucke-Wold BP, Robson MJ, Naser ZJ, Smith KE, Matsumoto RR, Huber JD, Rosen CL.
Front Cell Neurosci. 2014;8:421


Linking traumatic brain injury to chronic traumatic encephalopathy: identification of potential mechanisms leading to neurofibrillary tangle development.
Lucke-Wold BP, Turner RC, Logsdon AF, Bailes JE, Huber JD, Rosen CL.
J Neurotrauma. 2014;31(13):1129-1138.


Ischemic stroke injury is mediated by aberrant Cdk5.
Meyer DA, Torres-Altoro MI, Tan Z, Tozzi A, Di FM, DiNapoli V, Plattner F, Kansy JW, Benkovic SA, Huber JD, Miller DB, Greengard P, Calabresi P, Rosen CL, Bibb JA.
J Neurosci. 2014;34(24):8259-8267.


Role of GPI anchored proteins in neural cell adhesion.
Struky AF, Rosen CL, Salzer JL.
Advances Molecular Cell Biology. 2014;16:193-222.

Combination treatment of r-tPA and an optimized human apyrase reduces mortality rate and hemorrhagic transformation 6h after ischemic stroke in aged female rats.
Tan Z, Li X, Turner RC, Logsdon AF, Lucke-Wold B, DiPasquale K, Soeg JS, Chen R, Huber JD, Rosen CL.
Eur J Pharmacol. 2014;738:368-373.

Elucidating the severity of preclinical traumatic brain injury models: a role for functional assessment?
Turner RC, VanGilder RL, Naser ZJ, Lucke-Wold BP, Bailes JE, Matsumoto RR, Huber JD, Rosen CL.
Neurosurgery. 2014;74(4):382-394.

C-reactive protein and long-term ischemic stroke prognosis.
VanGilder RL, Davidov DM, Stinehart KR, Huber JD, Turner RC, Wilson KS, Haney E, Davis SM, Chantler PD, Theeke L, Rosen CL, Crocco TJ, Gutmann L, Barr TL.
J Clin Neurosci. 2014;21(4):547-553.


Bryostatin improves survival and reduces ischemic brain injury in aged rats after acute ischemic stroke.
Tan Z, Turner RC, Leon RL, Li X, Hongpaisan J, Zheng W, Logsdon AF, Naser ZJ, Alkon DL, Rosen CL, Huber JD.
Stroke. 2013;44(12):3490-3497.


The science of cerebral ischemia and the quest for neuroprotection: navigating past failure to future success.
Turner RC, Dodson SC, Rosen CL, Huber JD.
J Neurosurg. 2013;118(5):1072-1085.


Modeling clinically relevant blast parameters based on scaling principles produces functional & histological deficits in rats.
Turner RC, Naser ZJ, Logsdon AF, DiPasquale KH, Jackson GJ, Robson MJ, Gettens RT, Matsumoto RR, Huber JD, Rosen CL.
Exp Neurol. 2013;248:520-529.

Neuroprotection for ischemic stroke: moving past shortcomings and identifying promising directions.
Turner RC, Lucke-Wold B, Lucke-Wold N, Elliott AS, Logsdon AF, Rosen CL, Huber JD.
Int J Mol Sci. 2013;14(1):1890-1917.


Microplate-bridge technique for watertight dural closures in the combined petrosal approach.
Kusumi M, Fukushima T, Aliabadi H, Mehta AI, Noro S, Rosen CL, Fujii K.
Neurosurgery. 2012;70(2 Suppl Operative):264-269.

Worsened outcome from middle cerebral artery occlusion in aged rats receiving 17beta-estradiol.
Leon RL, Li X, Huber JD, Rosen CL.
Endocrinology. 2012;153(7):3386-3393.


Age and the metabolic syndrome as risk factors for ischemic stroke: improving preclinical models of ischemic stroke.
Lucke-Wold BP, Turner RC, Lucke-Wold AN, Rosen CL, Huber JD.
Yale J Biol Med. 2012;85(4):523-539.


Cerebrovascular disorders: role of aging.
Popa-Wagner A, Buga AM, Turner RC, Rosen CL, Toescu E.
J Aging Res. 2012;2012:128146


Effect of slosh mitigation on histologic markers of traumatic brain injury: laboratory investigation.
Turner RC, Naser ZJ, Bailes JE, Smith DW, Fisher JA, Rosen CL.
J Neurosurg. 2012;117(6):1110-1118.

Effects of aging on behavioral assessment performance: implications for clinically relevant models of neurological disease.
Turner RC, Seminerio MJ, Naser ZJ, Ford JN, Martin SJ, Matsumoto RR, Rosen CL, Huber JD.
J Neurosurg. 2012;117(3):629-637.

The transcriptome of cerebral ischemia.
VanGilder RL, Huber JD, Rosen CL, Barr TL.
Brain Res Bull. 2012;88(4):313-319.


Potential age-dependent effects of estrogen on neural injury.
Leon RL, Huber JD, Rosen CL.
Am J Pathol. 2011;178(6):2450-2460.


Results of the prospective, randomized, multicenter clinical trial evaluating a biosynthesized cellulose graft for repair of dural defects.
Rosen CL, Steinberg GK, DeMonte F, Delashaw JB, Jr., Lewis SB, Shaffrey ME, Aziz K, Hantel J, Marciano FF.
Neurosurgery. 2011;69(5):1093-1103.

Cervical abnormalities causing vertebral artery dissection in children.
Sedney CL, Rosen CL.
J Neurosurg Pediatr. 2011;7(3):272-275.

A survey study of occupational pain and injury in ophthalmic plastic surgeons.
Sivak-Callcott JA, Diaz SR, Ducatman AM, Rosen CL, Nimbarte AD, Sedgeman JA.
Ophthal Plast Reconstr Surg. 2011;27(1):28-32.

Medical management of cerebellar abscess: a case report and review of the literature.
Turner RC, Dodson SC, Rosen CL.
WV Med J. 2011;107(2):21-23.

Targeting the neurovascular unit for treatment of neurological disorders.
VanGilder RL, Rosen CL, Barr TL, Huber JD.
Pharmacol Ther. 2011;130(3):239-247.


Preliminary observation on predicting the need for coil extraction during microsurgery: the clip-coil ratio.
Bulsara KR, Hoh B, Rosen CL, Tanikawa R, Carpenter J.
Acta Neurochir (Wien). 2010;152(3):431-434.

Age exaggerates proinflammatory cytokine signaling and truncates signal transducers and activators of transcription 3 signaling following ischemic stroke in the rat.
DiNapoli VA, Benkovic SA, Li X, Kelly KA, Miller DB, Rosen CL, Huber JD, O'Callaghan JP.
Neuroscience. 2010;170(2):633-644.


Changes in NADPH oxidase isoform expression after middle cerebral artery occlusion in aged female rats.
Kelly KA, Li XL, Rosen CL, Huber JD.
Stroke. 2010;41(4):E284-E284.

Novel technique to improve vessel mismatch when using saphenous vein bypass grafts for intracranial revascularization procedures.
Marhold F, Rosen CL.
J Neurosurg. 2010;112(6):1227-1231.

Pathophysiology of the vascular wall and its relevance for cerebrovascular disorders in aged rodents.
Popa-Wagner A, Pirici D, Petcu EB, Mogoanta L, Buga AM, Rosen CL, Leon R, Huber JD.
Curr Neurovasc Res. 2010;7(3):251-267.

NOX2 inhibition with apocynin worsens stroke outcome in aged rats.
Kelly KA, Li XL, Tan ZJ, VanGilder RL, Rosen CL, Huber JD.
Brain Res. 2009;1292:165-172.


Plasminogen activator inhibitor type 1 derived peptide, EEIIMD, diminishes cortical infarct but fails to improve neurological function in aged rats following middle cerebral artery occlusion.
Tan ZJ, Li XL, Kelly KA, Rosen CL, Huber JD.
Brain Res. 2009;1281:84-90.


Early disruptions of the blood-brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats.
DiNapoli VA, Huber JD, Houser KA, Li X, Rosen CL.
Neurobiol Aging. 2008;29(5):753-764.


Subaxial positional vertebral artery occlusion corrected by decompression and fusion.
Miele VJ, France JC, Rosen CL.
Spine (Phila Pa 1976). 2008;33(11):E366-E370.

Single-stage complex reconstruction for fibrous dysplasia: a case report.
Rosen CL, Sedney C, Sivak J.
Skull Base. 2008;18(4):275-279.


Chordoma of the anterior cranial fossa and ethmoids with orbital involvement.
Vidor I, Sivak-Callcott JA, Rosen CL, Rassekh CH, Williams HJ, Ellis BD.
Orbit. 2008;27(6):444-450.

Selective MCA occlusion: a precise embolic stroke model.
DiNapoli VA, Rosen CL, Nagamine T, Crocco T.
J Neurosci Methods. 2006;154(1-2):233-238.

Malignant optic nerve glioma (glioblastoma multiforme): A case report and literature review.
Hartel PH, Rosen CL, Larzo C, Nestor S.
WV Med J. 2006;102(4):29-31.

Calculation of isoeffective doses and the alpha/beta value by comparing results following radiosurgery and radiotherapy for arteriovenous malformations of the brain.
Karlsson B, Lax I, Yamamoto M, Soderman M, Jokura H, Rosen CL, Bailes JE.
J Neurosurg. 2006;105 Suppl:183-189.

Vertebral artery-to-middle cerebral artery bypass with coil embolization of giant internal carotid artery aneurysm: technical case report.
Miele VJ, Rosen CL, Carpenter J, Rai A, Bailes JE.
Neurosurgery. 2005;56(5):E1159

Epidural blood patch at C2: diagnosis and treatment of spontaneous intracranial hypotension.
Rai A, Rosen CL, Carpenter J, Miele V.
AJNR Am J Neuroradiol. 2005;26(10):2663-2666.

Influence of age on stroke outcome following transient focal ischemia.
Rosen CL, DiNapoli VA, Nagamine T, Crocco T.
J Neurosurg. 2005;103(4):687-694.

Sinus pericranii: clinical and imaging findings in two cases of spontaneous partial thrombosis.
Carpenter JS, Rosen CL, Bailes JE, Gailloud P.
AJNR Am J Neuroradiol. 2004;25(1):121-125.

Neurological injury and death in all-terrain vehicle crashes in West Virginia: a 10-year retrospective review.
Carr AM, Bailes JE, Helmkamp JC, Rosen CL, Miele VJ.
Neurosurgery. 2004;54(4):861-866.

Gaze-evoked amaurosis associated with an intracranial aneurysm.
Sivak-Callcott J, Carpenter JS, Rosen CL, Ellis B, Hix C.
Arch Ophthalmol. 2004;122(9):1404-1406.

Outcome analysis of preoperative embolization in cranial base surgery.
Rosen CL, Ammerman JM, Sekhar LN, Bank WO.
Acta Neurochir (Wien). 2002;144(11):1157-1164.

Primary angiitis of the central nervous system as a first presentation in Hodgkin's disease: a case report and review of the literature.
Rosen CL, DePalma L, Morita A.
Neurosurgery. 2000;46(6):1504-1508.

Use of intra-aortic balloon pump counterpulsation for refractory symptomatic vasospasm.
Rosen CL, Sekhar LN, Duong DH.
Acta Neurochir (Wien). 2000;142(1):25-32.

Proposed grading system to predict the extent of resection and outcomes for cranial base meningiomas.
Levine ZT, Buchanan RI, Sekhar LN, Rosen CL, Wright DC.
Neurosurgery. 1999;45(2):221-230.

Ran-2, a glial lineage marker, is a GPI-anchored form of ceruloplasmin.
Salzer JL, Lovejoy L, Linder MC, Rosen CL.
J Neurosci Res. 1998;54(2):147-157.

Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules.
Struyk AF, Canoll PD, Wolfgang MJ, Rosen CL, D'Eustachio P, Salzer JL.
J Neurosci. 1995;15(3 Pt 2):2141-2156.

Expression of unique sets of GPI-linked proteins by different primary neurons in vitro.
Rosen CL, Lisanti MP, Salzer JL.
J Cell Biol. 1992;117(3):617-627.


Myelin formation following transplantation of normal fetal glia into myelin-deficient rat spinal cord.
Rosenbluth J, Hasegawa M, Shirasaki N, Rosen CL, Liu Z.
J Neurocytol. 1990;19(5):718-730.

Type 1 astrocytes inhibit myelination by adult rat oligodendrocytes in vitro.
Rosen CL, Bunge RP, Ard MD, Wood PM.
J Neurosci. 1989;9(10):3371-3379.