Publications of Michael D Schaller, PhD

The wind god promotes lung cancer.
Frisch SM, Schaller MD.
Cancer Cell. 2014;25(5):551-552.


SRChing for the substrates of Src.
Reynolds AB, Kanner SB, Bouton AH, Schaller MD, Weed SA, Flynn DC, Parsons JT.
Oncogene. 2014;33(37):4537-4547.


Mechanisms that link the oncogenic epithelial-mesenchymal transition to suppression of anoikis.
Frisch SM, Schaller MD, Cieply B.
J Cell Sci. 2013;126(Pt 1):21-29.

PMC3603508.

The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migration.
Hartman ZR, Schaller MD, Agazie YM.
Mol Cancer Res. 2013;11(6):651-664.

PMC3686999.

In vitro phosphorylation of the focal adhesion targeting domain of focal adhesion kinase by SRC kinase.
Cable J, Prutzman K, Gunawardena HP, Schaller MD, Chen X, Campbell SL.
Biochemistry. 2012;51(11):2213-2223.

PMC3332079.

Focal adhesion kinase exploring FAK structure to gain insight into function.
Hall JE, Fu W, Schaller MD.
Int Rev Cell Mol Biol. 2011;288:185-225.


PTP-PEST controls motility, adherens junction assembly, and Rho GTPase activity in colon cancer cells.
Espejo R, Rengifo-Cam W, Schaller MD, Evers BM, Sastry SK.
Am J Physiol Cell Physiol. 2010;299(2):C454-C463.

PMC2928632.

PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.
Schaller MD, Frisch SM.
Cancer Biol Ther. 2010;9(10):791-793.


Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions.
Schaller MD.
J Cell Sci. 2010;123(Pt 7):1007-1013.


Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis.
Sood AK, Armaiz-Pena GN, Halder J, Nick AM, Stone RL, Hu W, Carroll AR, Spannuth WA, Deavers MT, Allen JK, Han LY, Kamat AA, Shahzad MM, McIntyre BW, Diaz-Montero CM, Jennings NB, Lin YG, Merritt WM, DeGeest K, Vivas-Mejia PE, Lopez-Berestein G, Schaller MD, Cole SW, Lutgendorf SK.
J Clin Invest. 2010;120(5):1515-1523.

PMC2860925.

Activation of Src kinase by protein-tyrosine phosphatase-PEST in osteoclasts: comparative analysis of the effects of bisphosphonate and protein-tyrosine phosphatase inhibitor on Src activation in vitro.
Chellaiah MA, Schaller MD.
J Cell Physiol. 2009;220(2):382-393.


Lipid binding to the tail domain of vinculin: specificity and the role of the N and C termini.
Palmer SM, Playford MP, Craig SW, Schaller MD, Campbell SL.
J Biol Chem. 2009;284(11):7223-7231.

PMC2652276.

Spatial and temporal regulation of focal adhesion kinase activity in living cells.
Cai X, Lietha D, Ceccarelli DF, Karginov AV, Rajfur Z, Jacobson K, Hahn KM, Eck MJ, Schaller MD.
Mol Cell Biol. 2008;28(1):201-214.

PMC2223290.

Vinculin Tail conformation and self-association is independent of pH and H906 protonation.
Palmer SM, Schaller MD, Campbell SL.
Biochemistry. 2008;


Focal adhesion kinase regulates cell-cell contact formation in epithelial cells via modulation of Rho.
Playford MP, Vadali K, Cai X, Burridge K, Schaller MD.
Exp Cell Res. 2008;314(17):3187-3197.

PMC2613854.

Calcium-dependent Pyk2 activation: a role for calmodulin?
Schaller MD.
Biochem J. 2008;410(3):e3-e4.


Multiple paxillin binding sites regulate FAK function.
Scheswohl DM, Harrell JR, Rajfur Z, Gao G, Campbell SL, Schaller MD.
J Mol Signal. 2008;3:1

PMC2246129.

Structural basis for the autoinhibition of focal adhesion kinase.
Lietha D, Cai X, Ceccarelli DF, Li Y, Schaller MD, Eck MJ.
Cell. 2007;129(6):1177-1187.

PMC2077847.

Focal adhesion kinase: an essential kinase in the regulation of cardiovascular functions.
Vadali K, Cai X, Schaller MD.
IUBMB Life. 2007;59(11):709-716.


CIB1 regulates endothelial cells and ischemia-induced pathological and adaptive angiogenesis.
Zayed MA, Yuan W, Leisner TM, Chalothorn D, McFadden AW, Schaller MD, Hartnett ME, Faber JE, Parise LV.
Circ Res. 2007;101(11):1185-1193.


Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement.
Cai X, Li M, Vrana J, Schaller MD.
Mol Cell Biol. 2006;26(7):2857-2868.

PMC1430314.

Crystal structure of the FERM domain of focal adhesion kinase.
Ceccarelli DF, Song HK, Poy F, Schaller MD, Eck MJ.
J Biol Chem. 2006;281(1):252-259.


Identification of a filamin docking site on PTP-PEST.
Playford MP, Lyons PD, Sastry SK, Schaller MD.
J Biol Chem. 2006;281(45):34104-34112.


Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.
Cai L, Holoweckyj N, Schaller MD, Bear JE.
J Biol Chem. 2005;280(36):31913-31923.


Focal adhesion kinase silencing augments docetaxel-mediated apoptosis in ovarian cancer cells.
Halder J, Landen CN, Jr., Lutgendorf SK, Li Y, Jennings NB, Fan D, Nelkin GM, Schmandt R, Schaller MD, Sood AK.
Clin Cancer Res. 2005;11(24 Pt 1):8829-8836.


Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activities.
Horner TJ, Osawa S, Schaller MD, Weiss ER.
J Biol Chem. 2005;280(31):28241-28250.


In situ photoactivation of a caged phosphotyrosine peptide derived from focal adhesion kinase temporarily halts lamellar extension of single migrating tumor cells.
Humphrey D, Rajfur Z, Vazquez ME, Scheswohl DM, Schaller MD, Jacobson K, Imperiali B.
J Biol Chem. 2005;280(23):22091-22101.


Measurement of protein tyrosine phosphorylation in cell adhesion.
Iyer VV, Ballestrem C, Kirchner J, Geiger B, Schaller MD.
Methods Mol Biol. 2005;294:289-302.


New insights into FAK signaling and localization based on detection of a FAT domain folding intermediate.
Dixon RD, Chen Y, Ding F, Khare SD, Prutzman KC, Schaller MD, Campbell SL, Dokholyan NV.
Structure. 2004;12(12):2161-2171.


FERM domain interaction promotes FAK signaling.
Dunty JM, Gabarra-Niecko V, King ML, Ceccarelli DF, Eck MJ, Schaller MD.
Mol Cell Biol. 2004;24(12):5353-5368.

PMC419890.

NMR solution structure of the focal adhesion targeting domain of focal adhesion kinase in complex with a paxillin LD peptide: evidence for a two-site binding model.
Gao G, Prutzman KC, King ML, Scheswohl DM, DeRose EF, London RE, Schaller MD, Campbell SL.
J Biol Chem. 2004;279(9):8441-8451.


Phosphorylation of paxillin by p38MAPK is involved in the neurite extension of PC-12 cells.
Huang C, Borchers CH, Schaller MD, Jacobson K.
J Cell Biol. 2004;164(4):593-602.

PMC2171993.

MAP kinases and cell migration.
Huang C, Jacobson K, Schaller MD.
J Cell Sci. 2004;117(Pt 20):4619-4628.


A role for JNK-paxillin signaling in cell migration.
Huang C, Jacobson K, Schaller MD.
Cell Cycle. 2004;3(1):4-6.


The interplay between Src and integrins in normal and tumor biology.
Playford MP, Schaller MD.
Oncogene. 2004;23(48):7928-7946.


The focal adhesion targeting domain of focal adhesion kinase contains a hinge region that modulates tyrosine 926 phosphorylation.
Prutzman KC, Gao G, King ML, Iyer VV, Mueller GA, Schaller MD, Campbell SL.
Structure. 2004;12(5):881-891.


FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?
Schaller MD.
J Cell Biol. 2004;166(2):157-159.

PMC2172300.

Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion.
Sood AK, Coffin JE, Schneider GB, Fletcher MS, DeYoung BR, Gruman LM, Gershenson DM, Schaller MD, Hendrix MJ.
Am J Pathol. 2004;165(4):1087-1095.

PMC1618649.

A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src.
Carragher NO, Westhoff MA, Fincham VJ, Schaller MD, Frame MC.
Curr Biol. 2003;13(16):1442-1450.


FAK regulates biological processes important for the pathogenesis of cancer.
Gabarra-Niecko V, Schaller MD, Dunty JM.
Cancer Metastasis Rev. 2003;22(4):359-374.


JNK phosphorylates paxillin and regulates cell migration.
Huang C, Rajfur Z, Borchers CH, Schaller MD, Jacobson K.
Nature. 2003;424(6945):219-223.


Tyrosine phosphorylation of type Igamma phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch.
Ling K, Doughman RL, Iyer VV, Firestone AJ, Bairstow SF, Mosher DF, Schaller MD, Anderson RA.
J Cell Biol. 2003;163(6):1339-1349.

PMC2173703.

The N termini of focal adhesion kinase family members regulate substrate phosphorylation, localization, and cell morphology.
Dunty JM, Schaller MD.
J Biol Chem. 2002;277(47):45644-45654.


Characterization of an activated mutant of focal adhesion kinase: 'SuperFAK'.
Gabarra-Niecko V, Keely PJ, Schaller MD.
Biochem J. 2002;365(Pt 3):591-603.

PMC1222731.

PTP-PEST controls motility through regulation of Rac1.
Sastry SK, Lyons PD, Schaller MD, Burridge K.
J Cell Sci. 2002;115(Pt 22):4305-4316.


Inhibition of the catalytic activity of cell adhesion kinase beta by protein-tyrosine phosphatase-PEST-mediated dephosphorylation.
Lyons PD, Dunty JM, Schaefer EM, Schaller MD.
J Biol Chem. 2001;276(26):24422-24431.


Paxillin: a focal adhesion-associated adaptor protein.
Schaller MD.
Oncogene. 2001;20(44):6459-6472.


Biochemical signals and biological responses elicited by the focal adhesion kinase.
Schaller MD.
Biochim Biophys Acta. 2001;1540(1):1-21.


Multiple stimuli induce tyrosine phosphorylation of the Crk-binding sites of paxillin.
Schaller MD, Schaefer EM.
Biochem J. 2001;360(Pt 1):57-66.

PMC1222202.

Paxillin binding is not the sole determinant of focal adhesion localization or dominant-negative activity of focal adhesion kinase/focal adhesion kinase-related nonkinase.
Cooley MA, Broome JM, Ohngemach C, Romer LH, Schaller MD.
Mol Biol Cell. 2000;11(9):3247-3263.

PMC14989.

UNC112. A new regulator of cell-extracellular matrix adhesions?
Schaller MD.
J Cell Biol. 2000;150(1):F9-F11.

PMC2185552.

The noncatalytic domain of protein-tyrosine phosphatase-PEST targets paxillin for dephosphorylation in vivo.
Shen Y, Lyons PD, Cooley MA, Davidson D, Veillette A, Salgia R, Griffin JD, Schaller MD.
J Biol Chem. 2000;275(2):1405-1413.


Complex formation with focal adhesion kinase: a mechanism to regulate activity and subcellular localization of Src kinases.
Schaller MD, Hildebrand JD, Parsons JT.
Mol Biol Cell. 1999;10(10):3489-3505.

PMC25619.

NCAM stimulates the Ras-MAPK pathway and CREB phosphorylation in neuronal cells.
Schmid RS, Graff RD, Schaller MD, Chen SL, Schachner M, Hemperly JJ, Maness PF.
J Neurobiol. 1999;38(4):542-558.


Focal adhesion targeting: the critical determinant of FAK regulation and substrate phosphorylation.
Shen Y, Schaller MD.
Mol Biol Cell. 1999;10(8):2507-2518.

PMC25482.

The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillin.
Thomas JW, Cooley MA, Broome JM, Salgia R, Griffin JD, Lombardo CR, Schaller MD.
J Biol Chem. 1999;274(51):36684-36692.


Direct association of protein-tyrosine phosphatase PTP-PEST with paxillin.
Shen Y, Schneider GB, Cloutier JF, Veillette A, Schaller MD.
J Biol Chem. 1998;273(11):6474-6481.


SH2- and SH3-mediated interactions between focal adhesion kinase and Src.
Thomas JW, Ellis B, Boerner RJ, Knight WB, White GC, Schaller MD.
J Biol Chem. 1998;273(1):577-583.


Signaling through the focal adhesion kinase.
Schaller MD.
Soc Gen Physiol Ser. 1997;52:241-255.


Differential signaling by the focal adhesion kinase and cell adhesion kinase beta.
Schaller MD, Sasaki T.
J Biol Chem. 1997;272(40):25319-25325.


The focal adhesion kinase.
Schaller MD.
J Endocrinol. 1996;150(1):1-7.


Interaction of focal adhesion kinase with cytoskeletal protein talin.
Chen HC, Appeddu PA, Parsons JT, Hildebrand JD, Schaller MD, Guan JL.
J Biol Chem. 1995;270(28):16995-16999.


Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase.
Hildebrand JD, Schaller MD, Parsons JT.
Mol Biol Cell. 1995;6(6):637-647.

PMC301225.

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.
Schaller MD, Otey CA, Hildebrand JD, Parsons JT.
J Cell Biol. 1995;130(5):1181-1187.

PMC2120552.

pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk.
Schaller MD, Parsons JT.
Mol Cell Biol. 1995;15(5):2635-2645.

PMC230493.

Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.
Cobb BS, Schaller MD, Leu TH, Parsons JT.
Mol Cell Biol. 1994;14(1):147-155.

PMC358365.

SH2 domain specificity and activity modified by a single residue.
Marengere LE, Songyang Z, Gish GD, Schaller MD, Parsons JT, Stern MJ, Cantley LC, Pawson T.
Nature. 1994;369(6480):502-505.


Focal adhesion kinase: structure and signalling.
Parsons JT, Schaller MD, Hildebrand J, Leu TH, Richardson A, Otey CA.
J Cell Sci Suppl. 1994;18:109-113.


Focal adhesion kinase and associated proteins.
Schaller MD, Parsons JT.
Curr Opin Cell Biol. 1994;6(5):705-710.


Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src.
Schaller MD, Hildebrand JD, Shannon JD, Fox JW, Vines RR, Parsons JT.
Mol Cell Biol. 1994;14(3):1680-1688.

PMC358526.

Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions.
Hildebrand JD, Schaller MD, Parsons JT.
J Cell Biol. 1993;123(4):993-1005.

PMC2200138.

Identification and characterization of novel substrates for protein tyrosine kinases.
Schaller MD, Bouton AH, Flynn DC, Parsons JT.
Prog Nucleic Acid Res Mol Biol. 1993;44:205-227.


Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK.
Schaller MD, Borgman CA, Parsons JT.
Mol Cell Biol. 1993;13(2):785-791.

PMC358961.

Focal adhesion kinase: an integrin-linked protein tyrosine kinase.
Schaller MD, Parsons JT.
Trends Cell Biol. 1993;3(8):258-262.


Tyrosine phosphorylation of the focal adhesion kinase pp125FAK during development: relation to paxillin.
Turner CE, Schaller MD, Parsons JT.
J Cell Sci. 1993;105 ( Pt 3):637-645.


Tyrosine phosphorylation of a 120,000 dalton membrane-associated protein by the neural form of pp60c-src, pp60c-src+.
Flynn DC, Schaller MD, Parsons JT.
Oncogene. 1992;7(3):579-583.


Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets.
Lipfert L, Haimovich B, Schaller MD, Cobb BS, Parsons JT, Brugge JS.
J Cell Biol. 1992;119(4):905-912.

PMC2289696.

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.
Schaller MD, Borgman CA, Cobb BS, Vines RR, Reynolds AB, Parsons JT.
Proc Natl Acad Sci USA. 1992;89(11):5192-5196.

PMC49256.