Publications of Michael J Ruppert, MD, PhD

Kruppel-like pluripotency factors as modulators of cancer cell therapeutic responses.
Farrugia MK, Vanderbilt DB, Salkeni MA, Ruppert JM.
Cancer Res. 2016;76(7):1677-1682.

PMC4873413.

KAP1 promotes proliferation and metastatic progression of breast cancer cells.
Addison JB, Koontz C, Fugett JH, Creighton CJ, Chen D, Farrugia MK, Padon RR, Voronkova MA, McLaughlin SL, Livengood RH, Lin CC, Ruppert JM, Pugacheva EN, Ivanov AV.
Cancer Res. 2015;75(2):344-355.

PMC4297582.

SOX9 inhibits beta-TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties.
Deng W, Vanderbilt DB, Lin CC, Martin KH, Brundage KM, Ruppert JM.
J.Cell Sci. 2015;128(6):1123-1138.

PMC4359920.

Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer.
Farrugia MK, Sharma SB, Lin CC, McLaughlin SL, Vanderbilt DB, Ammer AG, Salkeni MA, Stoilov P, Agazie YM, Creighton CJ, Ruppert JM.
Cell Death Dis. 2015;6:e1699

PMC4385942.

Kruppel-like factor 4 signals through microRNA-206 to promote tumor initiation and cell survival.
Lin CC, Sharma SB, Farrugia MK, McLaughlin SL, Ice RJ, Loskutov YV, Pugacheva EN, Brundage KM, Chen D, Ruppert JM.
Oncogenesis. 2015;4:e155

PMC4753526.

MicroRNA-based therapeutic strategies for targeting mutant and wild type RAS in cancer.
Sharma SB, Ruppert JM.
Drug Dev.Res. 2015;76(6):328-342.

PMC4758903.

microRNAs-206 and -21 cooperate to promote RAS-ERK signaling by suppressing the translation of RASA1 and SPRED1.
Sharma SB, Lin CC, Farrugia MK, McLaughlin SL, Ellis EJ, Brundage KM, Salkeni MA, Ruppert JM.
Mol Cell Biol. 2014;34(22):4143-4164.

PMC4248710.

A KLF4-miRNA-206 autoregulatory feedback loop can promote or inhibit protein translation depending upon cell context.
Lin CC, Liu LZ, Addison JB, Wonderlin WF, Ivanov AV, Ruppert JM.
Mol Cell Biol. 2011;31(12):2513-2527.

PMC3133414.

Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoid.
Jiang W, Deng WT, Bailey SK, Nail CD, Frost AR, Brouillette WJ, Muccio DD, Grubbs CJ, Ruppert JM, Lobo-Ruppert SM.
Cancer Biol Ther. 2009;8(3):289-298.

PMC2776760.

Epithelial transformation by KLF4 requires Notch1 but not canonical Notch1 signaling.
Liu Z, Teng L, Bailey SK, Frost AR, Bland KI, LoBuglio AF, Ruppert JM, Lobo-Ruppert SM.
Cancer Biol Ther. 2009;8(19)

PMC2795010.

Lack of efficacy of the statins atorvastatin and lovastatin in rodent mammary carcinogenesis.
Lubet RA, Boring D, Steele VE, Ruppert JM, Juliana MM, Grubbs CJ.
Cancer Prev.Res.(Phila). 2009;2(2):161-167.


Bad things happen in the basal layer: KLF4 and squamous cell carcinoma.
Jiang W, Lobo-Ruppert SM, Ruppert JM.
Cancer Biol Ther. 2008;7(5):783-785.

PMC2786985.

Gli1 acts through Snail and E-cadherin to promote nuclear signaling by beta-catenin.
Li X, Deng WT, Lobo-Ruppert SM, Ruppert JM.
Oncogene. 2007;26(31):4489-4498.

PMC2233601.