Identifying causal networks linking cancer processes and anti-tumor immunity using Bayesian network inference and metagene constructs.
Kaiser JL, Bland CL, Klinke DJ.
Biotechnol Prog. 2016; [Epub ahead of print]

CD44S-hyaluronan interactions protect cells resulting from EMT against anoikis.
Cieply B, Koontz C, Frisch SM.
Matrix Biol. 2015;48(55):65

Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer.
Farrugia MK, Sharma SB, Lin CC, McLaughlin SL, Vanderbilt DB, Ammer AG, Salkeni MA, Stoilov P, Agazie YM, Creighton CJ, Ruppert JM.
Cell Death Dis. 2015;6:e1699


Enhancing the discovery and development of immunotherapies for cancer using quantitative and systems pharmacology: Interleukin-12 as a case study.
Klinke DJ.
J Immunother Cancer. 2015;3:27


Interlocked positive and negative feedback network motifs regulate beta-catenin activity in the adherens junction pathway.
Klinke DJ, Horvath N, Cuppett V, Wu Y, Deng W, Kanj R.
Mol Biol Cell. 2015;26(22):4135-4148.

PMC Journal - In Process.

In silico model-based inference: an emerging approach for inverse problems in engineering better medicines.
Klinke DJ, Birtwistle MR.
Curr Opin Chem Eng. 2015;10:14-24.


Inhibition of autophagy potentiated the antitumor effect of nedaplatin in cisplatin-resistant nasopharyngeal carcinoma cells.
Liu Z, Liu J, Li L, Nie D, Tao Q, Wu J, Fan J, Lin C, Zhao S, Ju D.
PLoS One. 2015;10(8):e0135236


Tumor and stromal-based contributions to head and neck squamous cell carcinoma invasion.
Markwell SM, Weed SA.
Cancers (Basel). 2015;7(1):382-406.


Orchestration of ErbB3 signaling through heterointeractions and homointeractions.
McCabe PM, Steinkamp MP, Halasz AM, Chen Y, Yang S, Smith MS, Zahoransky-Kohalmi G, Swift M, Xu XP, Hanien D, Volkmann N, Lidke DS, Edwards JS, Wilson BS.
Mol Biol Cell. 2015;26(22):4109-4123.


Alternative splicing shapes the phenotype of a mutation in BBS8 to cause nonsyndromic Retinitis Pigmentosa.
Murphy D, Singh R, Kolandaivelu S, Ramamurthy V, Stoilov P.
Mol Cell Biol. 2015;35(10):1860-1870.


Rescue of DNA-PK signaling and T-Cell differentiation by targeted genome editing in a prkdc deficient iPSC disease model.
Rahman SH, Kuehle J, Reimann C, Mlambo T, Alzubi J, Maeder ML, Riedel H, Fisch P, Cantz T, Rudolph C, Mussolino C, Joung JK, Schambach A, Cathomen T.
PLoS Genet. 2015;11(5):e1005239


High-frequency ultrasound imaging of mouse cervical lymph nodes.
Walk EL, McLaughlin SL, Weed SA.
J Vis Exp. 2015;(101):e52718

CD8 (+) T cell response to adenovirusvaccination and subsequent suppression of tumor growth: modeling, simulation and analysis.
Wang Q, Klinke DJ, Wang Z.
BMC Syst Biol. 2015;9:27


Exosomes: improved methods to characterize their morphology, RNA content, and surface protein biomarkers.
Wu Y, Deng W, Klinke DJ.
Analyst. 2015;140(19):6631-6642.

Exosomes: improved methods to characterize their morphology, RNA content, and surface protein biomarkers.
Wu YT, Deng W, Klinke DJ.
Analyst. 2015;140(19):6631-6642.

Helicobacter pylori FKBP-type PPIase promotes gastric epithelial cell proliferation and anchorage-independent growth through activation of ERK-mediated mitogenic signaling pathway.
Zhu Y, Chen M, Gong Y, Liu Z, Li A, Kang D, Han F, Liu J, Liu J, Yuan Y.
FEMS Microbiol Lett. 2015;362(7)

Late onset of CSF rhinorrhea in a postoperative transsphenoidal surgery patient following robotic-assisted abdominal hysterectomy.
Dowdy JT, Moody MW, Cifarelli CP.
J Investigative Medicine High Impact Case Reports. 2014;2(1):6


The wind god promotes lung cancer.
Frisch SM, Schaller MD.
Cancer Cell. 2014;25(5):551-552.

De novo prediction of PTBP1 binding and splicing targets reveals unexpected features of its RNA recognition and function.
Han A, Stoilov P, Linares AJ, Zhou Y, Fu XD, Black DL.
PLoS Comput Biol. 2014;10(1):e1003442


Induction of Wnt-inducible signaling protein-1 correlates with invasive breast cancer oncogenesis and reduced type 1 cell-mediated cytotoxic immunity: a retrospective study.
Klinke DJ.
PLoS Comput Biol. 2014;10(1):e1003409


In silico model-based inference: A contemporary approach for hypothesis testing in network biology.
Klinke DJ.
Biotechnol Prog. 2014;30(6):1247-1261.


Inferring alterations in cell-to-cell communication in HER2+ breast cancer using secretome profiling of three cell models.
Klinke DJ, Kulkarni YM, Wu Y, Byrne-Hoffman C.
Biotechnol Bioeng. 2014;111(9):1853-1863.


NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner.
Kozyreva VK, McLaughlin SL, Livengood RH, Calkins RA, Kelley LC, Rajulapati A, Ice RJ, Smolkin MB, Weed SA, Pugacheva EN.
Mol Cancer Res. 2014;12(5):681-693.


The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation.
Li Q, Zheng S, Han A, Lin CH, Stoilov P, Fu XD, Black DL.
Elife. 2014;3:e01201


PSP94, an upstream signaling mediator of prostasin found highly elevated in ovarian cancer.
Ma JX, Yan BX, Zhang J, Jiang BH, Guo Y, Riedel H, Mueller MD, Remick SC, Yu JJ.
Cell Death Dis. 2014;5:e1407

PMC Journal – In Process.

NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis.
McLaughlin SL, Ice RJ, Rajulapati A, Kozyulina PY, Livengood RH, Kozyreva VK, Loskutov YV, Culp M, Weed SA, Ivanov AV, Pugacheva EN.
Mol Cancer Res. 2014;12(1):69-81.


Medium throughput analysis of alternative splicing by fluorescently labeled rt-PCR.
Percifield R, Murphy D, Stoilov P.
Methods Mol Biol. 2014;1126:299-313.

SRChing for the substrates of Src.
Reynolds AB, Kanner SB, Bouton AH, Schaller MD, Weed SA, Flynn DC, Parsons JT.
Oncogene. 2014;33(37):4537-4547.

Loss of cytokeratin 20 and acquisition of thyroid transcription factor-1 expression in a merkel cell carcinoma metastasis to the brain.
Shalin SC, Cifarelli CP, Suen JY, Gao L.
Am J Dermatopathol. 2014;36(11):904-906.


Use of high frequency ultrasound to monitor cervical lymph node alterations in mice.
Walk EL, McLaughlin S, Coad JE, Weed SA.
PLoS One. 2014;9(6):e100185


PSP94 contributes to chemoresistance and its peptide derivative PCK3145 represses tumor growth in ovarian cancer.
Yan BX, Ma JX, Zhang J, Guo Y, Riedel H, Mueller MD, Remick SC, Yu JJ.
Oncogene. 2014;33(45):5288-5294.

Epithelial-mesenchymal transition and tumor suppression are controlled by a reciprocal feedback loop between ZEB1 and Grainyhead-like-2.
Cieply B, Farris J, Denvir J, Ford H, Frisch SM.
Cancer Res. 2013;15(73):6299-6309.


Mechanisms that link the oncogenic epithelial-mesenchymal transition to suppression of anoikis.
Frisch SM, Schaller MD, Cieply B.
J Cell Sci. 2013;126(Pt 1):21-29.


Splice isoforms of phosducin-like protein control the expression of heterotrimeric G proteins.
Gao X, Sinha S, Belcastro M, Woodard C, Ramamurthy V, Stoilov P, Sokolov M.
J Biol Chem. 2013;288(36):25760-25768.


The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migration.
Hartman ZR, Schaller MD, Agazie YM.
Mol Cancer Res. 2013;11(6):651-664.


Ableson kinases negatively regulate invadopodia function and invasion in head and neck squamous cell carcinoma by inhibiting an HB-EGF autocrine loop.
Hayes KE, Walk EL, Ammer AG, Kelley LC, Martin KH, Weed SA.
Oncogene. 2013;32(40):4766-4777.


Differential proteomic analysis of caveolin-1 KO cells reveals Sh2b3 and Clec12b as novel interaction partners of caveolin-1 and Capns1 as a potential mediator of caveolin-1-induced apoptosis.
Kulkarni YM, Liu C, Qi Q, Zhu Y, Klinke DJ, Liu J.
Analyst. 2013;138(22):6986-6996.


Phosphorylation of the alternative mRNA splicing factor 45 (SPF45) by Clk1 regulates its splice site utilization, cell migration and invasion.
Liu Y, Conaway L, Rutherford BJ, Al-Ayoubi AM, Thompson BA, Zheng H, Weed SA, Eblen ST.
Nucleic Acids Res. 2013;41(9):4949-4962.


Metastatic MTLn3 and non-metastatic MTC adenocarcinoma cells can be differentiated by Pseudomonas aeruginosa.
Novotny MJ, Bridge DR, Martin KH, Weed SA, Wysolmerski RB, Olson JC.
Biol Open. 2013;2(9):891-900.


Regulation of anoikis by deleted in breast cancer-1 (DBC1) through NF-kappaB.
Park SH, Riley P, Frisch SM.
Apoptosis. 2013;18(8):949-962.


Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure.
Shen M, Bellaousov S, Hiller M, de La GP, Creamer TP, Malina O, Sperling R, Mathews DH, Stoilov P, Stamm S.
Nucleic Acids Res. 2013;41(6):3819-3832.


Characterization of novel inhibitors of HIV-1 replication that function via alteration of viral RNA processing and rev function.
Wong RW, Balachandran A, Haaland M, Stoilov P, Cochrane A.
Nucleic Acids Res. 2013;41(20):9471-9483.


Cryoelectron tomography reveals the sequential assembly of bacterial flagella in Borrelia burgdorferi.
Zhao XW, Zhang K, Boquoi T, Hu B, Motaleb MA, Miller KA, James ME, Charon NW, Manson MD, Norris SJ, Li CH, Liu J.
Proc Natl Acad Sci USA. 2013;110(35):14390-14395.


The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B.
Anderson ES, Lin CH, Xiao X, Stoilov P, Burge CB, Black DL.
RNA. 2012;18(5):1041-1049.


Chromatin and epigenetic regulation of pre-mRNA processing.
Brown SJ, Stoilov P, Xing Y.
Hum Mol Genet. 2012;21(R1):R90-R96.


In vitro phosphorylation of the focal adhesion targeting domain of focal adhesion kinase by SRC kinase.
Cable J, Prutzman K, Gunawardena HP, Schaller MD, Chen X, Campbell SL.
Biochemistry. 2012;51(11):2213-2223.


The unique paradigm of spirochete motility and chemotaxis.
Charon NW, Cockburn A, Li C, Liu J, Miller KA, Miller MR, Motaleb MA, Wolgemuth CW.
Annu Rev Microbiol. 2012;66:349-370.


Suppression of the epithelial-mesenchymal transition by Grainyhead-like-2.
Cieply B, Riley P, Pifer PM, Widmeyer J, Addison JB, Ivanov AV, Denvir J, Frisch SM.
Cancer Res. 2012;72(9):2440-2453.


Cranial nerve dysfunction following Gamma Knife surgery for pituitary adenomas: long-term incidence and risk factors.
Cifarelli CP, Schlesinger DJ, Sheehan JP.
J Neurosurg. 2012;116(6):1304-1310.

A database de-identification framework to enable direct queries on medical data for secondary use.
Erdal BS, Liu J, Ding J, Chen J, Marsh CB, Kamal J, Clymer BD.
Methods Inf Med. 2012;51(3):229-241.

Src binds cortactin through a SH2 domain cystine-mediated linkage.
Evans JV, Ammer AG, Jett JE, Bolcato CA, Breaux JC, Martin KH, Culp M, Gannett PM, Weed SA.
J Cell Sci. 2012;125(Pt 24):6185-6197.


The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.
Gehman LT, Meera P, Stoilov P, Shiue L, O'Brien JE, Meisler MH, Ares M, Jr., Otis TS, Black DL.
Genes Dev. 2012;26(5):445-460.


Cortactin Is a substrate of activated Cdc42-Associated Kinase 1 (ACK1) during ligand-induced epidermal growth factor receptor downregulation.
Kelley LC, Weed SA.
PLoS One. 2012;7(8):e44363


Quantifying crosstalk among Interferon-gamma, Interleukin-12, and tumor necrosis factor signaling pathways within a TH1 cell model.
Klinke DJ, Cheng N, Chambers E.
Sci Signal. 2012;5(220):ra32


An evolutionary perspective on anti-tumor immunity.
Klinke DJ.
Front Oncol. 2012;2:202


Understanding immunology via engineering design: the role of mathematical prototyping.
Klinke DJ, Wang Q.
Comput Math Methods Med. 2012;2012:676015


Timescale analysis of rule-based biochemical reaction networks.
Klinke DJ, Finley SD.
Biotechnol Prog. 2012;28(1):33-44.


A quantitative systems approach to identify paracrine mechanisms that locally suppress immune response to Interleukin-12 in the B16 melanoma model.
Kulkarni YM, Chambers E, McGray AJ, Ware JS, Bramson JL, Klinke DJ.
Integr Biol (Camb). 2012;4(8):925-936.


Protein-based identification of quantitative trait loci associated with malignant transformation in two HER2+ cellular models of breast cancer.
Kulkarni YM, Klinke DJ.
Proteome Sci. 2012;10(1):11


Quantitative measurement of invadopodia-mediated extracellular matrix proteolysis in single and multicellular contexts.
Martin KH, Hayes KE, Walk EL, Ammer AG, Markwell SM, Weed SA.
J Vis Exp. 2012;(66):4419


Effects of tobacco smoking and nicotine on cancer treatment.
Petros WP, Younis IR, Ford JN, Weed SA.
Pharmacotherapy. 2012;32(10):920-931.


Two CheW coupling proteins are essential in a chemosensory pathway of Borrelia burgdorferi.
Zhang K, Liu J, Tu Y, Xu H, Charon NW, Li C.
Mol Microbiol. 2012;85(4):782-794.


Multi-photon imaging of tumor cell invasion in an orthotopic mouse model of oral squamous cell carcinoma.
Ammer AG, Hayes KE, Martin KH, Zhang L, Spirou GA, Weed SA.
J Vis Exp. 2011;(53)


miR-190-Mediated downregulation of PHLPP contributes to arsenic-induced Akt activation and carcinogenesis.
Beezhold KJ, Liu J, Kan H, Meighan T, Castranova V, Shi X, Chen F.
Toxicol Sci. 2011;123(2):411-420.


Cadherin-dependent adhesion of human U373MG glioblastoma cells promotes neurite outgrowth and increases migratory capacity. Laboratory investigation.
Cifarelli CP, Titus B, Yeoh HK.
J Neurosurg. 2011;114(3):663-669.

Further insights into cortactin conformational regulation.
Evans JV, Kelley LC, Hayes KE, Ammer AG, Martin KH, Weed SA.
Bioarchitecture. 2011;1(1):21-23.


Inferring relevant control mechanisms for interleukin-12 signaling in naive CD4+ T cells.
Finley SD, Gupta D, Cheng N, Klinke DJ.
Immunol Cell Biol. 2011;89(1):100-110.


The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain.
Gehman LT, Stoilov P, Maguire J, Damianov A, Lin CH, Shiue L, Ares M, Jr., Mody I, Black DL.
Nat Genet. 2011;43(7):706-711.


Subtractive hybridization analysis of gastric diseases-associated Helicobacter pylori identifies peptidyl-prolyl isomerase as a potential marker for gastric cancer.
Gong YH, Chen M, Xu Y, Dong N, Sang Z, Liu J, Yuan Y.
FEMS Microbiol Lett. 2011;320(2):103-109.

Focal adhesion kinase exploring FAK structure to gain insight into function.
Hall JE, Fu W, Schaller MD.
Int Rev Cell Mol Biol. 2011;288:185-225.

Revisiting the ERK/Src cortactin switch.
Kelley LC, Hayes KE, Ammer AG, Martin KH, Weed SA.
Commun Integr Biol. 2011;4(2):205-207.


Age-corrected Beta cell mass following onset of type 1 diabetes mellitus correlates with plasma C-Peptide in humans.
Klinke DJ.
PLoS One. 2011;6(11):e26873


A pathway for the control of anoikis sensitivity by E-cadherin and epithelial-to-mesenchymal transition.
Kumar S, Park SH, Cieply B, Schupp J, Killiam E, Zhang F, Rimm DL, Frisch SM.
Mol Cell Biol. 2011;31(19):4036-4051.


Trans sodium crocetinate: functional neuroimaging studies in a hypoxic brain tumor.
Sheehan JP, Popp B, Monteith SJ, Toulmin S, Tomlinson J, Martin J, Cifarelli CP, Lee DH, Park DM.
J Neurosurg. 2011;115(4):749-753.

Recently identified biomarkers that promote lymph node metastasis in head and neck squamous cell carcinoma.
Walk EL, Weed SA.
Cancers (Basel). 2011;3(1):747-772.


Gamma knife radiosurgery for dural arteriovenous fistulas.
Cifarelli CP, Kaptain G, Yen CP, Schlesinger D, Sheehan JP.
Neurosurgery. 2010;67(5):1230-1235.

PTP-PEST controls motility, adherens junction assembly, and Rho GTPase activity in colon cancer cells.
Espejo R, Rengifo-Cam W, Schaller MD, Evers BM, Sastry SK.
Am J Physiol Cell Physiol. 2010;299(2):C454-C463.


Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence.
Kelley LC, Hayes KE, Ammer AG, Martin KH, Weed SA.
PLoS One. 2010;5(11):e13847


Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation.
Kelley LC, Ammer AG, Hayes KE, Martin KH, Machida K, Jia L, Mayer BJ, Weed SA.
J Cell Sci. 2010;123(pt22):3923-3932.


A multiscale systems perspective on cancer, immunotherapy, and Interleukin-12.
Klinke DJ.
Mol Cancer. 2010;9:242


Signal transduction networks in cancer: quantitative parameters influence network topology.
Klinke DJ.
Cancer Res. 2010;70(5):1773-1782.


Inferring predominant pathways in cellular models of breast cancer using limited sample proteomic profiling.
Kulkarni YM, Suarez V, Klinke DJ.
BMC Cancer. 2010;10:291


Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage.
Mistry PK, Liu J, Yang M, Nottoli T, McGrath J, Jain D, Zhang K, Keutzer J, Chuang WL, Mehal WZ, Zhao H, Lin A, Mane S, Liu X, Peng YZ, Li JH, Agrawal M, Zhu LL, Blair HC, Robinson LJ, Iqbal J, Sun L, Zaidi M.
Proc Natl Acad Sci U S A. 2010;107(45):19473-19478.


PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.
Schaller MD, Frisch SM.
Cancer Biol Ther. 2010;9(10):791-793.

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions.
Schaller MD.
J Cell Sci. 2010;123(Pt 7):1007-1013.

Trans-sodium crocetinate enhancing survival and glioma response on magnetic resonance imaging to radiation and temozolomide.
Sheehan J, Cifarelli CP, Dassoulas K, Olson C, Rainey J, Han S.
J Neurosurg. 2010;113(2):234-239.

Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis.
Sood AK, Armaiz-Pena GN, Halder J, Nick AM, Stone RL, Hu W, Carroll AR, Spannuth WA, Deavers MT, Allen JK, Han LY, Kamat AA, Shahzad MM, McIntyre BW, Diaz-Montero CM, Jennings NB, Lin YG, Merritt WM, DeGeest K, Vivas-Mejia PE, Lopez-Berestein G, Schaller MD, Cole SW, Lutgendorf SK.
J Clin Invest. 2010;120(5):1515-1523.


Cytoskeleton alterations in melanoma: aberrant expression of cortactin, an actin-binding adapter protein, correlates with melanocytic tumor progression.
Xu XZ, Garcia MV, Li TY, Khor LY, Gajapathy RS, Spittle C, Weed SA, Lessin SR, Wu H.
Mod Pathol. 2010;23(2):187-196.


Saracatinib impairs head and neck squamous cell carcinoma invasion by disrupting invadopodia function.
Ammer AG, Kelley LC, Hayes KE, Evans JV, Lopez-Skinner LA, Martin KH, Frederick B, Rothschild BL, Raben D, Elvin P, Green TP, Weed SA.
J Cancer Sci Ther. 2009;1(2):52-61.


Activation of Src kinase by protein-tyrosine phosphatase-PEST in osteoclasts: comparative analysis of the effects of bisphosphonate and protein-tyrosine phosphatase inhibitor on Src activation in vitro.
Chellaiah MA, Schaller MD.
J Cell Physiol. 2009;220(2):382-393.

Validating a dimensionless number for glucose homeostasis in humans.
Klinke DJ.
Ann Biomed Eng. 2009;37(9):1886-1896.

Scalable analysis of flow cytometry data using R/Bioconductor.
Klinke DJ, Brundage KM.
Cytometry A. 2009;75(8):699-706.


An empirical Bayesian approach for model-based inference of cellular signaling networks.
Klinke DJ.
BMC Bioinformatics. 2009;10:371


Identification and classification of bcl genes and proteins of Bacillus cereus group organisms and their application in Bacillus anthracis detection and fingerprinting.
Leski TA, Caswell CC, Pawlowski M, Klinke DJ, Bujnicki JM, Hart SJ, Lukomski S.
Appl Environ Microbiol. 2009;75(22):7163-7172.


Toward a fully de-identified biomedical information warehouse.
Liu J, Erdal S, Silvey SA, Ding J, Riedel JD, Marsh CB, Kamal J.
AMIA Annu Symp Proc. 2009;2009:370-374.


Lipid binding to the tail domain of vinculin: specificity and the role of the N and C termini.
Palmer SM, Playford MP, Craig SW, Schaller MD, Campbell SL.
J Biol Chem. 2009;284(11):7223-7231.


Cortactin is a functional target of E-cadherin-activated Src family kinases in MCF7 epithelial monolayers.
Ren G, Helwani FM, Verma S, McLachlan RW, Weed SA, Yap AS.
J Biol Chem. 2009;284(28):18913-18922.


Effect of trans sodium crocetinate on brain tumor oxygenation. Laboratory investigation.
Sheehan J, Sherman J, Cifarelli CP, Jagannathan J, Dassoulas K, Olson C, Rainey J, Han S.
J Neurosurg. 2009;111(2):226-229.

A conserved sequence in caveolin-1 is both necessary and sufficient for caveolin polarity and cell directional migration.
Sun XH, Liu ZY, Chen H, Beardsley AR, Qi Q, Liu J.
FEBS Lett. 2009;583(22):3681-3689.

Insulin receptor kinase-independent signaling via tyrosine phosphorylation of phosphatase PHLPP1.
Zhang MC, Riedel H.
J Cell Biochem. 2009;107(1):65-75.

Cortactin branches out: roles in regulating protrusive actin dynamics.
Ammer AG, Weed SA.
Cell Motil Cytoskeleton. 2008;65(9):687-707.


Caveolin-1 up-regulation during epithelial to mesenchymal transition is mediated by focal adhesion kinase.
Bailey KM, Liu J.
J Biol Chem. 2008;283(20):13714-13724.


Spatial and temporal regulation of focal adhesion kinase activity in living cells.
Cai X, Lietha D, Ceccarelli DF, Karginov AV, Rajfur Z, Jacobson K, Hahn KM, Eck MJ, Schaller MD.
Mol Cell Biol. 2008;28(1):201-214.


Mitogenic roles of Gab1 and Grb10 as direct cellular partners in the regulation of MAP kinase signaling.
Deng Y, Zhang M, Riedel H.
J Cell Biochem. 2008;105(5):1172-1182.

Phosphorylation of AFAP-110 affects podosome lifespan in A7r5 cells.
Dorfleutner A, Cho YJ, Vincent DM, Cunnick JM, Lin H, Weed SA, Stehlik C, Flynn DC.
J Cell Sci. 2008;121(Pt 14):2394-2405.

Caspase-8: fly or die.
Frisch SM.
Cancer Res. 2008;68(12):4491-4493.

Actin cytoskeletal mediators of motility and invasion amplified and overexpressed in head and neck cancer.
Kelley LC, Shahab S, Weed SA.
Clin Exp Metastasis. 2008;25(4):289-304.

Modulating temporal control of NF-kappaB activation: implications for therapeutic and assay selection.
Klinke DJ, Ustyugova IV, Brundage KM, Barnett JB.
Biophys J. 2008;94(11):4249-4259.


Extent of beta cell destruction is important but insufficient to predict the onset of type 1 diabetes mellitus.
Klinke DJ.
PLoS One. 2008;3(1):e1374


Integrating epidemiological data into a mechanistic model of type 2 diabetes: validating the prevalence of virtual patients.
Klinke DJ.
Ann Biomed Eng. 2008;36(2):321-334.

Bayesian mass spectra peak alignment from mass charge ratios.
Liu J, Yu W, Wu B, Zhao H.
Cancer Inform. 2008;6:217-241.


Vinculin Tail conformation and self-association is independent of pH and H906 protonation.
Palmer SM, Schaller MD, Campbell SL.
Biochemistry. 2008;

Focal adhesion kinase regulates cell-cell contact formation in epithelial cells via modulation of Rho.
Playford MP, Vadali K, Cai X, Burridge K, Schaller MD.
Exp Cell Res. 2008;314(17):3187-3197.


Calcium-dependent Pyk2 activation: a role for calmodulin?
Schaller MD.
Biochem J. 2008;410(3):e3-e4.

Multiple paxillin binding sites regulate FAK function.
Scheswohl DM, Harrell JR, Rajfur Z, Gao G, Campbell SL, Schaller MD.
J Mol Signal. 2008;3:1


A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators.
Stoilov P, Lin CH, Damoiseaux R, Nikolic J, Black DL.
Proc Natl Acad Sci USA. 2008;105(32):11218-11223.


MADS: a new and improved method for analysis of differential alternative splicing by exon-tiling microarrays.
Xing Y, Stoilov P, Kapur K, Han A, Jiang H, Shen S, Black DL, Wong WH.
RNA. 2008;14(8):1470-1479.


PSM/SH2B1 splice variants: critical role in src catalytic activation and the resulting STAT3s-mediated mitogenic response.
Zhang MC, Deng YP, Riedel H.
J Cell Biochem. 2008;104(1):105-118.

Essential role of PSM/SH2-B variants in insulin receptor catalytic activation and the resulting cellular responses.
Zhang MC, Deng YP, Tandon R, Bai C, Riedel H.
J Cell Biochem. 2008;103(1):162-181.

A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons.
Boutz PL, Stoilov P, Li Q, Lin CH, Chawla G, Ostrow K, Shiue L, Ares M, Jr., Black DL.
Genes Dev. 2007;21(13):1636-1652.


MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development.
Boutz PL, Chawla G, Stoilov P, Black DL.
Genes Dev. 2007;21(1):71-84.


PSM/SH2-B distributes selected mitogenic receptor signals to distinct components in the PI3-kinase and MAP kinase signaling pathways.
Deng Y, Xu H, Riedel H.
J Cell Biochem. 2007;100(3):557-573.

Overexpression of caveolin-1 inhibits endothelial cell proliferation by arresting the cell cycle at G0/G1 phase.
Fang K, Fu W, Beardsley AR, Sun X, Lisanti MP, Liu J.
Cell Cycle. 2007;6(2):199-204.

Overexpression of cyclin D1 and cortactin is primarily independent of gene amplification in salivary gland adenoid cystic carcinoma.
Greer RO, Jr., Said S, Shroyer KR, Marileila VG, Weed SA.
Oral Oncol. 2007;43(8):735-741.

Blockade of tumor necrosis factor-induced Bid cleavage by caspase-resistant Rb.
Huang X, Masselli A, Frisch SM, Hunton IC, Jiang Y, Wang JY.
J Biol Chem. 2007;282(40):29401-29413.

A multi-scale model of dendritic cell education and trafficking in the lung: implications for T cell polarization.
Klinke DJ.
Ann Biomed Eng. 2007;35(6):937-955.

Structural basis for the autoinhibition of focal adhesion kinase.
Lietha D, Cai X, Ceccarelli DF, Li Y, Schaller MD, Eck MJ.
Cell. 2007;129(6):1177-1187.


Caspase-8 interacts with the p85 subunit of phosphatidylinositol 3-kinase to regulate cell adhesion and motility.
Senft J, Helfer B, Frisch SM.
Cancer Res. 2007;67(24):11505-11509.

Identification of a novel domain at the N terminus of caveolin-1 that controls rear polarization of the protein and caveolae formation.
Sun XH, Flynn DC, Castranova V, Millecchia LL, Beardsley AR, Liu J.
J Biol Chem. 2007;282(10):7232-7241.

Src phosphorylation of cortactin enhances actin assembly.
Tehrani S, Tomasevic N, Weed SA, Sakowicz R, Cooper JA.
Proc Natl Acad Sci USA. 2007;104(29):11933-11938.


Focal adhesion kinase: an essential kinase in the regulation of cardiovascular functions.
Vadali K, Cai X, Schaller MD.
IUBMB Life. 2007;59(11):709-716.

PI3K activation is required for PMA-directed activation of cSrc by AFAP-110.
Walker VG, Ammer AG, Cao Z, Clump AC, Jiang BH, Kelley LC, Weed SA, Zot HM, Flynn DC.
Am J Physiol Cell Physiol. 2007;293(1):C119-C132.

CIB1 regulates endothelial cells and ischemia-induced pathological and adaptive angiogenesis.
Zayed MA, Yuan W, Leisner TM, Chalothorn D, McFadden AW, Schaller MD, Hartnett ME, Faber JE, Parise LV.
Circ Res. 2007;101(11):1185-1193.

The G12/13-RhoA signaling pathway contributes to efficient lysophosphatidic acid-stimulated cell migration.
Bian D, Mahanivong C, Yu J, Frisch SM, Pan ZK, Ye RD, Huang S.
Oncogene. 2006;25(15):2234-2244.

Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement.
Cai X, Li M, Vrana J, Schaller MD.
Mol Cell Biol. 2006;26(7):2857-2868.


Crystal structure of the FERM domain of focal adhesion kinase.
Ceccarelli DF, Song HK, Poy F, Schaller MD, Eck MJ.
J Biol Chem. 2006;281(1):252-259.

Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions.
Helfer B, Boswell BC, Finlay D, Cipres A, Vuori K, Bong KT, Wallach D, Dorfleutner A, Lahti JM, Flynn DC, Frisch SM.
Cancer Res. 2006;66(8):4273-4278.

The ratio of P40 monomer to dimer is an important determinant of IL-12 bioactivity.
Klinke DJ.
J Theor Biol. 2006;240(2):323-335.

An age-structured model of dendritic cell trafficking in the lung.
Klinke DJ.
Am J Physiol Lung Cell Mol Physiol. 2006;291(5):L1038-L1049.

Identification of a filamin docking site on PTP-PEST.
Playford MP, Lyons PD, Sastry SK, Schaller MD.
J Biol Chem. 2006;281(45):34104-34112.

Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification.
Rothschild BL, Shim AH, Ammer AG, Kelley LC, Irby KB, Head JA, Chen L, Varella-Garcia M, Sacks PG, Frederick B, Raben D, Weed SA.
Cancer Res. 2006;66(16):8017-8025.

Loss of caveolin-1 polarity impedes endothelial cell polarization and directional movement.
Beardsley AR, Fang K, Mertz H, Castranova V, Friend S, Liu J.
J Biol Chem. 2005;280(5):3541-3547.

Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.
Cai L, Holoweckyj N, Schaller MD, Bear JE.
J Biol Chem. 2005;280(36):31913-31923.

Focal adhesion kinase silencing augments docetaxel-mediated apoptosis in ovarian cancer cells.
Halder J, Landen CN, Jr., Lutgendorf SK, Li Y, Jennings NB, Fan D, Nelkin GM, Schmandt R, Schaller MD, Sood AK.
Clin Cancer Res. 2005;11(24 Pt 1):8829-8836.

Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activities.
Horner TJ, Osawa S, Schaller MD, Weiss ER.
J Biol Chem. 2005;280(31):28241-28250.

In situ photoactivation of a caged phosphotyrosine peptide derived from focal adhesion kinase temporarily halts lamellar extension of single migrating tumor cells.
Humphrey D, Rajfur Z, Vazquez ME, Scheswohl DM, Schaller MD, Jacobson K, Imperiali B.
J Biol Chem. 2005;280(23):22091-22101.

Measurement of protein tyrosine phosphorylation in cell adhesion.
Iyer VV, Ballestrem C, Kirchner J, Geiger B, Schaller MD.
Methods Mol Biol. 2005;294:289-302.

Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals.
Underwood JG, Boutz PL, Dougherty JD, Stoilov P, Black DL.
Mol Cell Biol. 2005;25(22):10005-10016.


A consensus CaMK IV-responsive RNA sequence mediates regulation of alternative exons in neurons.
Xie J, Jan C, Stoilov P, Park J, Black DL.
RNA. 2005;11(12):1825-1834.


Rac2D57N, a dominant inhibitory Rac2 mutant that inhibits p38 kinase signaling and prevents surface ruffling in bone-marrow-derived macrophages.
Abell AN, DeCathelineau AM, Weed SA, Ambruso DR, Riches DW, Johnson GL.
J Cell Sci. 2004;117(Pt 2):243-255.

Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells.
Bougneres L, Girardin SE, Weed SA, Karginov AV, Olivo-Marin JC, Parsons JT, Sansonetti PJ, Van Nhieu GT.
J Cell Biol. 2004;166(2):225-235.


New insights into FAK signaling and localization based on detection of a FAT domain folding intermediate.
Dixon RD, Chen Y, Ding F, Khare SD, Prutzman KC, Schaller MD, Campbell SL, Dokholyan NV.
Structure. 2004;12(12):2161-2171.

FERM domain interaction promotes FAK signaling.
Dunty JM, Gabarra-Niecko V, King ML, Ceccarelli DF, Eck MJ, Schaller MD.
Mol Cell Biol. 2004;24(12):5353-5368.


Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase.
Fan L, Di Ciano-Oliveira C, Weed SA, Craig AW, Greer PA, Rotstein OD, Kapus A.
Biochem J. 2004;380(Pt 2):581-591.


Nuclear localization of FADD protein.
Frisch SM.
Cell Death Differ. 2004;11(12):1361-1362.

E1A as a tumor suppressor gene: commentary re S. Madhusudan et al. A multicenter Phase I gene therapy clinical trial involving intraperitoneal administration of E1A-lipid complex in patients with recurrent epithelial ovarian cancer overexpressing HER-2/neu oncogene.
Frisch SM.
Clin Cancer Res. 2004;10(9):2905-2907.

NMR solution structure of the focal adhesion targeting domain of focal adhesion kinase in complex with a paxillin LD peptide: evidence for a two-site binding model.
Gao G, Prutzman KC, King ML, Scheswohl DM, DeRose EF, London RE, Schaller MD, Campbell SL.
J Biol Chem. 2004;279(9):8441-8451.

Protein kinase Calpha activates c-Src and induces podosome formation via AFAP-110.
Gatesman AS, Walker VG, Baisden JM, Weed SA, Flynn DC.
Mol Cell Biol. 2004;24(17):7578-7597.


Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization.
Helwani FM, Kovacs EM, Paterson AD, Verma S, Ali RG, Fanning AS, Weed SA, Yap AS.
J Cell Biol. 2004;164(6):899-910.


A role for JNK-paxillin signaling in cell migration.
Huang C, Jacobson K, Schaller MD.
Cell Cycle. 2004;3(1):4-6.

Phosphorylation of paxillin by p38MAPK is involved in the neurite extension of PC-12 cells.
Huang C, Borchers CH, Schaller MD, Jacobson K.
J Cell Biol. 2004;164(4):593-602.


MAP kinases and cell migration.
Huang C, Jacobson K, Schaller MD.
J Cell Sci. 2004;117(Pt 20):4619-4628.

Grb10: more than a simple adaptor protein.
Lim MA, Riedel H, Liu F.
Front Biosci. 2004;9:387-403.

The effect of reciprocal active site mutations in human cytochromes P450 1A1 and 1A2 on alkoxyresorufin metabolism.
Liu J, Ericksen SS, Sivaneri M, Besspiata D, Fisher CW, Szklarz GD.
Arch Biochem Biophys. 2004;424(1):33-43.

Characterization of an ankyrin repeat-containing Shank2 isoform (Shank2E) in liver epithelial cells.
McWilliams RR, Gidey E, Fouassier L, Weed SA, Doctor RB.
Biochem J. 2004;380(Pt 1):181-191.


The interplay between Src and integrins in normal and tumor biology.
Playford MP, Schaller MD.
Oncogene. 2004;23(48):7928-7946.

The focal adhesion targeting domain of focal adhesion kinase contains a hinge region that modulates tyrosine 926 phosphorylation.
Prutzman KC, Gao G, King ML, Iyer VV, Mueller GA, Schaller MD, Campbell SL.
Structure. 2004;12(5):881-891.

Grb10 exceeding the boundaries of a common signaling adapter.
Riedel H.
Front Biosci. 2004;9:603-618.

FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?
Schaller MD.
J Cell Biol. 2004;166(2):157-159.


Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion.
Sood AK, Coffin JE, Schneider GB, Fletcher MS, DeYoung BR, Gruman LM, Gershenson DM, Schaller MD, Hendrix MJ.
Am J Pathol. 2004;165(4):1087-1095.


Human tra2-beta1 autoregulates its protein concentration by influencing alternative splicing of its pre-mRNA.
Stoilov P, Daoud R, Nayler O, Stamm S.
Hum Mol Genet. 2004;13(5):509-524.

A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src.
Carragher NO, Westhoff MA, Fincham VJ, Schaller MD, Frame MC.
Curr Biol. 2003;13(16):1442-1450.

MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts.
Cuevas BD, Abell AN, Witowsky JA, Yujiri T, Johnson NL, Kesavan K, Ware M, Jones PL, Weed SA, DeBiasi RL, Oka Y, Tyler KL, Johnson GL.
EMBO J. 2003;22(13):3346-3355.


Transient mechanoactivation of neutral sphingomyelinase in caveolae to generate ceramide.
Czarny M, Liu J, Oh P, Schnitzer JE.
J Biol Chem. 2003;278(7):4424-4430.

Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action.
Deng Y, Bhattacharya S, Swamy OR, Tandon R, Wang Y, Janda R, Riedel H.
J Biol Chem. 2003;278(41):39311-39322.

FAK regulates biological processes important for the pathogenesis of cancer.
Gabarra-Niecko V, Schaller MD, Dunty JM.
Cancer Metastasis Rev. 2003;22(4):359-374.

C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs.
Grooteclaes ML, Deveraux Q, Hildebrand J, Zhang Q, Goodman RH, Frisch SM.
Proc Natl Acad Sci USA. 2003;100(8):4568-4573.


Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton.
Head JA, Jiang D, Li M, Zorn LJ, Schaefer EM, Parsons JT, Weed SA.
Mol Biol Cell. 2003;14(8):3216-3229.


JNK phosphorylates paxillin and regulates cell migration.
Huang C, Rajfur Z, Borchers CH, Schaller MD, Jacobson K.
Nature. 2003;424(6945):219-223.

Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion.
Kinley AW, Weed SA, Weaver AM, Karginov AV, Bissonette E, Cooper JA, Parsons JT.
Curr Biol. 2003;13(5):384-393.

Inhibition of protein kinase C catalytic activity by additional regions within the human protein kinase Calpha-regulatory domain lying outside of the pseudosubstrate sequence.
Kirwan AF, Bibby AC, Mvilongo T, Riedel H, Burke T, Millis SZ, Parissenti AM.
Biochem J. 2003;373(Pt 2):571-581.


Tyrosine phosphorylation of type Igamma phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch.
Ling K, Doughman RL, Iyer VV, Firestone AJ, Bairstow SF, Mosher DF, Schaller MD, Anderson RA.
J Cell Biol. 2003;163(6):1339-1349.


Characterization of substrate binding to cytochrome P450 1A1 using molecular modeling and kinetic analyses: case of residue 382.
Liu J, Ericksen SS, Besspiata D, Fisher CW, Szklarz GD.
Drub Metab Dispos. 2003;31(4):412-420.

Yeast as a host to screen for modulators and regulatory regions of mammalian protein kinase C isoforms.
Parissenti AM, Riedel H.
Methods Mol Biol. 2003;233:491-516.

Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis.
Screaton RA, Kiessling S, Sansom OJ, Millar CB, Maddison K, Bird A, Clarke AR, Frisch SM.
Proc Natl Acad Sci USA. 2003;100(9):5211-5216.


Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP.
Zhang Q, Yoshimatsu Y, Hildebrand J, Frisch SM, Goodman RH.
Cell. 2003;115(2):177-186.

The N termini of focal adhesion kinase family members regulate substrate phosphorylation, localization, and cell morphology.
Dunty JM, Schaller MD.
J Biol Chem. 2002;277(47):45644-45654.

Adenovirus-5 E1A: paradox and paradigm.
Frisch SM, Mymryk JS.
Nat Rev Mol Cell Biol. 2002;3(6):441-452.

Characterization of an activated mutant of focal adhesion kinase: 'SuperFAK'.
Gabarra-Niecko V, Keely PJ, Schaller MD.
Biochem J. 2002;365(Pt 3):591-603.


Regulation of TRKB surface expression by brain-derived neurotrophic factor and truncated TRKB isoforms.
Haapasalo A, Sipola I, Larsson K, Akerman KE, Stoilov P, Stamm S, Wong G, Castren E.
J Biol Chem. 2002;277(45):43160-43167.

Caveolin-1 expression enhances endothelial capillary tubule formation.
Liu J, Wang XB, Park DS, Lisanti MP.
J Biol Chem. 2002;277(12):10661-10668.

PTP-PEST controls motility through regulation of Rac1.
Sastry SK, Lyons PD, Schaller MD, Burridge K.
J Cell Sci. 2002;115(Pt 22):4305-4316.

Dynamin2 and cortactin regulate actin assembly and filament organization.
Schafer DA, Weed SA, Binns D, Karginov AV, Parsons JT, Cooper JA.
Curr Biol. 2002;12(21):1852-1857.

Analysis of the human TrkB gene genomic organization reveals novel TrkB isoforms, unusual gene length, and splicing mechanism.
Stoilov P, Castren E, Stamm S.
Biochem Biophys Res Commun. 2002;290(3):1054-1065.

YTH: a new domain in nuclear proteins.
Stoilov P, Rafalska I, Stamm S.
Trends Biochem Sci. 2002;27(10):495-497.

Defects in pre-mRNA processing as causes of and predisposition to diseases.
Stoilov P, Meshorer E, Gencheva M, Glick D, Soreq H, Stamm S.
DNA Cell Biol. 2002;21(11):803-818.

Anoikis mechanisms.
Frisch SM, Screaton RA.
Curr Opin Cell Biol. 2001;13(5):555-562.

Tumor suppression activity of adenovirus E1a protein: anoikis and the epithelial phenotype.
Frisch SM.
Adv Cancer Res. 2001;80:39-49.

Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism.
Galbiati F, Volonte D, Liu J, Capozza F, Frank PG, Zhu L, Pestell RG, Lisanti MP.
Mol Biol Cell. 2001;12(8):2229-2244.


Caveolin-1 expression sensitizes fibroblastic and epithelial cells to apoptotic stimulation.
Liu J, Lee P, Galbiati F, Kitsis RN, Lisanti MP.
Am J Physiol Cell Physiol. 2001;280(4):C823-C835.

Inhibition of the catalytic activity of cell adhesion kinase beta by protein-tyrosine phosphatase-PEST-mediated dephosphorylation.
Lyons PD, Dunty JM, Schaefer EM, Schaller MD.
J Biol Chem. 2001;276(26):24422-24431.

Caveolin-1, a putative tumour suppressor gene.
Razani B, Schlegel A, Liu J, Lisanti MP.
Biochem Soc Trans. 2001;29(Pt 4):494-499.

Multiple stimuli induce tyrosine phosphorylation of the Crk-binding sites of paxillin.
Schaller MD, Schaefer EM.
Biochem J. 2001;360(Pt 1):57-66.


Biochemical signals and biological responses elicited by the focal adhesion kinase.
Schaller MD.
Biochim Biophys Acta. 2001;1540(1):1-21.

Paxillin: a focal adhesion-associated adaptor protein.
Schaller MD.
Oncogene. 2001;20(44):6459-6472.

Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation.
Weaver AM, Karginov AV, Kinley AW, Weed SA, Li Y, Parsons JT, Cooper JA.
Curr Biol. 2001;11(5):370-374.

Cortactin: coupling membrane dynamics to cortical actin assembly.
Weed SA, Parsons JT.
Oncogene. 2001;20(44):6418-6434.

Four PSM/SH2-B alternative splice variants and their differential roles in mitogenesis.
Yousaf N, Deng Y, Kang Y, Riedel H.
J Biol Chem. 2001;276(44):40940-40948.

Dynamic molecular modeling of pathogenic mutations in the spectrin self-association domain.
Zhang Z, Weed SA, Gallagher PG, Morrow JS.
Blood. 2001;98(6):1645-1653.

Regulation of c-SRC activity and function by the adapter protein CAS.
Burnham MR, Bruce-Staskal PJ, Harte MT, Weidow CL, Ma A, Weed SA, Bouton AH.
Mol Cell Biol. 2000;20(16):5865-5878.


Paxillin binding is not the sole determinant of focal adhesion localization or dominant-negative activity of focal adhesion kinase/focal adhesion kinase-related nonkinase.
Cooley MA, Broome JM, Ohngemach C, Romer LH, Schaller MD.
Mol Biol Cell. 2000;11(9):3247-3263.


Frisch SM.
Methods Enzymol. 2000;322:472-479.

cAMP takes control.
Frisch SM.
Nat Cell Biol. 2000;2(9):E167-E168.

Evidence for a function of CtBP in epithelial gene regulation and anoikis.
Grooteclaes ML, Frisch SM.
Oncogene. 2000;19(33):3823-3828.

Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement.
Parsons JT, Martin KH, Slack JK, Taylor JM, Weed SA.
Oncogene. 2000;19(49):5606-5613.

PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis.
Riedel H, Yousaf N, Zhao Y, Dai H, Deng Y, Wang J.
Oncogene. 2000;19(1):39-50.

UNC112. A new regulator of cell-extracellular matrix adhesions?
Schaller MD.
J Cell Biol. 2000;150(1):F9-F11.


The noncatalytic domain of protein-tyrosine phosphatase-PEST targets paxillin for dephosphorylation in vivo.
Shen Y, Lyons PD, Cooley MA, Davidson D, Veillette A, Salgia R, Griffin JD, Schaller MD.
J Biol Chem. 2000;275(2):1405-1413.

An alternative-exon database and its statistical analysis.
Stamm S, Zhu J, Nakai K, Stoilov P, Stoss O, Zhang MQ.
DNA Cell Biol. 2000;19(12):739-756.

Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex.
Weed SA, Karginov AV, Schafer DA, Weaver AM, Kinley AW, Cooper JA, Parsons JT.
J Cell Biol. 2000;151(1):29-40.


Methods for studying anoikis.
Frisch SM.
Methods Mol Biol. 1999;129:251-256.

Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis.
Frisch SM.
Curr Biol. 1999;9(18):1047-1049.

Construction of a mechanistic model of Fischer-Tropsch synthesis on Ni(111) and Co(0001) surfaces.
Klinke DJ, Broadbelt LJ.
Chem Eng Sci. 1999;54(15-16):3379-3389.

A theoretical study of hydrogen chemisorption on Ni(111) and Co(0001) surfaces.
Klinke DJ, Broadbelt LJ.
Surface Science. 1999;429(1-3):169-177.

A theoretical study of methylidyne chemisorption on Ni(111)and Co(0001)surfaces.
Klinke DJ, Dooling DJ, Broadbelt LJ.
Surface Science. 1999;425(2-3):334-342.

Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells. Angiogenesis inhibitors block vascular endothelial growth factor-induced down-regulation of caveolin-1.
Liu J, Razani B, Tang S, Terman BI, Ware JA, Lisanti MP.
J Biol Chem. 1999;274(22):15781-15785.

Complex formation with focal adhesion kinase: a mechanism to regulate activity and subcellular localization of Src kinases.
Schaller MD, Hildebrand JD, Parsons JT.
Mol Biol Cell. 1999;10(10):3489-3505.


NCAM stimulates the Ras-MAPK pathway and CREB phosphorylation in neuronal cells.
Schmid RS, Graff RD, Schaller MD, Chen SL, Schachner M, Hemperly JJ, Maness PF.
J Neurobiol. 1999;38(4):542-558.

Focal adhesion targeting: the critical determinant of FAK regulation and substrate phosphorylation.
Shen Y, Schaller MD.
Mol Biol Cell. 1999;10(8):2507-2518.


The in vivo minigene approach to analyze tissue-specific splicing.
Stoss O, Stoilov P, Hartmann AM, Nayler O, Stamm S.
Brain Res Brain Res Protoc. 1999;4(3):383-394.

The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillin.
Thomas JW, Cooley MA, Broome JM, Salgia R, Griffin JD, Lombardo CR, Schaller MD.
J Biol Chem. 1999;274(51):36684-36692.

Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis.
Wang J, Dai H, Yousaf N, Moussaif M, Deng Y, Boufelliga A, Swamy OR, Leone ME, Riedel H.
Mol Cell Biol. 1999;19(9):6217-6228.


IRS pleckstrin homology domains bind to acidic motifs in proteins.
Burks DJ, Wang J, Towery H, Ishibashi O, Lowe D, Riedel H, White MF.
J Biol Chem. 1998;273(47):31061-31067.

Regulation of cell death protease caspase-9 by phosphorylation.
Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch SM, Reed JC.
Science. 1998;282(5392):1318-1321.

Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons.
Du Y, Weed SA, Xiong WC, Marshall TD, Parsons JT.
Mol Cell Biol. 1998;18(10):5838-5851.


A theoretical study of carbon chemisorption on Ni(111) and Co(0001) surfaces.
Klinke DJ, Wilke S, Broadbelt LJ.
J Catal. 1998;178(2):540-554.

Deletion analysis of protein kinase Calpha reveals a novel regulatory segment.
Rotenberg SA, Zhu J, Hansen H, Li XD, Sun XG, Michels CA, Riedel H.
J Biochem. 1998;124(4):756-763.

Direct association of protein-tyrosine phosphatase PTP-PEST with paxillin.
Shen Y, Schneider GB, Cloutier JF, Veillette A, Schaller MD.
J Biol Chem. 1998;273(11):6474-6481.

Modulation of rat rotational behavior by direct gene transfer of constitutively active protein kinase C into nigrostriatal neurons.
Song S, Wang Y, Bak SY, During MJ, Bryan J, Ashe O, Ullrey DB, Trask LE, Grant FD, O'Malley KL, Riedel H, Goldstein DS, Neve KA, LaHoste GJ, Marshall JF, Haycock JW, Neve RL, Geller AI.
J Neurosci. 1998;18(11):4119-4132.

SH2- and SH3-mediated interactions between focal adhesion kinase and Src.
Thomas JW, Ellis B, Boerner RJ, Knight WB, White GC, Schaller MD.
J Biol Chem. 1998;273(1):577-583.

Insulin-like growth factor-I receptor and insulin receptor association with a Src homology-2 domain-containing putative adapter.
Wang J, Riedel H.
J Biol Chem. 1998;273(6):3136-3139.

Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1.
Weed SA, Du Y, Parsons JT.
J Cell Sci. 1998;111 ( Pt 16):2433-2443.

The regulation of anoikis: MEKK-1 activation requires cleavage by caspases.
Cardone MH, Salvesen GS, Widmann C, Johnson G, Frisch SM.
Cell. 1997;90(2):315-323.

Repair pattern in the beta-globin gene cluster of human fibroblasts after ultraviolet irradiation.
Chakarov S, Stoilov P, Alexandrov A, Russev G.
Eur J Biochem. 1997;248(3):669-675.

Integrins and anoikis.
Frisch SM, Ruoslahti E.
Curr Opin Cell Biol. 1997;9(5):701-706.

The epithelial cell default-phenotype hypothesis and its implications for cancer.
Frisch SM.
Bioessays. 1997;19(8):705-709.

Mutation of a highly conserved residue of betaI spectrin associated with fatal and near-fatal neonatal hemolytic anemia.
Gallagher PG, Petruzzi MJ, Weed SA, Zhang Z, Marchesi SL, Mohandas N, Morrow JS, Forget BG.
J Clin Invest. 1997;99(2):267-277.


Mechanism reduction during computer generation of compact reaction models.
Klinke DJ, Broadbelt LJ.
Aiche Journal. 1997;43(7):1828-1837.

The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts.
Laviola L, Giorgino F, Chow JC, Baquero JA, Hansen H, Ooi J, Zhu J, Riedel H, Smith RJ.
J Clin Invest. 1997;99(5):830-837.


Organized endothelial cell surface signal transduction in caveolae distinct from glycosylphosphatidylinositol-anchored protein microdomains.
Liu J, Oh P, Horner T, Rogers RA, Schnitzer JE.
J Biol Chem. 1997;272(11):7211-7222.

PSM, an insulin-dependent, pro-rich, PH, SH2 domain containing partner of the insulin receptor.
Riedel H, Wang J, Hansen H, Yousaf N.
J Biochem. 1997;122(6):1105-1113.

Signaling through the focal adhesion kinase.
Schaller MD.
Soc Gen Physiol Ser. 1997;52:241-255.

Differential signaling by the focal adhesion kinase and cell adhesion kinase beta.
Schaller MD, Sasaki T.
J Biol Chem. 1997;272(40):25319-25325.

Control of adhesion-dependent cell survival by focal adhesion kinase.
Frisch SM, Vuori K, Ruoslahti E, Chan-Hui PY.
J Cell Biol. 1996;134(3):793-799.


Reversal of malignancy by the adenovirus E1a gene.
Frisch SM.
Mutat Res. 1996;350(1):261-266.

A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA.
Frisch SM, Vuori K, Kelaita D, Sicks S.
J Cell Biol. 1996;135(5):1377-1382.


Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus.
Hansen H, Svensson U, Zhu J, Laviola L, Giorgino F, Wolf G, Smith RJ, Riedel H.
J Biol Chem. 1996;271(15):8882-8886.

Expression of the integrin alpha 5 subunit in HT29 colon carcinoma cells suppresses apoptosis triggered by serum deprivation.
O'Brien V, Frisch SM, Juliano RL.
Exp Cell Res. 1996;224(1):208-213.

The focal adhesion kinase.
Schaller MD.
J Endocrinol. 1996;150(1):1-7.

Activation of conventional mammalian protein kinase C isoforms expressed in budding yeast modulates the cell doubling time--a potential in vivo screen for protein kinase C activators.
Shieh HL, Hansen H, Zhu J, Riedel H.
Cancer Detect Prev. 1996;20(6):576-589.

Repression of a matrix metalloprotease gene by E1A correlates with its ability to bind to cell type-specific transcription factor AP-2.
Somasundaram K, Jayaraman G, Williams T, Moran E, Frisch SM, Thimmapaya B.
Proc Natl Acad Sci USA. 1996;93(7):3088-3093.


The lethal hemolytic mutation in beta I sigma 2 spectrin Providence yields a null phenotype in neonatal skeletal muscle.
Weed SA, Stabach PR, Oyer CE, Gallagher PG, Morrow JS.
Lab Invest. 1996;74(6):1117-1129.

Interaction of focal adhesion kinase with cytoskeletal protein talin.
Chen HC, Appeddu PA, Parsons JT, Hildebrand JD, Schaller MD, Guan JL.
J Biol Chem. 1995;270(28):16995-16999.

E1A--oncogene or tumor suppressor?
Frisch SM.
Bioessays. 1995;17(11):1002

Adenovirus E1A-mediated tumor suppression by a c-erbB-2/neu-independent mechanism.
Frisch SM, Dolter KE.
Cancer Res. 1995;55(23):5551-5555.

Recurrent fatal hydrops fetalis associated with a nucleotide substitution in the erythrocyte beta-spectrin gene.
Gallagher PG, Weed SA, Tse WW, Benoit L, Morrow JS, Marchesi SL, Mohandas N, Forget BG.
J Clin Invest. 1995;95(3):1174-1182.


Simian virus 40 transformation alters the actin cytoskeleton, expression of matrix metalloproteinases and inhibitors of metalloproteinases, and invasive behavior of normal and ataxia-telangiectasia human skin fibroblasts.
Hansell EJ, Frisch SM, Tremble P, Murnane JP, Werb Z.
Biochem Cell Biol. 1995;73(7-8):373-389.

Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo.
Hennig G, Behrens J, Truss M, Frisch SM, Reichmann E, Birchmeier W.
Oncogene. 1995;11(3):475-484.

Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase.
Hildebrand JD, Schaller MD, Parsons JT.
Mol Biol Cell. 1995;6(6):637-647.


Deletion analysis of protein kinase C inactivation by calphostin C.
Rotenberg SA, Huang MH, Zhu J, Su L, Riedel H.
Mol Carcinog. 1995;12(1):42-49.

pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk.
Schaller MD, Parsons JT.
Mol Cell Biol. 1995;15(5):2635-2645.


Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.
Schaller MD, Otey CA, Hildebrand JD, Parsons JT.
J Cell Biol. 1995;130(5):1181-1187.


Separation of caveolae from associated microdomains of GPI-anchored proteins.
Schnitzer JE, McIntosh DP, Dvorak AM, Liu J, Oh P.
Science. 1995;269(5229):1435-1439.

Endothelial caveolae have the molecular transport machinery for vesicle budding, docking, and fusion including VAMP, NSF, SNAP, annexins, and GTPases.
Schnitzer JE, Liu J, Oh P.
J Biol Chem. 1995;270(24):14399-14404.

Differential protein kinase C ligand regulation detected in vivo by a phenotypic yeast assay.
Shieh HL, Hansen H, Zhu J, Riedel H.
Mol Carcinog. 1995;12(3):166-176.

Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.
Cobb BS, Schaller MD, Leu TH, Parsons JT.
Mol Cell Biol. 1994;14(1):147-155.


E1a induces the expression of epithelial characteristics.
Frisch SM.
J Cell Biol. 1994;127(4):1085-1096.


Disruption of epithelial cell-matrix interactions induces apoptosis.
Frisch SM, Francis H.
J Cell Biol. 1994;124(4):619-626.


Bacterial lipopolysaccharide has structural similarity to ceramide and stimulates ceramide-activated protein kinase in myeloid cells.
Joseph CK, Wright SD, Bornmann WG, Randolph JT, Kumar ER, Bittman R, Liu J, Kolesnick RN.
J Biol Chem. 1994;269(26):17606-17610.

A partial structural repeat forms the heterodimer self-association site of all beta-spectrins.
Kennedy SP, Weed SA, Forget BG, Morrow JS.
J Biol Chem. 1994;269(15):11400-11408.

Renaturation and tumor necrosis factor-alpha stimulation of a 97-kDa ceramide-activated protein kinase.
Liu J, Mathias S, Yang Z, Kolesnick RN.
J Biol Chem. 1994;269(4):3047-3052.

Beta II-spectrin (fodrin) and beta I epsilon 2-spectrin (muscle) contain NH2- and COOH-terminal membrane association domains (MAD1 and MAD2).
Lombardo CR, Weed SA, Kennedy SP, Forget BG, Morrow JS.
J Biol Chem. 1994;269(46):29212-29219.

SH2 domain specificity and activity modified by a single residue.
Marengere LE, Songyang Z, Gish GD, Schaller MD, Parsons JT, Stern MJ, Cantley LC, Pawson T.
Nature. 1994;369(6480):502-505.

Focal adhesion kinase: structure and signalling.
Parsons JT, Schaller MD, Hildebrand J, Leu TH, Richardson A, Otey CA.
J Cell Sci Suppl. 1994;18:109-113.

Epidermal growth factor (EGF) modulation of feline sarcoma virus fms tyrosine kinase activity, internalization, degradation, and transforming potential in an EGF receptor/v-fms chimera.
Riedel H.
J Virol. 1994;68(1):411-424.


Focal adhesion kinase and associated proteins.
Schaller MD, Parsons JT.
Curr Opin Cell Biol. 1994;6(5):705-710.

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src.
Schaller MD, Hildebrand JD, Shannon JD, Fox JW, Vines RR, Parsons JT.
Mol Cell Biol. 1994;14(3):1680-1688.


Ligand regulation of bovine protein kinase C alpha response via either cysteine-rich repeat of conserved region C1.
Zhu J, Hansen H, Su L, Shieh HL, Riedel H.
J Biochem. 1994;115(5):1000-1009.

Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions.
Hildebrand JD, Schaller MD, Parsons JT.
J Cell Biol. 1993;123(4):993-1005.


Reconstitution of protein kinase C alpha function by the protein kinase C beta-I carboxy terminus.
Parissenti AM, Su L, Riedel H.
Mol Cell Endocrinol. 1993;98(1):9-16.

Stimulation of calcium uptake in Saccharomyces cerevisiae by bovine protein kinase C alpha.
Riedel H, Parissenti AM, Hansen H, Su L, Shieh HL.
J Biol Chem. 1993;268(5):3456-3462.

Phorbol ester activation of functional rat protein kinase C beta-1 causes phenotype in yeast.
Riedel H, Hansen H, Parissenti AM, Su L, Shieh HL, Zhu J.
J Cell Biochem. 1993;52(3):320-329.

Yeast phenotype classifies mammalian protein kinase C cDNA mutants.
Riedel H, Su L, Hansen H.
Mol Cell Biol. 1993;13(8):4728-4735.


Focal adhesion kinase: an integrin-linked protein tyrosine kinase.
Schaller MD, Parsons JT.
Trends Cell Biol. 1993;3(8):258-262.

Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK.
Schaller MD, Borgman CA, Parsons JT.
Mol Cell Biol. 1993;13(2):785-791.


Identification and characterization of novel substrates for protein tyrosine kinases.
Schaller MD, Bouton AH, Flynn DC, Parsons JT.
Prog Nucleic Acid Res Mol Biol. 1993;44:205-227.

Functional carboxyl terminal deletion map of protein kinase C alpha.
Su L, Parissenti AM, Riedel H.
Receptors Channels. 1993;1(1):1-9.

Tyrosine phosphorylation of the focal adhesion kinase pp125FAK during development: relation to paxillin.
Turner CE, Schaller MD, Parsons JT.
J Cell Sci. 1993;105 ( Pt 3):637-645.

Tyrosine phosphorylation of a 120,000 dalton membrane-associated protein by the neural form of pp60c-src, pp60c-src+.
Flynn DC, Schaller MD, Parsons JT.
Oncogene. 1992;7(3):579-583.

Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets.
Lipfert L, Haimovich B, Schaller MD, Cobb BS, Parsons JT, Brugge JS.
J Cell Biol. 1992;119(4):905-912.


Enhancement of noradrenaline-induced inositol polyphosphate formation by glucocorticoids in rat vascular smooth muscle cells.
Liu J, Haigh RM, Jones CT.
J Endocrinol. 1992;133(3):405-411.

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.
Schaller MD, Borgman CA, Cobb BS, Vines RR, Reynolds AB, Parsons JT.
Proc Natl Acad Sci USA. 1992;89(11):5192-5196.


Antioncogenic effect of adenovirus E1A in human tumor cells.
Frisch SM.
Proc Natl Acad Sci USA. 1991;88(20):9077-9081.


Positive and negative transcriptional elements of the human type IV collagenase gene.
Frisch SM, Morisaki JH.
Mol Cell Biol. 1990;10(12):6524-6532.


Adenovirus E1A represses protease gene expression and inhibits metastasis of human tumor cells.
Frisch SM, Reich R, Collier IE, Genrich LT, Martin G, Goldberg GI.
Oncogene. 1990;5(1):75-83.

Secreted proteases. Regulation of their activity and their possible role in metastasis.
Goldberg GI, Frisch SM, He C, Wilhelm SM, Reich R, Collier IE.
Ann NY Acad Sci. 1990;580:375-384.

Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors.
Riedel H, Dull TJ, Honegger AM, Schlessinger J, Ullrich A.
EMBO J. 1989;8(10):2943-2954.


Ligand activation of overexpressed epidermal growth factor receptors transforms NIH 3T3 mouse fibroblasts.
Riedel H, Massoglia S, Schlessinger J, Ullrich A.
Proc Natl Acad Sci USA. 1988;85(5):1477-1481.


Transcription from the stromelysin promoter is induced by interleukin-1 and repressed by dexamethasone.
Frisch SM, Ruley HE.
J Biol Chem. 1987;262(34):16300-16304.

Coordinate regulation of stromelysin and collagenase genes determined with cDNA probes.
Frisch SM, Clark EJ, Werb Z.
Proc Natl Acad Sci USA. 1987;84(9):2600-2604.


A chimeric, ligand-binding v-erbB/EGF receptor retains transforming potential.
Riedel H, Schlessinger J, Ullrich A.
Science. 1987;236(4798):197-200.

A chimaeric receptor allows insulin to stimulate tyrosine kinase activity of epidermal growth factor receptor.
Riedel H, Dull TJ, Schlessinger J, Ullrich A.
Nature. 1986;324(6092):68-70.

Protein kinases in cellular signal transduction: tyrosine kinase growth factor receptors and protein kinase C.
Ullrich A, Riedel H, Yarden Y, Coussens L, Gray A, Dull TJ, Schlessinger J, Waterfield MD, Parker PJ.
Cold Spring Harb Symp Quant Biol. 1986;51 Pt 2:713-724.

Blockage of tropoelastin secretion by monensin represses tropoelastin synthesis at a pretranslational level in rat smooth muscle cells.
Frisch SM, Davidson JM, Werb Z.
Mol Cell Biol. 1985;5(1):253-258.


Different membrane anchors allow the Semliki Forest virus spike subunit E2 to reach the cell surface.
Riedel H.
J Virol. 1985;54(1):224-228.


Changes in cell shape correlate with collagenase gene expression in rabbit synovial fibroblasts.
Aggeler J, Frisch SM, Werb Z.
J Cell Biol. 1984;98(5):1662-1671.


Collagenase is a major gene product of induced rabbit synovial fibroblasts.
Aggeler J, Frisch SM, Werb Z.
J Cell Biol. 1984;98(5):1656-1661.


Cell surface expression of fusogenic vesicular stomatitis virus G protein from cloned cDNA.
Riedel H, Kondor-Koch C, Garoff H.
EMBO J. 1984;3(7):1477-1483.


Expression of viral membrane proteins from cloned cDNA by microinjection into eukaryotic cell nuclei.
Timm B, Kondor-Koch C, Lehrach H, Riedel H, Edstrom JE, Garoff H.
Methods Enzymol. 1983;96:496-511.

A procedure to verify an amino acid sequence which has been derived from a nucleotide sequence: application to the 26S RNA of Semliki Forest virus.
Garoff H, Riedel H, Lehrach H.
Nucleic Acids Res. 1982;10(2):675-687.


Structure and assembly of alphaviruses.
Garoff H, Kondor-Koch C, Riedel H.
Curr Top Microbiol Immunol. 1982;99:1-50.

Expression of the structural proteins of Semliki Forest virus from cloned cDNA microinjected into the nucleus of baby hamster kidney cells.
Kondor-Koch C, Riedel H, Soderberg K, Garoff H.
Proc Natl Acad Sci USA. 1982;79(15):4525-4529.


Nucleotide sequence at the junction between the nonstructural and the structural genes of the semliki forest virus genome.
Riedel H, Lehrach H, Garoff H.
J Virol. 1982;42(2):725-729.


Mutator activity of a short Okazaki fragment mutant of Escherichia coli.
Frisch SM, Couch JL, Glaser DA.
J Bacteriol. 1978;134(3):1192-1194.