Publications of David M Smith, PhD

ATP binding to neighbouring subunits and intersubunit allosteric coupling underlie proteasomal ATPase function.
Kim YC, Snoberger A, Schupp J, Smith DM.
Nat Commun. 2015;6:8520


A conserved F box regulatory complex controls proteasome activity in Drosophila.
Bader M, Benjamin S, Wapinski OL, Smith DM, Goldberg AL, Steller H.
Cell. 2011;145(3):371-382.


Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry.
Deriziotis P, Andre R, Smith DM, Goold R, Kinghorn KJ, Kristiansen M, Nathan JA, Rosenzweig R, Krutauz D, Glickman MH, Collinge J, Goldberg AL, Tabrizi SJ.
EMBO J. 2011;30(15):3065-3077.


ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle.
Smith DM, Fraga H, Reis C, Kafri G, Goldberg AL.
Cell. 2011;144(4):526-538.


Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome-ATPase interactions.
Yu Y, Smith DM, Kim HM, Rodriguez V, Goldberg AL, Cheng Y.
EMBO J. 2010;29(3):692-702.


Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases.
Rabl J, Smith DM, Yu Y, Chang SC, Goldberg AL, Cheng Y.
Mol Cell. 2008;30(3):360-368.

ATP-induced structural transitions in PAN, the proteasome-regulatory ATPase complex in Archaea.
Horwitz AA, Navon A, Groll M, Smith DM, Reis C, Goldberg AL.
J Biol Chem. 2007;282(31):22921-22929.

Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry.
Smith DM, Chang SC, Park S, Finley D, Cheng Y, Goldberg AL.
Mol Cell. 2007;27(5):731-744.


Differential effects of proteasome inhibitors on cell cycle and apoptotic pathways in human YT and Jurkat cells.
Lu M, Dou QP, Kitson RP, Smith DM, Goldfarb RH.
J Cell Biochem. 2006;97(1):122-134.

Proteasomes and their associated ATPases: a destructive combination.
Smith DM, Benaroudj N, Goldberg A.
J Struct Biol. 2006;156(1):72-83.

Naturally occurring proteasome inhibitors from mate tea (Ilex paraguayensis) serve as models for topical proteasome inhibitors.
Arbiser JL, Li XC, Hossain CF, Nagle DG, Smith DM, Miller P, Govindarajan B, DiCarlo J, Landis-Piwowar KR, Dou QP.
J Invest Dermatol. 2005;125(2):207-212.

Smith DM, Daniel KG, Dou QP.
Lett Drug Des Discov. 2005;2:74-81.

ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins.
Smith DM, Kafri G, Cheng Y, Ng D, Walz T, Goldberg AL.
Mol Cell. 2005;20(5):687-698.

Docking studies and model development of tea polyphenol proteasome inhibitors: applications to rational drug design.
Smith DM, Daniel KG, Wang Z, Guida WC, Chan TH, Dou QP.
Proteins. 2004;54(1):58-70.

Interruption of tumor cell cycle progression through proteasome inhibition: implications for cancer therapy.
Dou QP, Smith DM, Daniel KG, Kazi A.
Prog Cell Cycle Res. 2003;5:441-446.

Inhibition of the proteasome activity, a novel mechanism associated with the tumor cell apoptosis-inducing ability of genistein.
Kazi A, Daniel KG, Smith DM, Kumar NB, Dou QP.
Biochem Pharmacol. 2003;66(6):965-976.

Overexpression of interleukin-2 receptor alpha in a human squamous cell carcinoma of the head and neck cell line is associated with increased proliferation, drug resistance, and transforming ability.
Kuhn DJ, Smith DM, Pross S, Whiteside TL, Dou QP.
J Cell Biochem. 2003;89(4):824-836.

Potential molecular targets of tea polyphenols in human tumor cells: significance in cancer prevention.
Kazi A, Smith DM, Daniel KG, Zhong S, Gupta P, Bosley ME, Dou QP.
In Vivo. 2002;16(6):397-403.

Inhibition of bcl-x(l) phosphorylation by tea polyphenols or epigallocatechin-3-gallate is associated with prostate cancer cell apoptosis.
Kazi A, Smith DM, Zhong Q, Dou QP.
Mol Pharmacol. 2002;62(4):765-771.

A novel beta-lactam antibiotic activates tumor cell apoptotic program by inducing DNA damage.
Smith DM, Kazi A, Smith L, Long TE, Heldreth B, Turos E, Dou QP.
Mol Pharmacol. 2002;61(6):1348-1358.

Synthetic analogs of green tea polyphenols as proteasome inhibitors.
Smith DM, Wang Z, Kazi A, Li LH, Chan TH, Dou QP.
Mol Med. 2002;8(7):382-392.


Tannic acid potently inhibits tumor cell proteasome activity, increases p27 and Bax expression, and induces G1 arrest and apoptosis.
Nam S, Smith DM, Dou QP.
Cancer Epidemiol Biomarkers Prev. 2001;10(10):1083-1088.

Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo.
Nam S, Smith DM, Dou QP.
J Biol Chem. 2001;276(16):13322-13330.

Green tea polyphenol epigallocatechin inhibits DNA replication and consequently induces leukemia cell apoptosis.
Smith DM, Dou QP.
Int J Mol Med. 2001;7(6):645-652.